A5088895032- SARS-CoV-2 and COVID-19 Research
- Radiopharmaceutical Chemistry and Applications
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- SARS-CoV-2 detection and testing
- Philosophical Ethics and Theory
- interferon and immune responses
- African history and culture studies
- Art, Politics, and Modernism
- CAR-T cell therapy research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
- Nietzsche, Schopenhauer, and Hegel
- Visual and Cognitive Learning Processes
- Protein Structure and Dynamics
- Ubiquitin and proteasome pathways
- Public Spaces through Art
- Land Rights and Reforms
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Nanoplatforms for cancer theranostics
- South African History and Culture
- Advanced Polymer Synthesis and Characterization
Queen's University Belfast
2019-2023
Institute of Cancer Research
2021
Indiana University School of Medicine
2020
University of Ulster
2020
Belfast City Hospital
2020
Durham University
2020
BTG International (United Kingdom)
2019
Liberty University
2012
Oxfam
1998
Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with interaction viral antigens angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking infection coronaviruses into human cells. We have implemented novel protein engineering technology to produce super-potent tetravalent form ACE2, coupled immunoglobulin γ1 Fc region, using self-assembling, tetramerization domain p53 protein. This high...
Anti-DLL4 VNAR targeted nanoparticles – a novel targeting ligand towards an under-investigated target.
Abstract Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 disease. Therapeutic antibodies are being developed that interact with viral spike proteins to limit infection of epithelium. We have applied a method dramatically improve performance anti-SARS-CoV-2 enhancing avidity through multimerization using simple engineering yield tetrameric antibodies. re-engineered six human p53 tetramerization domain, including three clinical trials casirivimab,...
Fluorescent dye encapsulation and release using mucoadhesive degradable thiol-functionalized amphiphilic block copolymer microparticles prepared by electrospraying.
High-affinity TCRs offer the potential to target chemotherapeutic drug-loaded nanoparticles specifically tumour cells expressing tumour-specific peptides minimising off-target effects.
Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.
Abstract Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with interaction viral antigens angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking infection coronaviruses into human cells. We have implemented novel protein engineering technology to produce super-potent tetravalent form ACE2, coupled immunoglobulin g1 Fc region, using self-assembling, tetramerization domain p53 protein....
Abstract Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 disease. Therapeutic antibodies are being developed that interact with viral spike proteins to limit infection of epithelium. We have applied a method dramatically improve performance anti-SARS-CoV-2 enhancing avidity through multimerization using simple engineering yield tetrameric antibodies. re-engineered six human p53 tetramerization domain, including three clinical trials casirivimab,...
This paper presents an algorithm, similar to implicit sphere tracing, that ray marches 3D non-convex shapes for efficient collision detection. Instead of finding points on the surface where individual rays strike, entire shape is marched in unison by a lower bound boundary distance, calculated at closest point between two surfaces. Advancing one towards other this new allows us identify contact few steps. method supports arbitrary nonconvex shapes, and can be run parallel. We apply...
Twentieth Century South Africa by W. Beinart. Oxford University Press, Cape Town and Oxford. 1994. xvi plus 293pp. Illicit Union: Scientific Racism in Modern Saul Dubow. Witwatersrand Johannesburg. 1995. xii 320pp. including bibliography index. Heart of Whiteness: Afrikaners Face Black Rule June Goodwin Ben Schiff. Scribner, New York. 415pp. US$27.50. Hard cover. Bridges to the Future: Prospects for Peace Security Southern Hans‐Joachim Spanger Peter Vale Westview Boulder, Colorado, xiv 195...
Land Law in Lesotho: The Politics of the 1979 Act (1995), by Anita Shanta Franklin. Avebury: Aldershot, 1995. (I) ‐ v111+206pp. Reviewed Motlatsi Thabane, National University Lesotho. Citizen and Subject: Contemporary Africa Legacy Late Colonialism (1996) Mahmood Mamdani. James Currey, ISBN 0–85255–399–4. Adam Leach.