A5063561179- Spaceflight effects on biology
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Neural dynamics and brain function
- Health, Environment, Cognitive Aging
- Biomedical and Engineering Education
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Genetics, Bioinformatics, and Biomedical Research
- Photosynthetic Processes and Mechanisms
- Advanced Chemical Physics Studies
- Space Science and Extraterrestrial Life
- CRISPR and Genetic Engineering
- High Altitude and Hypoxia
- Planetary Science and Exploration
- Cell Image Analysis Techniques
- Birth, Development, and Health
- Scientific Computing and Data Management
- Light effects on plants
- Genomics and Chromatin Dynamics
- Astrophysics and Star Formation Studies
- Complex Systems and Time Series Analysis
- Molecular Spectroscopy and Structure
- Circadian rhythm and melatonin
University of Tsukuba
2019-2024
University of Glasgow
2024
Iowa State University
2019-2020
National Institute of Mental Health
2009
Search for Extraterrestrial Intelligence
2008
Pennsylvania State University
2008
Ames Research Center
2008
Abstract Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types human body. Here, we propose that a parallel Space could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit permit advent of precision spaceflight healthcare. Alongside scientific potential, consider...
Abstract Objective: The “default network” represents a baseline condition of brain function and is interest in schizophrenia research because its component regions are believed to be aberrant the disorder. We hypothesized that magnetoencephalographic (MEG) source localization analysis would reveal abnormal resting activity within particular frequency bands schizophrenia. Experimental Design: Eyes‐closed state MEG signals were collected for two comparison groups. Patients with ( N = 38)...
The near-infrared (NIR) spectra and absolute band strengths of 10 nitrogenated polycyclic aromatic hydrocarbon (PANH) radical cations isolated in an argon matrix are presented compared with the their parent (PAH) cations. 0.7-2.5 μm (14,500-4000 cm−1) spectrum for open-shell cation forms two anthracenes (C13H9N C12H8N2), four isomeric benzanthracenes (C17H11N), dibenzanthracenes (C21H13N) reported. These ionized PANHs have allowed electronic transitions that give rise to strong absorption...
Complex networks have been observed to comprise small-world properties, believed represent an optimal organization of local specialization and global integration information processing at reduced wiring cost. Here, we applied magnitude squared coherence resting magnetoencephalographic time series in reconstructed source space, acquired from controls patients with schizophrenia, generated frequency-dependent adjacency matrices modeling functional connectivity between virtual channels. After...
Rodent models have been widely used as analogs for estimating spaceflight-relevant molecular mechanisms in human tissues. NASA GeneLab provides access to numerous spaceflight omics datasets that can potentially generate novel insights and hypotheses about fundamental space biology when analyzed new integrated fashions. Here, we performed a pilot study elucidate biological across tissues by reanalyzing mouse RNA-sequencing data archived on GeneLab. Our results showed clock gene expressions...
Parts of Europe and the United States have witnessed dramatic losses in commercially managed honey bees over past decade to what is considered an unsustainable extent. The large-scale loss has considerable implications for agricultural economy because are one leading pollinators numerous crops. Bee declines been associated with several interactive factors. Recent studies suggest nutritional pathogen stress can interactively contribute bee physiological declines, but molecular mechanisms...
Despite the availability of many ready-made testing software, reliable detection differentially expressed genes in RNA-seq data is not a trivial task. Even though collection considered high-throughput, analysis has intricacies that require careful human attention. Researchers should use modern techniques incorporate visual feedback to verify appropriateness their models. While some packages provide static visualization tools, capabilities be expanded and meaningfulness explicitly...
The search for life beyond the Earth is overarching goal of NASA Astrobiology Program, and it underpins science missions that explore environments Solar System planets exoplanets. However, detection extraterrestrial life, in our beyond, sufficiently challenging likely multiple measurements approaches, spanning disciplines missions, will be needed to make a convincing claim. Life therefore not an instantaneous process, unlikely unambiguous-yet high-stakes scientific achievement garner...
Iron deficiency chlorosis (IDC) is a global crop production problem, significantly impacting yield. However, most IDC studies have focused on model species, not agronomically important crops. Soybean the second largest grown in United States, yet calcareous soils across of upper U.S. Midwest limit soybean growth and profitability. To understand early iron stress responses, we conducted whole genome expression analyses (RNA-sequencing) leaf root tissue from efficient (Glycine max) cultivar...
A wealth of viral data sits untapped in publicly available metagenomic sets when it might be extracted to create a usable index for the virological research community. We hypothesized that work this complexity and scale could done hackathon setting. Ten teams comprised over 40 participants from six countries, assembled crowd-sourced set analysis processing pipelines complex biological three-day event on San Diego State University campus starting 9 January 2019. Prior hackathon, 141,676...
Interactive data visualization is imperative in the biological sciences. The development of independent layers interactivity has been pursuit community. We developed bigPint, a package available on Bioconductor under GPL-3 license (https://bioconductor.org/packages/release/bioc/html/bigPint.html). Our software introduces new technology that enables using Plotly R, which aids exploration large datasets. bigPint presents modernized versions scatterplot matrices, volcano plots, and litre plots...
This paper introduces ggenealogy (Rutter, Vanderplas, and Cook 2019), a developing R software package that provides tools for searching through genealogical data, generating basic statistics on their graphical structures using parent child connections, parsing performing calculations branches of interest, displaying the results. It is possible to draw genealogy in relation variables related nodes, determine display shortest path distances between nodes. Production pairwise distance matrices...