A5066588161- Weed Control and Herbicide Applications
- Plant tissue culture and regeneration
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Insect Resistance and Genetics
- Biochemical and Molecular Research
- Polyamine Metabolism and Applications
- Enzyme Structure and Function
- Microbial Natural Products and Biosynthesis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- Trypanosoma species research and implications
- Biopolymer Synthesis and Applications
- Synthesis and biological activity
- Soybean genetics and cultivation
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- Malaria Research and Control
- Plant nutrient uptake and metabolism
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- Insect and Pesticide Research
- Adenosine and Purinergic Signaling
La Trobe University
2016-2023
Institute for Molecular Science
2016-2019
Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat agricultural production. Therefore, new herbicides with novel modes of action urgently needed. In this study, we exploited herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis. The class plant DHDPS inhibitors micromolar potency against Arabidopsis thaliana was identified using high-throughput chemical screen. We...
A series of 4-cyano-3-methylisoquinolines have been shown to inhibit parasite cytokinesis and erythrocyte invasion.
Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects herbicide-resistant weeds. We recently developed first herbicidal inhibitors lysine biosynthesis, which provided proof-of-concept for a promising herbicide target. In this study, we expanded upon our understanding mode biosynthesis inhibitors. previously postulated that these may act as proherbicides. Here, show is not case. report an additional inhibitors,...
DHDPS represents a novel enzyme target for the development of new antibiotics to combat multidrug resistance.
The synthesis of the first low micromolar dimeric inhibitor E. coli DHDPS is reported.
Abstract Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat agricultural production. Therefore, new herbicides urgently needed. In this study, we exploited novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis. Using high throughput chemical screen, identified class of plant DHDPS inhibitors that have micromolar potency against Arabidopsis thaliana isoforms. Employing...
The cell wall of Gram‐negative bacteria consists peptidoglycan chains linked together by oligopeptidic sequences comprised the amino acids L ‐Ala, D ‐Glu and meso‐ diaminopimelate (DAP). Meso ‐DAP is synthesized via DAP pathway that also yields basic acid, ‐lysine. Gene knock‐out studies show enzymes functioning in are essential to bacteria, including dihydrodipicolinate synthase (DHDPS). DHDPS an allosteric enzyme catalyzes first‐committed rate‐limiting step biosynthesis. It forms a...
ABSTRACT Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects herbicide-resistant weeds. We recently developed first herbicidal inhibitors lysine biosynthesis, which provided proof-of-concept for a promising herbicide target (Soares da Costa et al., 2021). In this study, we expanded upon our understanding mode biosynthesis inhibitors. previously postulated that these may act as proherbicides Here show is not case....