A5045729475- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heme Oxygenase-1 and Carbon Monoxide
- Mesenchymal stem cell research
- Genetics and Neurodevelopmental Disorders
- Tea Polyphenols and Effects
- Immune cells in cancer
- Cardiac electrophysiology and arrhythmias
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- TGF-β signaling in diseases
- Natural product bioactivities and synthesis
- Neonatal Respiratory Health Research
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Adenosine and Purinergic Signaling
- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Studies
Qingdao University
2021-2023
Affiliated Hospital of Qingdao University
2021-2023
First People's Hospital of Jingzhou
2019
Xian Yang Central Hospital
2019
First Affiliated Hospital of Xinxiang Medical University
2013
Abstract Endothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the Epimedium plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. In this study, we investigated potential protective effect of icariin high glucose-induced detrimental effects vascular cells. Human umbilical venous cells were incubated in media containing 5.5 mM...
Mesenchymal stem cell (MSC) therapy is a promising treatment for diseases of the nervous system. However, MSCs often lose their stemness and homing abilities when cultured in conventional two‑dimensional (2D) systems. Consequently, it important to explore novel culture methods MSC-based therapies clinical practice. To investigate effect using chitosan membranes on MSCs, morphology was observed expression marker genes analyzed. We demonstrated that form spheroids. Additionally, genes,...
The mechanisms of cardiac toxicity caused by methamphetamine (MA) are poorly understood at present. This study was designed to investigate the effects MA on ionic currents in myocardial cells. transient outward potassium current (I(to)), inward rectifying (I(K1)), and L-type calcium (I(Ca-L)) isolated rat ventricular myocytes were studied using whole-cell patch clamp technique. It demonstrated that inhibited I(to), I(K1), I(Ca-L) concentration-dependently. shifted left I(to) steady-state...
Objective . The involvement of phosphodiesterase type 5 (PDE5) in the development insulin resistance has been reported recently. However, underlying molecular mechanism remains unclear. present study aims at investigating potential impacts PDE5A on signaling C2C12 skeletal muscle myotubes and uncover related mechanism. Methods myoblasts were differentiated into myotubes. Western blot was performed to detect levels proteins phosphorylated proteins. Glucose uptake determined by a colorimetric...
To observe the clinical efficacy and safety of Qingre Lishi decoction in treating newly diagnosed overweight obese patients with type 2 diabetes mellitus (T2DM) from an evidence-based medical perspective.
Oxidative stress injury (OSI) is an important pathological process in lung ischemia-reperfusion (LIRI), and diabetes mellitus (DM) can exacerbate this injury. Dexmedetomidine protects against LIRI by reducing OSI. However, the effect of dexmedetomidine on under diabetic conditions remains unclear. Therefore, study aimed at exploring effects mechanisms OSI induced rats. Rats were randomly divided into control+sham (CS), DM+sham (DS), control+ischemia-reperfusion (CIR), DM+ischemia-reperfusion...
Methane (CH 4 ) exerted protective effects against lung ischemia-reperfusion (I/R) injury, but the mechanism remains unclear, especially role of pulmonary surfactant. Therefore, this study aimed to explore CH inhalation on surfactant in rat I/R injury and elucidate mechanism. Rats were randomly divided into three groups ( n = 6): sham, control, groups. In sham group, only thoracotomy was performed rats. control groups, rats underwent left hilum occlusion for 90 min, followed by reperfusion...
Physicians' seniority has always been the focus of patients. Silver needle therapy (SNT) applied for more than 60 years. It is similar to moxibustion and a good therapeutic effect on soft tissue pain. This study aimed determine influence physicians' efficacy SNT patients with low back fasciitis.This was prospective cohort at Affiliated Hospital Qingdao University. Patients diagnosed fasciitis were split into junior physician (JP) senior (SP) groups (n = 30) based physician. The numerical...
Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells Sun S, Liu L, Tian X, Guo Y, Cao Mei Wang C. Planta Med 2019; 85: 473–482. doi:10.1055/a-0837-0975