A5036101289- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Child Nutrition and Water Access
- Blood donation and transfusion practices
- Erythrocyte Function and Pathophysiology
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Erythropoietin and Anemia Treatment
- Trace Elements in Health
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Food Security and Health in Diverse Populations
- Pharmacological Effects and Toxicity Studies
- Malaria Research and Control
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Heme Oxygenase-1 and Carbon Monoxide
- Folate and B Vitamins Research
- Prenatal Screening and Diagnostics
- Religion, Spirituality, and Psychology
- Artificial Intelligence in Healthcare
- Poisoning and overdose treatments
Colombo North Teaching Hospital
2012-2025
University of Kelaniya
2016-2025
General Sir John Kotelawala Defence University
2022
National Hospital of Sri Lanka
2005-2009
John Radcliffe Hospital
2000-2005
University Health Network
2005
Lady Ridgeway Hospital for Children
2005
MRC Weatherall Institute of Molecular Medicine
2003
Vavuniya General Hospital
2001-2003
University of Oxford
2003
GDF15, a hormone acting on the brainstem, has been implicated in nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but full mechanistic understanding is lacking
An improved understanding of the regulation fetal hemoglobin genes holds promise for development targeted therapeutic approaches induction in β-hemoglobinopathies. Although recent studies have uncovered trans-acting factors necessary this regulation, limited insight has been gained into cis-regulatory elements involved.
To assess the efficacy and safety of low dose adrenaline injected subcutaneously to prevent acute adverse reactions polyspecific antivenom serum in patients admitted hospital after snake bite.Prospective, double blind, randomised, placebo controlled trial.District general Sri Lanka.105 with signs envenomation bite, randomised receive either (cases) or (controls) immediately before infusion serum.Adrenaline 0.25 ml (1:1000).Development side effects attributable adrenaline.56 received 49 as...
Introduction Despite the improvement in medical management, many patients with transfusion-dependent β-thalassaemia die prematurely due to transfusion-related iron overload. As per current guidelines, optimal chelation of cannot be achieved patients, even two chelators at their maximum therapeutic doses. Here, we evaluate efficacy and safety triple combination treatment deferoxamine, deferasirox deferiprone over dual deferoxamine on very high Methods analysis This is a single-centre,...
Abstract Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness β-thalassaemia unproven. We conducted a randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of hydroxyurea transfusion-dependent β-thalassaemia. Sixty patients were assigned 1:1 oral 10–20 mg/kg/day or placebo for 6 months by stratified block randomisation. treatment did not alter blood transfusion volume overall....
Objectives Thalassaemia is a genetic disorder of haemoglobin synthesis characterised by life-long chronic anaemia. Although the endocrine and cardiac complications thalassaemia are well-studied, hepatic renal understudied. This study aims to describe functions understand their determinants among paediatric patients with β-thalassaemia. Design Cross-sectional study. Setting Two largest centres in Sri Lanka. Participants All haematologically confirmed β-thalassaemia aged 1–16 years attending...
Objectives Ineffective erythropoiesis, although at a mild degree, could make individuals with beta thalassaemia trait (BTT) vulnerable to folate deficiency. This be more pronounced in communities where dietary intake of is substantially lower. We aimed assess serum levels and consumption BTT compare them healthy matched controls. Design A case–control study. Setting study was conducted between June 2021 2022 regional centre Sri Lanka. Participants The includes 100 sets samples, including an...
Summary. The β‐globin gene mutations and the α‐globin genes of 620 patients with phenotype severe to moderate thalassaemia from seven centres in Sri Lanka were analysed. Twenty‐four identified, three accounting for 84·5% 1240 alleles studied: IVSI‐5 (G→C) 56·2%; IVSI‐1 (G→A) 15·2%; haemoglobin E (codon (CD)26 GAG→GAA) 13·1%. Three new found; a 13‐bp deletion removing last nucleotide CD6 CD10 inclusively, IVSI‐129 (A→C) consensus splice site, frame shift, CD55 (–A). allele frequency α + was...
Severe forms of anemia in children the developing countries may be characterized by different clinical manifestations at particular stages development. Whether this reflects developmental changes adaptation to or other mechanisms is not clear. The pattern has been assessed 110 individuals with hemoglobin (Hb) E beta-thalassemia, one commonest inherited Asia. It found that age and Hb levels are independent variables respect erythropoietin response there a decline latter similar degree during...
In many Asian populations, the commonest form of severe thalassemia results from coinheritance HbE and beta thalassemia. The management this disease is particularly difficult because its extreme clinical diversity; although some genetic adaptive factors have been identified as phenotypic modifiers, reasons remain unclear. Because role environment in course has neglected completely malaria due to both Plasmodium falciparum vivax prevalent Sri Lanka, we carried out a pilot study patients with...
Thalassaemia is a chronic disease without an effective cure in majority. The clinical management has improved considerably during recent years; however, minimal attempts are made to up lift the quality of life among patients, especially developing countries. Here we aim describe and compare determine factors associated with health related patients transfusion dependent β-thalassaemia major haemoglobin E β-thalassemia Sri Lanka. A case control study was conducted three largest thalassaemia...
Summary Studies of the frequency heterozygous carriers for common inherited diseases haemoglobin in over 7500 adolescent children 25 districts Sri Lanka have disclosed a highly significant variation very short geographical distances. A further analysis these findings, including their relationship to past and distribution malaria, climatic variation, altitude, ethnic origin consanguinity rates, provided evidence regarding evolutionary basis variable conditions It is likely that complex...
Human pregnancy is frequently accompanied by nausea and vomiting that may become severe life-threatening, as in hyperemesis gravidarum (HG), the cause of which unknown. Growth Differentiation Factor-15 (GDF15), a hormone known to act on hindbrain emesis, highly expressed placenta its levels maternal blood rise rapidly pregnancy. Variants
Abstract Anemia affects over 800 million women and children globally. Measurement of hepcidin as an index iron status shows promise, but its diagnostic performance where hemoglobinopathies are prevalent is unclear. We evaluated the a test deficiency in adolescents across Sri Lanka. selected 2273 samples from nationally representative cross‐sectional study 7526 secondary schoolchildren Lanka analyzed associations between participant characteristics, indices, inflammatory markers,...