A5011851390- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Reproductive Physiology in Livestock
- Adipose Tissue and Metabolism
- Veterinary Equine Medical Research
- Growth Hormone and Insulin-like Growth Factors
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Regulation of Appetite and Obesity
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Renal and related cancers
- Fatty Acid Research and Health
- Veterinary Medicine and Surgery
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
University of Cambridge
2015-2025
Oxford Brookes University
2015-2025
University of Southampton
2011
University of Liverpool
1994-1997
Queen's Medical Centre
1995
In rats, maternal anaemia during pregnancy causes hypertension in the adult offspring, although mechanism is unknown. The present study investigated renal morphology of rats born to mothers who were Fe-deficient pregnancy. Rats fed either a control (153 mg Fe/kg diet, n 7) or low-Fe (3 mg/kg 6) diet from 1 week before mating and throughout gestation. At delivery, Fe-restricted (IR) anaemic; IR pups also anaemic growth-retarded at 2 d age. 3 16 months, systolic blood pressure offspring (163...
Abstract Using indwelling crown–rump length (CRL)-measuring devices, the growth rate of sheep fetuses was monitored during late gestation and after experimental manipulation fetal plasma cortisol by exogenous infusion adrenalectomy. In intact control fetuses, increment in CRL declined progressively last 20–25 days gestation: mean ± s.e.m. values fell from 5·5 0·4 mm/day ( n =12) at 21–25 before delivery to 2·5 0·3 5 birth P <0·01). These changes closely parallelled normal prepartum...
In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods early development can alter adult phenotype. Hormones an important role in these epigenetic modifications signal the type, severity duration cue to developing feto‐placental tissues. They affect tissues both directly indirectly by changes placental act gene expression, hence protein abundance wide different tissues, which has functional...
The inflammasome is a multiprotein complex whose formation triggered when NOD-like receptor binds pathogen ligand, resulting in activated caspase-1, which converts certain interleukins (IL-1β, IL-18, and IL-33) to their active forms. There currently no information on regulation of this system around the time birth. We employed transcript profiling fetal rat intestinal lung RNA at embryonic days 16 (E16) 20 (E20) with out-of-sample validation using quantitative RT-PCR. Transcript RT-PCR...
Delivery of viable young requires co-ordination fetal maturation with the onset labour at term. In turn, this depends on a cascade and maternal endocrine events. The sequence these events is broadly similar in most mammals but there are differences placental hormone synthesis timing magnitude key prepartum changes between species. farm animals, progesterone (P4) levels decline oestrogen increase last 5–10 days before delivery response to activation hypothalamic-pituitary-adrenal (HPA) axis...
We have reported that blood pressure was elevated in 3-month-old rats whose mothers were Fe-restricted during pregnancy. These animals also had improved glucose tolerance and decreased serum triacylglycerol. The aim of the present study to determine whether these effects maternal nutritional restriction, at 3 months age, can be observed same later life. Pulmonary angiotensin converting enzyme (ACE) concentrations measured investigate renin–angiotensin system involved elevation offspring...
Preterm infants have low serum T4 and T3 levels, which may partly explain the immaturity of their tissues. Deiodinase enzymes are important in determining bioavailability thyroid hormones: deiodinases D1 D2 convert to T3, whereas deiodinase D3 inactivates produces rT3 from T4. In human ovine fetuses, plasma rises near term association with prepartum cortisol surge. This study investigated developmental effects on tissue hormones fetal sheep during late gestation. Plasma concentrations utero...
In developed countries, the increasing incidence of obesity is a serious health problem. Leptin exposure in perinatal period affects long-term regulation appetite and energy expenditure, but control leptin production utero unclear. This study investigated perirenal adipose tissue (PAT) placental expression ovine fetuses during late gestation after manipulation plasma glucocorticoid thyroid hormone concentrations. Between 130 144 d (term at 145 +/- 2 d), PAT mRNA levels increased association...
Key points Skeletal muscle energy requirements increase at birth but little is known regarding the development of mitochondria that provide most cellular as ATP. Thyroid hormones are regulators adult metabolism and important in driving several aspects fetal development, including fibre differentiation. Mitochondrial density abundance mitochondrial membrane proteins skeletal increased during late gestation. However, functional capacity, measured oxygen consumption rate, primarily after birth....