A5083345783- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Global Maternal and Child Health
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Grief, Bereavement, and Mental Health
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Cardiovascular Conditions and Treatments
- Epigenetics and DNA Methylation
- Congenital Heart Disease Studies
- Autopsy Techniques and Outcomes
- Estrogen and related hormone effects
- Infant Development and Preterm Care
- Cardiac Arrhythmias and Treatments
- Health disparities and outcomes
- Neuroscience of respiration and sleep
- Inflammatory mediators and NSAID effects
University of Cambridge
2016-2025
Rosie Hospital
2012-2024
Bridge University
2001-2024
National Institute for Health Research
2013-2023
NIHR Cambridge Biomedical Research Centre
2014-2023
NHS Greater Glasgow and Clyde
2004-2023
National University of Singapore
2023
Health and Human Development (2HD) Research Network
2023
Virginia Commonwealth University
2022
Transnational Press London
2021
The risk of adverse perinatal outcome among 8839 women recruited to a multicenter, prospective cohort study was related maternal circulating concentrations trophoblast-derived proteins at 8-14 wk gestation. Women with pregnancy-associated plasma protein A (PAPP-A) in the lowest fifth percentile gestation had an increased intrauterine growth restriction [adjusted odds ratio, 2.9; 95% confidence interval (CI), 2.0-4.1], extremely premature delivery (adjusted CI, 1.6-5.5), moderately 2.4;...
Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN). The aim our study was to examine the SEN across full range gestation.We conducted a population-based, retrospective by linking school census data on 407,503 eligible school-aged children resident in 19 Scottish Local Authority areas (total population 3.8 million) their routine birth data. recorded 17,784 (4.9%) children; 1,565 (8.4%) those born 16,219 (4.7%) at...
The C statistic is a commonly reported measure of screening test performance. Optimistic estimation the frequent problem because overfitting statistical models in small data sets, and methods exist to correct for this issue. However, many studies do not use such methods, those that optimism diverse some which are known be biased. We used clinical sets (United Kingdom Down syndrome from Glasgow (1991–2003), Edinburgh (1999–2003), Cambridge (1990–2006), as well Scottish national pregnancy...
Policy decisions often require synthesis of evidence from multiple sources, and the source studies typically vary in rigour relevance to target question. We present simple methods allowing for differences (or lack internal bias) external synthesis. The are developed context reanalysing a UK National Institute Clinical Excellence technology appraisal antenatal care, which includes eight comparative studies. Many were historically controlled, only one was randomized trial doses, populations...
This study examined the cardiac structure and function of a unique cohort documented lifelong, competitive endurance veteran athletes (>50 yr). Twelve lifelong male [mean ± SD (range) age: 56 6 yr (50–67)], 20 age-matched controls [60 5 yr; (52–69)], 17 younger [31 (26–40)] without significant comorbidities underwent magnetic resonance (CMR) imaging to assess morphology function, as well CMR with late gadolinium enhancement (LGE) myocardial fibrosis. Lifelong had smaller left (LV) right...
The risk of antepartum stillbirth at term is higher among women 35 years age or older than younger women. Labor induction may reduce the stillbirth, but it also increase cesarean delivery, which already common in this group.We conducted a randomized, controlled trial involving primigravid who were older. Women randomly assigned to labor between 39 weeks 0 days and 6 gestation expectant management (i.e., waiting until spontaneous onset development medical problem that mandated induction)....
OBJECTIVE To determine whether fetal overgrowth precedes the diagnosis of gestational diabetes mellitus (GDM) and to quantify interrelationships among overgrowth, GDM, maternal obesity. RESEARCH DESIGN AND METHODS We conducted a prospective cohort study unselected nulliparous women performed ultrasonic measurement abdominal circumference (AC) head (HC) at 20 28 weeks age (wkGA). Exposures were GDM ≥28 wkGA The risk AC >90th HC-to-AC ratio <10th percentile was modeled using...
The placenta is the interface between mother and fetus inadequate function contributes to short long-term ill-health. absent from most large-scale RNA-Seq datasets. We therefore analyze long small RNAs (~101 20 million reads per sample respectively) 302 human placentas, including 94 cases of preeclampsia (PE) 56 fetal growth restriction (FGR). placental transcriptome has seventh lowest complexity 50 tissues: 271 genes account for 50% all reads. identify multiple circular validate 6 these by...
GDF15, a hormone acting on the brainstem, has been implicated in nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but full mechanistic understanding is lacking
ContextTrial of labor after previous cesarean delivery is associated with increased risk uterine rupture. However, no reliable data exist on the effect a trial perinatal death in otherwise uncomplicated term pregnancies.ObjectiveTo determine intrapartum stillbirth or neonatal not related to congenital abnormality among women pregnancies who had delivery, compared having planned repeat and multiparous nulliparous at delivered by method.Design SettingPopulation-based, retrospective cohort...
To determine whether a short interval between pregnancies is an independent risk factor for adverse obstetric outcome.Retrospective cohort study.Scotland.89 143 women having second births in 1992-8 who conceived within five years of their first birth.Intrauterine growth restriction (birth weight less than the 5th centile gestational age), extremely preterm birth (24-32 weeks), moderately (33-36 and perinatal death.Women whose subsequent interpregnancy was six months were more likely other to...
Previous studies have demonstrated a correlation between first-trimester size and birth weight. It is not known, however, whether low weight related to growth. We sought determine the risk of that was for gestational age embryo or fetus in first trimester.