A5083269730- Mosquito-borne diseases and control
- HIV Research and Treatment
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- interferon and immune responses
- Ion Channels and Receptors
- Genetics and Neurodevelopmental Disorders
- Herbal Medicine Research Studies
- Malaria Research and Control
- Heat shock proteins research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Medicinal Plants and Neuroprotection
- Wnt/β-catenin signaling in development and cancer
- COVID-19 epidemiological studies
- COVID-19 Pandemic Impacts
- Influenza Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
National Institute of Science Education and Research
2019-2024
Homi Bhabha National Institute
2022-2024
ICMR-National Institute of Virology
2019
All India Institute of Medical Sciences
2019
Government of India
2019
Institute of Life Sciences
2019
Post Graduate Institute of Medical Education and Research
2019
Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as major cellular reservoirs CHIKV during infection and this triggers robust TNF production macrophages, which might be key mediator induced inflammation. However, molecular mechanism underneath induction not understood yet. Accordingly, Raw264.7 cells, mouse macrophage cell line, were infected with to address above-mentioned question. It was observed that...
Toll like receptor 4 (TLR4), a pathogen-associated molecular pattern (PAMP) receptor, is known to exert inflammation in various cases of microbial infection, cancer and autoimmune disorders. However, any such involvement TLR4 Chikungunya virus (CHIKV) infection yet be explored. Accordingly, the role was investigated towards CHIKV modulation host immune responses current study using mice macrophage cell line RAW264.7, primary cells different origins vivo model. The findings suggest that...
Chikungunya virus (CHIKV) has reemerged as a global public health threat. The inflammatory pathways of the renin-angiotensin system (RAS) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) are usually involved in viral infections.
Being intracellular parasites, viruses require several host cell machineries for effectively replicating their genome, along with virus-encoded enzymes. One of the strategies involves hijacking DDR pathways.
Being obligate parasites, viruses use various host cell machineries in effectively replicating their genome, along with virus-encoded enzymes. In order to carry out infection and pathogenesis, are known manipulate fundamental cellular processes cells interfere gene expression. Several interact the proteins involved Wnt/β-catenin pathway; however, reports regarding involvement of protein components pathway Chikungunya virus (CHIKV) scarce. Additionally, there currently no remedies or vaccines...
Abstract Background Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions, including neuronal inflammation, neuropathic pain, and immunological responses. Heat shock protein 90 (Hsp90), a cytoplasmic molecular chaperone, is well-reported for cellular physiological processes. Hsp90 inhibition by molecules has garnered importance its therapeutic significance the downregulation of inflammation proposed as anti-cancer...
The increase in disease incidences and persistent Chikungunya virus (CHIKV)-induced arthritis have been a huge burden on public health globally. In the absence of specific antivirals or vaccines, it is essential to continue efforts develop effective anti-CHIKV strategies.
Abstract Viruses utilize a plethora of strategies to manipulate the host pathways and hijack its machineries for efficient replication. Several DNA as well handful RNA viruses are reported interact with proteins involved in damage responses (DDR). As DDR have never been explored Alphaviruses, this investigation intended determine importance CHIKV infection through vitro, vivo ex models. The study reveals that activates Chk2 Chk1 associated signaling increases by 95%. Inhibition both ATM-ATR...
ABSTRACT Chikungunya virus (CHIKV) has re-emerged as a global public health threat. The inflammatory pathways of RAS and PPAR-γ are usually involved in viral infections. Thus, Telmisartan (TM) with known capacity to block AT1 receptor activate PPAR-γ, was investigated against CHIKV. anti-CHIKV effect TM vitro (Vero, RAW 264.7 cells hPBMCs) vivo (C57BL/6 mice). found abrogate CHIKV infection efficiently (IC50 15.34-20.89µM the Vero respectively). Viral RNA proteins were reduced remarkably...