A5002351608- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Chemical synthesis and alkaloids
- Metabolomics and Mass Spectrometry Studies
- Genetics, Bioinformatics, and Biomedical Research
- Crystallography and molecular interactions
- Marine Sponges and Natural Products
- Analytical Chemistry and Chromatography
- Plant Pathogens and Fungal Diseases
- X-ray Diffraction in Crystallography
- Molecular spectroscopy and chirality
- Beetle Biology and Toxicology Studies
- Cancer therapeutics and mechanisms
- Traditional and Medicinal Uses of Annonaceae
- Enzyme function and inhibition
- Alkaloids: synthesis and pharmacology
- Crystallization and Solubility Studies
- Cancer Treatment and Pharmacology
University of Illinois Chicago
2022-2024
University of North Carolina at Greensboro
2019-2021
Two separate commercial products of kratom [Mitragyna speciosa (Korth.) Havil. Rubiaceae] were used to generate reference standards its indole and oxindole alkaloids. While has been studied for over a century, the characterization data in literature many alkaloids are either incomplete or inconsistent with modern standards. As such, full 1H 13C NMR spectra, along HRESIMS ECD data, reported 1–19. Of these, four new (7, 11, 17, 18) characterized using 2D absolute configurations 7, 18...
Current treatment options for bacterial infections are dependent on antibiotics that inhibit microbial growth and viability. These approaches result in the evolution of drug-resistant strains bacteria. An anti-infective strategy is less likely to lead development resistance disruption quorum sensing mechanisms, which involved promoting virulence. The goal this study was identify fungal metabolites effective as inhibitors. Three new prenylated diresorcinols (1-3), along with two known...
Four new bislactones, dihydroacremonol (1), clonostachyone (2), acremodiol B (3), and C (4), along with one known compound, hymeglusin (5), were isolated from cultures of two fungal strains (MSX59876 MSX59260). Both identified based on phylogenetic analysis molecular data as Clonostachys spp.; yet, they biosynthesized a suite related, but different, secondary metabolites. Given the challenges associated elucidating structures configurations GIAO NMR calculations tested complement to...
We established a university-community partnership with the Boys and Girls Clubs of Chicago (BGCC)-named
For over a century, researchers have cultured microorganisms together on solid support─typically agar─in order to observe growth inhibition via antibiotic production. These simple bioassays been critical both academic that study production in and the pharmaceutical industry's global effort discover drugs. Despite utility of agar assays around globe, several limitations prevented their widespread adoption advanced high-throughput compound discovery dereplication campaigns. To address list...
Since the Golden Age of natural product (NP) antibiotic discovery in mid-1950s, NP has declined despite methodological advances. As a result, antibacterial is being outpaced by resistance. One significant challenge rediscovery compounds previously isolated from bacteria. Generating diverse microbial library can help overcome compounds, but major challenges to this approach include inefficiency commonly used methods create high-throughput libraries bacteria and difficulty reducing redundancy...