A5067285717- Pregnancy and Medication Impact
- Electrolyte and hormonal disorders
- Pregnancy and preeclampsia studies
- Pharmacological Effects and Toxicity Studies
- Maternal Mental Health During Pregnancy and Postpartum
- GDF15 and Related Biomarkers
- Reproductive System and Pregnancy
- Folate and B Vitamins Research
- Eosinophilic Esophagitis
- Ion Transport and Channel Regulation
- Health, Medicine and Society
- Social Policies and Family
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- Nutrition and Health in Aging
- Delphi Technique in Research
- Science, Research, and Medicine
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Ion channel regulation and function
- Gastroesophageal reflux and treatments
- Vitamin D Research Studies
- Mobile Health and mHealth Applications
- Pregnancy-related medical research
- HIV/AIDS Research and Interventions
Education & Research Foundation
2014-2024
University of Southern California
2009-2023
Keck Hospital of USC
2022
University of California, Los Angeles
2016-2020
John Radcliffe Hospital
2011
Cambridge University Press
2011
New York University Press
2011
Chitose Institute of Science and Technology
2011
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2011
Institute of Cytology
2011
GDF15, a hormone acting on the brainstem, has been implicated in nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but full mechanistic understanding is lacking
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% pregnancies is associated with maternal fetal morbidity. The cause HG remains unknown, but familial aggregation results twin studies suggest that understanding the genetic contribution essential for comprehending disease etiology. Here, we conduct a genome-wide association study (GWAS) binary (HG) ordinal (severity vomiting) phenotypes pregnancy complications. Two loci, chr19p13.11 chr4q12, are significant...
Objective. Hyperemesis gravidarum (HG) can be accompanied by severe physical and emotional distress. Most studies have focused on the psychological stress associated with this condition during affected pregnancy. This study explores posttraumatic symptoms (PTSS) negative life outcomes following HG pregnancies.Methods. A total of 610 women (HG = 377 control 233) were recruited completed an online survey. χ-square analyses used to compare groups various outcome variables.Results. Eighteen...
To report the weight loss and associated symptoms experienced by a large cohort of women with hyperemesis gravidarum (HG).Data were obtained from an HG website registry, where recruited on-line. Respondents included if they at least 1 live birth>27 weeks' gestation. Extreme was defined as >15% prepregnancy weight.Of 819 surveyed, 214 (26.1%) met criteria for extreme loss. These twice likely to be Hispanic or nonwhite. (p<0.001) indicators severity HG, such hospitalization use parenteral...
Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs up to 2% of pregnancies leads significant weight loss, dehydration, electrolyte imbalance, ketonuria. It is associated with both maternal fetal morbidity. Familial aggregation studies twin suggest a genetic component. In recent GWAS, we showed that placentation, appetite, cachexia genes GDF15 IGFBP7 are linked hyperemesis gravidarum (HG). The purpose this study determine whether upregulated HG patients. Methods...
A genome-wide association study (GWAS) linked the placenta and appetite hormone gene GDF15 to hyperemesis gravidarum (HG). This paradigm-changing finding has shifted field away from prevailing hypotheses, but more evidence is needed. was performed identify coding variants in addition non-coding implicated by GWAS.Case-control research a university setting.Case-control study.Hyperemesis cases requiring intravenous fluid treatment for disease (n = 926) controls with normal or no nausea...
Objective: To identify factors associated with prolonged Hyperemesis Gravidarum (HG). Study Design: About 395 women completed a survey regarding pre-existing conditions, treatments and outcomes. Responses were compared using two-sided t-tests or the F-test. Results: Participants HG are slightly younger weigh more. Pre-existing include allergies restrictive diet. Prolonged is hematemesis, dizziness, fainting antiemetic treatment. Following pregnancy, those reported more posttraumatic stress,...
Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs up to 2% of pregnancies. It is associated with both maternal fetal morbidity. HG highly heritable recurs approximately 80% women. In recent genome-wide association study, it was shown that placentation, appetite, the cachexia gene GDF15 are linked HG. The purpose this study explore whether alleles overexpression protein segregate condition families, risk allele...
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, is characterized by long-term maternal stress, undernutrition dehydration. While stress malnutrition pregnancy are linked to poor neonatal outcome associated with adult health, fetal exposure HG has never been explored. The purpose this study determine whether emotional behavioral diagnoses may be HG. Emotional adults born a complicated were compared from non-exposed controls. Offspring exposed in utero significantly more...
Introduction: The purpose of this study is to describe the recurrence risk for hyperemesis gravidarum (HG). Methods: Women who registered on a Web site sponsored by Hyperemesis Education and Research Foundation as having had one HG‐complicated pregnancy were contacted follow‐up subsequent pregnancy. Participants completed an online survey. Results: One hundred women responded. Fifty‐seven become pregnant again, 2 trying conceive, 37 not willing get again because HG, 4 did have second other...
The purpose of this study was to describe the treatment women with hyperemesis gravidarum (HG). Women HG pregnancies at least 27 weeks duration occurring between 1985 and 2004 described their on an website from 2003 2005. usage effectiveness > 20 options were reported by 765 for 1193 pregnancies. who used intravenous (IV) hydration, serotonin inhibitors, parenteral nutrition (PN) highest rates effectiveness, 84%, 83%, 79% reporting that these respective treatments may have contributed...
Objective There are many uncertainties surrounding the aetiology, treatment and sequelae of hyperemesis gravidarum (HG). Prioritising research questions could reduce waste, helping researchers funders direct attention to those which most urgently need addressing. The HG priority setting partnership (PSP) was established identify rank top 25 important both patients clinicians. Methods Following James Lind Alliance (JLA) methodology, an PSP steering group established. Stakeholders representing...
Abstract Objective Hyperemesis gravidarum (HG) severity can be underestimated resulting in undertreatment and adverse outcomes. This study was conducted to validate a tool (HELP Score) designed score HG severity. Materials Methods A survey link which included PUQE HELP Score (HELP) questions posted on websites related HG. scores were compared for indicators of severe disease. Results classified 92% women reporting “nothing goes or stays down” as severe, 58% using PUQE. Women...
Introduction There is limited research on effective treatment of Hyperemesis Gravidarum (HG), the most extreme version nausea and vomiting during pregnancy (NVP). This paper examines current patterns use self-reported effectiveness cannabis/cannabis-based products (CBP) to treat HG. Materials/Methods The study employed a 21-question survey gather information demographics, antiemetic prescription use, experience with cannabis/CBPs among individuals who experienced or HG their pregnancy....
The aim of this study is to determine whether psychiatric symptoms affect recurrence risk hyperemesis gravidarum (HG).The sample included 108 women with HG treated i.v. fluids in their first pregnancy. Women were divided into two groups based on second Participants submitted medical records and completed a survey regarding pregnancy characteristics symptoms. χ(2) -test Student's t-test performed compare the groups.Eighty-four (71%) had requiring fluid for dehydration, compared 34 (29%) who...