A5039028657- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Porphyrin and Phthalocyanine Chemistry
- Biotin and Related Studies
- Synthesis and Properties of Aromatic Compounds
- Diabetes and associated disorders
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
- Microfluidic and Capillary Electrophoresis Applications
- Proteoglycans and glycosaminoglycans research
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- bioluminescence and chemiluminescence research
- Immune Cell Function and Interaction
- Infant Nutrition and Health
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- Bacteriophages and microbial interactions
- Surface Chemistry and Catalysis
- Organic and Molecular Conductors Research
Institute of Bioorganic Chemistry
2012-2021
University of Wrocław
2019-2020
Russian Academy of Sciences
2011-2013
National Academy of Sciences of Belarus
2009-2012
Chiral heteroaromatic propellers based on radially π-extended hexapyrrolohexaazacoronenes were obtained in a concise synthesis from suitably functionalized donor-acceptor monopyrroles. To overcome steric hindrance, new cyclodehydrogenation method was developed, and it uses bromine electrophiles as oxidative coupling agents instead of the commonly employed high-potential oxidants. The reaction offers high yields propeller-shaped targets, even for electron-deficient precursors, shows...
Abstract Chiral heteroaromatic propellers based on radially π‐extended hexapyrrolohexaazacoronenes were obtained in a concise synthesis from suitably functionalized donor–acceptor monopyrroles. To overcome steric hindrance, new cyclodehydrogenation method was developed, and it uses bromine electrophiles as oxidative coupling agents instead of the commonly employed high‐potential oxidants. The reaction offers high yields propeller‐shaped targets, even for electron‐deficient precursors, shows...
Azide and phosphoramidite functions were found to be compatible within one molecule stable for months in solution kept frozen at −20 °C. An azide-carrying was used direct introduction of multiple azide modifications into synthetic oligonucleotides. A series azide-containing oligonucleotides modified further using click reactions with alkynes.
Conductive π-conjugated polymers were electrochemically generated from a variety of donor–acceptor pyrroles containing fused perimidine subunits. Alternating oxidative and reductive polarization these precursors induces multidirectional coupling involving both acenaphtho[1,2-c]pyrrole moieties, producing cross-linked polymeric structures. Chemical oxidation experiments computational analyses spin densities in the charged pyrrole intermediates indicate that formation inter-perimidine linkages...
Oxidative transformation of hexapyrrolylbenzenes into azacoronenes using bromine electrophiles as alternative coupling agents is shown to occur according a distinct mechanism, different from those proposed for typical high-potential oxidants. It that consecutive cyclizations do not involve brominated intermediates and can be rationalized by assuming relayed arenium cation attack followed deprotonation conjugate elimination. The final cyclization incompatible with this mechanism found...
Innate immunity natural Abs (NAbs) execute a number of functions, including protection and surveillance. Despite active research, the stimuli that induce formation NAbs are still described only hypothetically. Here, we compared repertoires anti-glycan in peripheral blood mice received per os various bacteria. The primed this way were using microarray included about 350 glycans, as well 150 bacterial polysaccharides. Sterile did not possess Abs. Oral inoculation single strain or combination...
Despite considerable success studying glycan-binding proteins using printed glycan arrays (PGAs), unambiguous quantitation of spot intensities by fluorescent readers remains a challenge. The main obstacles are the varying shape and size in-spot fluorescence distribution caused uneven drying drops. Two methods have been suggested for solving this problem: polymeric glycoconjugates, which makes it possible to equalize physicochemical properties (hydrophobicity, charge, size) different glycans,...
Gastric cancer (GC) is traditionally considered a difficult disease to diagnose and treat. The search for new markers GC an extremely urgent purpose. Previously has been shown, that serum anti-glycan antibodies (AGAT) are very large reservoir of which can be reliably detected using instrument called glycoarray (PGA). A “;signature”; approach, i.e. searching combinations diagnostically significant – AGAT by PGA, used in this study. cohort the apparently healthy donors from National Medical...
Ein einfaches Reagens , N-Bromsuccinimid, ist das Oxidationsmittel der Wahl in stereospezifischen Synthese von Azacoronen-Propellern. Diese Familie chiraler Chromophore zeichnet sich durch kleine elektronische Bandlücken, eine vielseitige Redoxchemie und große chiroptische Signale aus, wie M. Stępień Mitarbeiter ihrer Zuschrift auf S. 4983 berichten.