A5102780579- Wound Healing and Treatments
- Hepatitis C virus research
- DNA and Nucleic Acid Chemistry
- HIV/AIDS drug development and treatment
- Acne and Rosacea Treatments and Effects
- Infant Nutrition and Health
- Infective Endocarditis Diagnosis and Management
- Burn Injury Management and Outcomes
- Pneumonia and Respiratory Infections
- Advanced biosensing and bioanalysis techniques
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Bacterial Infections and Vaccines
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Mycotoxins in Agriculture and Food
- Plant Disease Resistance and Genetics
- Bacterial biofilms and quorum sensing
- Neonatal and Maternal Infections
- Diagnosis and Treatment of Venous Diseases
- Streptococcal Infections and Treatments
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
- Pressure Ulcer Prevention and Management
- Hepatitis B Virus Studies
University of North Carolina at Greensboro
2020-2024
Mexican Social Security Institute
2019
Research Triangle Park Foundation
2013-2015
GlaxoSmithKline (United States)
2013-2015
Mayo Clinic
2015
Inserm
2011
The University of Adelaide
2011
University of Bern
1999-2000
SA Health
1998
Advanced Tissue (United States)
1998
is a major human pathogen. In contrast,
The topical use of antiseptics for wound care has a role in an antimicrobial stewardship strategy. However, the details this need clarification. Further clinical research into would lower risk furthering antibiotic resistance and contribute to more effective use. As part research, experimental surveillance data are needed on tolerance patterns associated with antiseptic infections.
S ummary . A method for sampling quantitatively bacteria present in the subsurface pilo‐sebaceous units of human skin is described. Less than 0.5% a marker surface organism was isolated and counts up to 10 6 organisms/cm 2 obtained.
A boronic acid moiety was found to be a critical pharmacophore for enhanced in vitro potency against wild-type hepatitis C replicons and known clinical polymorphic resistant HCV mutant replicons. The synthesis, optimization, structure-activity relationships associated with inhibition of replication subgenomic system series non-nucleoside boron-containing RNA-dependent RNA polymerase (NS5B) inhibitors are described. summary the discovery 3 (GSK5852), molecule which entered trials subjects...
We describe the preclinical development and in vivo efficacy of a novel chemical series that inhibits hepatitis C virus replication via direct interaction with viral nonstructural protein 4B (NS4B). Significant potency improvements were realized through isosteric modifications to our initial lead 1a. The temptation improve antiviral activity while compromising physicochemical properties was tempered by judicial use ligand efficiency indices during optimization. In this manner, compound 1a...
A satisfactory clinical response to long-term oral tetracycline treatment was associated with a mean serum of 1.98 mug/ml. The surface lipid showed an increased triglyceride, decreased free fatty acids, and cholesterol, the amount keratin within pilosebaceous duct reduced. At this dose level there no quantitative decrease in bacterial flora though acids. We believe that latter due direct inhibition by on extracellular lipases.
Rapid clinical progress of hepatitis C virus (HCV) replication inhibitors, including these selecting for resistance in the NS5A region (NS5A inhibitors), promises to revolutionize HCV treatment. Herein, we describe our explorations diverse spiropyrrolidine motifs novel inhibitors and a proposed interaction model. We discovered that 1,4-dioxa-7-azaspiro[4.4]nonane motif inhibitor 41H (GSK2236805) supported high potency against genotypes 1a 1b as well genotype L31V Y93H mutants. Consistent...
Although lead optimization (LO) is by definition a process, process-centric analysis and visualization of this important phase pharmaceutical R&D has been lacking. Here we describe simple statistical framework to quantify visualize the progression LO projects so that vital signs convergence can be monitored. We refer resulting visualizations generated our methodology as "LO telemetry" project. These automated provide objective, holistic, instantaneous communication progression. This enhances...
A new series of short pyrrole tetraamides are described whose submicromolar DNA binding affinity is an essential component for their strong antibacterial activity. This class compounds related to the linked bis-netropsins and bis-distamycins, but here, only one amino-pyrrole-carboxamide unit amidine tail connected either side a central dicarboxylic acid linker. The highest degree binding, measured by compound-induced changes in UV melting temperatures AT-rich oligomer, was observed flat,...
The bacteriological quality of pooled human milk donated to the Oxford bank was analysed and effects on bacteriology sterilisation milk-collecting vessels in home with hypochlorite solution Holder pasteurisation a purpose-built human-milk pasteuriser were studied. Collecting hypochlorite-sterilised resulted significantly lower bacterial count both pathogens species unlikely pathogenicity before increased chance giving sterile product. Potentially pathogenic organisms grown untreated...
Cryptic fungal pathogens pose significant identification and disease management challenges due to their morphological resemblance known pathogenic species while harboring genetic (often) infectionrelevant trait differences. The cryptic pathogen
A quantitative study was made of the microflora 174 acne and 68 non-acne subjects. Two groups organisms were investigated, anaerobic diphtheroids members Micrococcaceae. The results showed high numbers both bacteria in skin bearing blackheads, papules or pustules adolescent skin. There significantly lower pilosebaceous ducts normal looking areas pre-adolescent when compared with It is suggested that increased alone do not predispose to acne, but their interaction skin, which a function...
To assess the bacteriological quality of unpooled expressed breast milk, a pilot bottle sample each donation was examined before milk given to neonate. Provided did not contain greater than 2500 organisms/ml or potential pathogens it used unheated. Milk containing between and 5000 no after pasteurisation. Using these criteria, 67% 460 donations were acceptable. However, because varied, 45% domiciliary discarded compared with only 29% those from hospital.
Antimicrobial resistance is an ever-increasing global concern, with the era of untreatable infection becoming a reality. Wound care no exception, increasing issues antibiotic-resistant infections across different wound types and settings. Antibiotic stewardship have been priority for most strategic interventions so far; however, in care, alternative or supplementary strategies using antiseptics should be considered. Antiseptics such as silver can provide effective cidal activity broad range...
Infections in burn patients are still the principal cause of complications injuries. The aim this study is to assess a new strategy for wound management view infection prevention and treatment experience Burn Treatment Center Siemianowice Śląskie. applied methodology involved analysis patient records describing hospital's epidemiological situation between 2014 2016. also included use cost antibiotics, silver‐containing dressings, other antiseptics relative number sepsis cases, including...
Vive la différence! Replacement of the base-linker amide functionality in peptide nucleic acids (PNAs) by an isostructural C−C double bond (shown schematically) leads to a dramatic change DNA affinity, preferred strand orientation, and triplex-forming properties, thus highlights importance electrostatic properties over geometric PNA/DNA recognition.
Four new bislactones, dihydroacremonol (1), clonostachyone (2), acremodiol B (3), and C (4), along with one known compound, hymeglusin (5), were isolated from cultures of two fungal strains (MSX59876 MSX59260). Both identified based on phylogenetic analysis molecular data as Clonostachys spp.; yet, they biosynthesized a suite related, but different, secondary metabolites. Given the challenges associated elucidating structures configurations GIAO NMR calculations tested complement to...