A5009257480- Medieval Literature and History
- Reformation and Early Modern Christianity
- Middle East and Rwanda Conflicts
- Islamic Studies and History
- Historical and Religious Studies of Rome
- Malaria Research and Control
- Historical and Archaeological Studies
- Socioeconomic Development in MENA
- Mosquito-borne diseases and control
- Early Modern Women Writers
- Historical Studies of British Isles
- Historical Economic and Social Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Trypanosoma species research and implications
- Cancer survivorship and care
- Computational Drug Discovery Methods
- Historical Legal Studies and Society
- Medieval and Early Modern Justice
- Phosphodiesterase function and regulation
- Renaissance and Early Modern Studies
- HIV/AIDS Research and Interventions
- Medieval History and Crusades
- Topic Modeling
- Explainable Artificial Intelligence (XAI)
Birkbeck, University of London
2014-2023
The University of Melbourne
2012-2016
Burnet Institute
2012-2016
Peter Doherty Institute
2016
Yale Cancer Center
2012-2015
Smilow Cancer Hospital
2015
King's College London
2010-2012
Yale University
2012
Katherine Hospital
2012
Harvard University
2012
During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving series of distinct receptor-ligand binding events. Understanding each element in this increases the potential to block parasite's life cycle drugs or vaccines. To investigate specific interactions, they were systematically blocked using combination genetic deletion, enzymatic receptor cleavage and inhibition antibodies, peptides small molecules, resulting...
Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, the causative agents of severe malaria toxoplasmosis, respectively, undergo several critical developmental transitions during their lifecycle. Most important for human pathogenesis is asexual cycle, in which parasites rounds host cell invasion, replication, egress (exit), destroying tissue process. Previous work has identified roles Protein Kinase G (PKG) A (PKA) parasite yet little understood about regulation...
Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These have developed universal mechanism invasion involving formation 'moving junction' provides stable anchoring point through which the parasite invades cells. The composition moving junction, particularly presence protein Apical Membrane Antigen 1 (AMA1), has recently been subject some controversy. In this commentary we review findings led to current model junction complex dissect...
Over the past decade antiretroviral drugs have dramatically improved prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy regimens is that pre-treatment genotypic "tropism tests" determine virus susceptibility maraviroc been developed primarily subtype B strains, which account only 10% of infections worldwide. We therefore...
Central to the pathogenesis of malaria is proliferation Plasmodium falciparum parasites within human erythrocytes. Parasites invade erythrocytes via a coordinated sequence receptor-ligand interactions between parasite and host cell. One key ligand, Apical Membrane Antigen 1 (AMA1), leading blood-stage vaccine previous work indicates that phosphorylation its cytoplasmic domain (CPD) important function during invasion. Here we investigate significance each six available phospho-sites in CPD....
Despite rapid adoption and deployment of large language models (LLMs), the internal computations these remain opaque poorly understood. In this work, we seek to understand how high-level human-interpretable features are represented within neuron activations LLMs. We train $k$-sparse linear classifiers (probes) on predict presence in input; by varying value $k$ study sparsity learned representations varies with model scale. With $k=1$, localize individual neurons which highly relevant for a...
A pilot intervention collecting patient-reported outcomes in two ambulatory clinics led to increased psychosocial distress screening followed by sustained improvement, indicated both process and QOPI measures.
"Women, writing and religion in England beyond, 650–1100." Women's History Review, 30(2), pp. 345–346
A series of 4-cyano-3-methylisoquinolines have been shown to inhibit parasite cytokinesis and erythrocyte invasion.
The ability to determine coreceptor usage of patient-derived human immunodeficiency virus type 1 (HIV-1) strains is clinically important, particularly for the administration CCR5 antagonist maraviroc. envelope glycoprotein (Env) determinants specificity lie primarily within gp120 V3 loop region, although other Env have been shown influence gp120-coreceptor interactions. Here, we determined whether conserved amino acid alterations outside that contribute exist, and these improve performance...
This article explores the significance of weeping in lives late medieval English bishops (c.1100−c.1400). It considers lachrymose devotions saintly alongside tears grief, friendship and self-pity, asks how such displays emotion were understood by contemporary onlookers. is argued that a bishop's key to perceptions his masculinity, sexuality physical body, which turn had significant implications for reputation both as prelate potential saint.
Ruth Mazo Karras, Joel Kaye and E. Ann Matter, Philadelphia, University of Pennsylvania Press, 2008, xviii +328 pp., £39 (hardback), ISBN 9780812240801 This volume brings together a stellar cast of...
Food and drink played an important part in medieval piety, but to date most studies of this topic have focused on the food practices women. This article seeks redress balance by considering significance religious men, through a case study culturally significant well-documented group: saintly bishops England. The these men were shaped thought, also contemporary ideas about body, gender, social status. Ultimately, holy man’s relationship with would influence his chances canonization.