- Balance, Gait, and Falls Prevention
- Effects of Vibration on Health
- Muscle activation and electromyography studies
- stochastic dynamics and bifurcation
- Neural dynamics and brain function
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Diabetic Foot Ulcer Assessment and Management
- Ecosystem dynamics and resilience
- Motor Control and Adaptation
- Prosthetics and Rehabilitation Robotics
- SARS-CoV-2 detection and testing
- Hearing, Cochlea, Tinnitus, Genetics
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Music Perception
- Stroke Rehabilitation and Recovery
- Biosensors and Analytical Detection
- Building Energy and Comfort Optimization
- Probabilistic and Robust Engineering Design
- Emotion and Mood Recognition
- Sports Performance and Training
- 3D Printing in Biomedical Research
- bioluminescence and chemiluminescence research
- Body Composition Measurement Techniques
Harvard University
2006-2021
Committee on Publication Ethics
2015
Creative Commons
2015
Columbia College
2010
Columbia University
2010
Cornell University
2010
Rhode Island Hospital
2010
Spaulding Rehabilitation Hospital
2006-2010
Royal College of Physicians
2010
Brown University
2003-2010
Somatosensory function declines with diabetic neuropathy and often stroke, resulting in diminished motor performance. Recently, it has been shown that input noise can enhance human sensorimotor function. The goal of this study was to investigate whether subsensory mechanical applied the soles feet via vibrating insoles be used improve quiet-standing balance control 15 patients stroke. Sway data 12 healthy elderly subjects from a previous on were added for comparison.Five traditional sway...
An integrated, low-cost, sample-to-answer, CRISPR-based diagnostic detects SARS-CoV-2 and variants from unprocessed saliva.
Noise can enhance the detection and transmission of weak signals in certain nonlinear systems, via a mechanism known as stochastic resonance. Here we show that input noise be used to improve motor control humans. Specifically, postural sway both young elderly individuals during quiet standing significantly reduced by applying subsensory mechanical feet. We further demonstrate with trend towards reduction subjects level subjects. These results suggest noise-based devices, such randomly...
Somatosensory information is critical to balance control and fall prevention in older adults. Recently, it has been shown that low-level input noise (electrical or mechanical) can enhance the sensitivity of human somatosensory system. In this study, we tested effect electrical noise, applied at knee, on 13 healthy elderly volunteers. Subjects performed multiple single-legged stance trials with imperceptible knee during half trials. Balance performance was characterized using a force platform...
Older adults often suffer from diminished somatosensation stemming age-related neuropathy. Recently, localized low-level electrical noise stimulation was shown to enhance tactile sensitivity in healthy young subjects. Here, we hypothesized that fine-touch older can be similarly improved. Semmes-Weinstein monofilaments were used evaluate on the first metatarsal phalangeal joint with four stimulus conditions and a null (no-noise) condition nine elderly Electrical resulted statistically...
OBJECTIVE—Localized low-level mechanical or electrical noise can significantly enhance tactile sensitivity in healthy young subjects and older adults. This phenomenon is termed stochastic resonance (SR). In this study, we examined the effect of SR on vibratory sensation patients with moderate to severe diabetic peripheral neuropathy. RESEARCH DESIGN AND METHODS—A total 20 were included study. The vibration perception threshold (VPT) test Semmes-Weinstein filament (SWF) at plantar surface...
Research teams at Afferent Corp. and Boston University have been collaborating to develop test a new class of neurotherapy devices that the promise directly improving mechanical sensory function help prevent falls in elderly foot injuries amputations people with diabetes. These are based on discovery certain forms electrical or stimulation applied mechanoreceptors increase their ability detect information. Results show best type signal is not finely tuned frequency but rather white noise....
Athletes incorporate afferent signals from the mechanoreceptors of their plantar feet to provide information about posture, stability, and joint position. Sub-threshold stochastic resonance (SR) sensory enhancing insoles have been shown improve balance proprioception in young elderly participant populations. Balance are correlated with improved athletic performance, such as agility. Agility is defined ability quickly change direction. An athlete's agility commonly evaluated during...
Acute application of stochastic resonance (SR), defined as a subsensory level mechanical noise presented directly to sensory neurons, improves the vibration and tactile perception in diabetic patients with mild moderate neuropathy. This study examined effect 1 hour continuous SR stimulation on nerve function. Twenty were studied. The was measured at 2 time points, beginning after 60 minutes continual stimulation. using threshold (VPT) big toe under conditions: null (no SR) condition active...
Inclined walking while carrying a loaded backpack induces fatigue, which may destabilize gait and lead to injury. Stochastic resonance (SR) technology has been used stabilize spatiotemporal characteristics of elderly individuals but not tested on healthy recreational athletes. Herein, we determined if sustained vigorous an inclined surface load destabilizes SR further effect.Participants were fitted with weighing 30% their body weight asked walk at constant self-selected pace feet tracked...
Previous studies have shown that subthreshold electrical or mechanical noise can reduce the sensory threshold and impart short-term improvements in sensorimotor function. We undertook this study to examine effects of combined subsensory vibratory stimulation conjunction with exercise training on long-term motor performance.Thirty subjects were recruited from adult community-dwelling stroke survivors residual hemiparesis. Subjects screened for ability using a functional task, those who...
Somatosensory function declines with age, and such changes have been associated postural instability. Recently, it has shown that input noise can enhance sensory motor function. PURPOSE: The goal of this study was to investigate whether subsensory mechanical applied the ankles via randomly vibrating wraps be used improve balance control in young elderly subjects. METHODS: Two quiet standing experiments were performed. Experiment 1 investigated application four different amplitudes find level...
0078 Diabetic patients with peripheral neuropathy have marked sensory deficits in the soles of their feet, which decreases ability to maintain balance during daily activities. Previous studies shown that subsensory mechanical noise (i.e., random vibration) applied feet significantly improves vibrotactile sensitivity and enhances posture control humans, via a mechanism known as stochastic resonance. PURPOSE: The goal this study was demonstrate quiet-standing postural sway diabetic can be...
Subsensory noise stimulation targeting sensory receptors has been shown to improve balance control in healthy and impaired individuals. However, the potential for application of this technique other contexts is still unknown. Gait adaptation rely heavily on input from proprioceptive organs muscles joints. Here we investigated use subsensory as a means influence motor by altering proprioception during locomotor adaptations forces delivered robot. The increase step length unilaterally trigger...
Balance is an important functional skill that greatly influences our ability to perform activities of daily living. Diminished balance ability, as demonstrated in older adults, can pose a serious health risk due the possibility falling. It has been shown recently control humans be enhanced by application mechanical noise feet. PURPOSE: We investigated whether electrical noise, when applied knee, enhance performance adults. METHODS: Thirteen healthy elderly adults (age 68–79 years) were asked...