A5075020744- Hepatitis B Virus Studies
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- Malaria Research and Control
- Parasitic Diseases Research and Treatment
- Biotechnology and Related Fields
- Tuberculosis Research and Epidemiology
- Blood groups and transfusion
- Research on Leishmaniasis Studies
- Genetics, Bioinformatics, and Biomedical Research
- Insects and Parasite Interactions
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Genomics and Rare Diseases
- Cytomegalovirus and herpesvirus research
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Parasitic Infections and Diagnostics
- Dengue and Mosquito Control Research
- Global Health Workforce Issues
- Insect symbiosis and bacterial influences
University of Kelaniya
2011-2025
Abstract Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness β-thalassaemia unproven. We conducted a randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of hydroxyurea transfusion-dependent β-thalassaemia. Sixty patients were assigned 1:1 oral 10–20 mg/kg/day or placebo for 6 months by stratified block randomisation. treatment did not alter blood transfusion volume overall....
Toxoplasmosis, caused by the parasite Toxoplasma gondii, affects approximately 30% of human population worldwide. Reactivation latent infection in immunocompromised people leads to fatal disease. This study aimed determine seropositivity toxoplasmosis enzyme-linked immunosorbent assay (ELISA), confirmed primary polymerase chain reaction (PCR) and nested PCR (nPCR), validate ELISA against nPCR among a group cancer patients. Of 321 participants, six (1.9%) patients were positive for both IgG...
Background and aims. There is evidence for low-grade inflammation in the pathophysiology of post-infectious irritable bowel syndrome (IBS). We assessed degree subclinical intestinal mucosal diarrhea-predominant IBS (IBS-D) a tropical setting. Material methods. In prospective study over 1 year, we investigated 49 patients with IBS-D (cases; median age 34 years (range 18–59); M:F 36:13), diagnosed on Rome III criteria. 14 individuals family history colon cancer (median 46.5 23–56); 6:8) were...
Leishmaniasis is a disease caused by vector-borne protozoans. In Sri Lanka, the cutaneous form of predominant, which usually diagnosed using Giemsa-stained slit skin smear examination and histology. However, sensitivity smears histology are reportedly low. Moreover, facilities for highly sensitive polymerase chain reaction (PCR) available only in few highly-equipped parasitology laboratories. Therefore, there need low cost, specific screening tests diagnosis leishmaniasis at point need. this...
Keywords: Anticipatory ethics, Data-Enabled Life Sciences Alliance, DELSA, genomics without borders, global ethics and international development in pharmacogenomics, Human Variome Project, RaDiCAL, Rare Disease Consortium for Autosomal Loci
Keywords: Asia-Pacific, genomics and international development, global health, health 2020 policy, knowledge co-production, LMICs, public genomics, science society, theragnostics, cultural lags
Classical hantavirus infections present as haemorrhagic fever with renal syndrome (HFRS) in Euro-Asia and pulmonary (HPS) America. Mixed clinical features have been reported from certain novel infections. In the north-central part of Sri Lanka, clusters patients non-cardiogenic edema recent years. To detect infection among clinically suspected to describe demographic Lanka. Clinically HFRS HPS like illness admitted two leading hospitals country December 2013 November 2015 March 2016 February...
Keywords: Developing countries, developing world genomics, essential medicines, genomics and international development, global personalized medicine, pharmacogenomics primary care, care public health
Leptospirosis is the most widespread zoonosis in world. The disease more prevalent tropical regions where majority of developing countries are located. considered a protean manifestation with severity ranging from mild febrile illness to severe and life-threatening illness. Clinical symptoms leptospirosis overlap other illnesses. Early, rapid, definitive diagnosis important for effective patient management. Since Polymerase Chain Reaction (PCR)-based assays not readily available clinical...
Introduction Despite being one of the first diseases to be genetically characterised, β-thalassaemia remains a disorder without cure in majority patients. Most patients with receive only supportive treatment and therefore have poor quality life shorter spans. Hydroxyurea, which has shown induce fetal haemoglobin synthesis human erythroid cells, is currently recommended for sickle cell disease. However, its clinical usefulness transfusion-dependent unclear. Here, we present protocol...
Though case reports and limited series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has made hitherto to undertake a comprehensive genotypic-phenotypic analysis this "rare" group patients.
Objectives This preliminary study was carried out to determine the allele frequencies and forensic efficiency parameters for short tandem repeat loci CSF1PO, TPOX, THO1, D16S539, D7S820, D13S317, vWA, FESFPS F13B in a test sample population of Sri Lankans. Design Test samples were obtained from 305 nonrelated individuals originating all 9 provinces Lanka. DNA extracted whole blood using chelex- 100 amplified by PCR GenePrint STR kit silver stained. Final profiles analysed paternity indices...
In this paper, we advance the extant health technology innovation frames on global personalized medicine by highlighting need to rethink genomics in real-life settings – including situations where populations are frequently faced with natural disasters or man-made conflicts. We identify steps towards building sufficient capacity effectively harness and integrate genomic molecular diagnostics order benefit society those resource-limited post-war contexts. Surprisingly, despite a great number...
Introduction Hepatitis B infection causes a spectrum of clinical diseases varying from asymptomatic to severe or fulminant acute hepatitis, chronic liver disease, cirrhosis, and hepatocellular carcinoma. virus genotypes appear influence transmission dynamics, outcomes, responses antiviral therapy. However, hepatitis genotyping is poorly investigated topic in Sri Lanka. This study intended determine group HBV-infected persons central northern Methodology The was laboratory-based descriptive...
Introduction Hepatitis B infection causes a spectrum of clinical diseases varying from asymptomatic to severe or fulminant acute hepatitis, chronic liver disease, cirrhosis, and hepatocellular carcinoma. virus genotypes appear influence transmission dynamics, outcomes, responses antiviral therapy. However, hepatitis genotyping is poorly investigated topic in Sri Lanka. This study intended determine group HBV-infected persons central northern Methodology The was laboratory-based descriptive...
Introduction. Hepatitis B infection causes a spectrum of clinical diseases varying from asymptomatic to severe or fulminant acute hepatitis, chronic liver disease, cirrhosis and hepatocellular carcinoma. virus (HBV) genotypes appear influence transmission dynamics, outcomes responses antiviral therapy. However, hepatitis genotyping has been poorly investigated in Sri Lanka. This study intended determine group HBV-infected people central northern Methodology. The was laboratory-based...