A5081862553- Metal and Thin Film Mechanics
- Advanced materials and composites
- Cytokine Signaling Pathways and Interactions
- Textile materials and evaluations
- Atherosclerosis and Cardiovascular Diseases
- Surface Treatment and Coatings
- Advanced Proteomics Techniques and Applications
- Advancements in Materials Engineering
- Electron and X-Ray Spectroscopy Techniques
- Material Properties and Applications
- Advanced Materials Characterization Techniques
- Immune Response and Inflammation
- Ergonomics and Musculoskeletal Disorders
- Advanced ceramic materials synthesis
- Metal Alloys Wear and Properties
- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Metallic Glasses and Amorphous Alloys
- Intermetallics and Advanced Alloy Properties
- Powder Metallurgy Techniques and Materials
- Aluminum Alloys Composites Properties
- Pigment Synthesis and Properties
- nanoparticles nucleation surface interactions
- Dyeing and Modifying Textile Fibers
- Monoclonal and Polyclonal Antibodies Research
Jagiellonian University
2023
Oslo University Hospital
2016-2021
University of Oslo
2018
Adam Mickiewicz University in Poznań
2010-2014
Warsaw University of Technology
1999-2014
Łukasiewicz Research Network - Textile Research Institute
2011-2014
Faculty (United Kingdom)
2012
Institute of Molecular Biology and Biotechnology
2012
Abstract Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting coordinated response to stimuli. Mass spectrometry-based proteomics combination with fractionation can provide comprehensive maps spatio-temporal regulation protein networks cells, but involves laborious workflows does not cover the phospho-proteome level. Here we present high-throughput workflow based on sequential cell profile global proteome and...
Signal integration between IFNγ and TLRs in immune cells has been associated with the host defense against pathogens injury, a predominant role of STAT1. We hypothesize that STAT1-dependent transcriptional changes vascular involved cross-talk TLR4, reflect pro-atherogenic responses human atherosclerosis. Genome-wide investigation identified set genes were synergistically affected by interactions TLR4 VSMCs. These included chemokines Cxcl9, Ccl12, Ccl8, Ccrl2, Cxcl10 Ccl5, adhesion molecules...
Inflammation plays an important role in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of atherosclerosis. Signal transducer activated transcription 1 (STAT1) has been identified as a point convergence for cross talk between pro-inflammatory cytokine interferon γ (IFNγ) Toll-like receptor-4 (TLR4) ligand LPS immune cells. However, there is no information available on STAT1 TLR4-mediated progression atherosclerosis potential synergism...
The melting of aluminum thin film was studied by a molecular dynamics (MD) simulation technique. effect the grain size and type confinement investigated for with constant thickness 4 nm. results show that coherent intercrystalline interface suppress transition solid into liquid, while free-surface gives point depression. mechanism polycrystalline investigated. It found starts at boundaries propagates to interiors. calculated from Lindemann index criterion, taking account only atoms near...
Atherosclerotic plaque development involves multiple extra- and intra-cellular signals engaging cells from the immune system vasculature. Pro-inflammatory pathways activated by interferon gamma (IFNγ) toll-like receptor 4 (TLR4) ligands are profoundly involved in formation have been shown to involve cross-talk all atheroma-interacting cell types leading increased activation of signal transducer activator transcription-1 (STAT1) elevated expression pro-inflammatory mediators. Here we...
The prevalence of cardiovascular disease in patients with renal failure is extremely high and accounts for a large part the morbidity mortality. Inflammation participates importantly host defense against infectious agents injury, but also contributes to pathophysiology many diseases, including atherosclerosis, which main problem failure. Recruitment blood leukocytes injured vascular endothelium characterizes initiation progression atherosclerosis involves inflammatory mediators, modulated by...
This paper deals with a three-dimensional analogue to the method of bisections for solving nonlinear system equations $F(X) = \theta {(0,0,0)^T}$, which does not require evaluation derivatives F. We divide original parallelepiped (Figure 2.1) into 8 tetrahedra 2.2), and then bisect form an infinite sequence tetrahedra, whose vertices converge $Z \in {R^3}$ such that $F(Z) \theta$. The process bisecting tetrahedron $< | > {E_1}{E_2}{E_3}{E_4}$ ${E_i}$ is defined as follows. first locate...