A5043971144- Tuberculosis Research and Epidemiology
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Virology and Viral Diseases
- Gene expression and cancer classification
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Immune responses and vaccinations
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Bioinformatics and Genomic Networks
- Biochemical Analysis and Sensing Techniques
- Viral gastroenteritis research and epidemiology
- Biochemical and Molecular Research
- melanin and skin pigmentation
- Genomics and Rare Diseases
- Scientific Computing and Data Management
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Animal Disease Management and Epidemiology
- Cancer-related molecular mechanisms research
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Rabies epidemiology and control
Centre for Development of Advanced Computing
2011-2025
Savitribai Phule Pune University
2016-2024
National AIDS Research Institute
2022
Indian Council of Medical Research
2022
Institute of Medical Sciences
2019
Indian Institute of Technology Guwahati
2019
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences
2019
Post Graduate Institute of Medical Education and Research
2019
Abstract Coronavirus disease 2019 emerged as the first example of “Disease X”, a hypothetical humans caused by an unknown infectious agent that was named novel coronavirus and subsequently designated severe acute respiratory syndrome 2 (SARS‐CoV‐2). The origin outbreak at animal market in Wuhan, China implies it case zoonotic spillover. study designed to understand evolution Betacoronaviruses particular diversification SARS‐CoV‐2 using RNA dependent polymerase (RdRp) gene, stable genetic...
Improved RNA virus understanding is critical to studying animal and plant health, environmental processes. However, the continuous rapid evolution makes their identification characterization challenging. While recent sequence-based advances have led extensive discovery, there growing variation in how viruses are identified, analyzed, characterized, reported. To this end, an RdRp Summit was organized a hybrid meeting took place Valencia, Spain May 2023 convene leading experts with emphasis on...
Fusarium wilt is one of the major biotic stresses reducing chickpea productivity. The use wilt-resistant cultivars most appropriate means to combat disease and secure As a step towards understanding molecular basis resistance in chickpea, we investigated transcriptomes wilt-susceptible under both oxysporum f.sp. ciceri (Foc) challenged unchallenged conditions. Transcriptome profiling using LongSAGE provided valuable insight into interactions between Foc, which revealed several known as well...
Large scale genome sequencing projects have produced huge datasets that pose challenges of high processing times especially for variant calling, a significant downstream analysis step. Efficient utilization computational resources accurate prediction in timely manner is possible using Hadoop MapReduce framework. We developed VIVIDHA (Variant Prediction and Visualization Interface Dynamic High-throughput Analysis), throughput methodology variants based on splitting the alignment file...
Mycobacterium tuberculosis (Mtb) is one of the world's successful pathogens that flexibly adapts its metabolic nature during infection host, and in response to drugs. Here we used genome scale modelling coupled with differential producibility analysis (DPA) translate RNA seq datasets into metabolite signals identified drug-associated profiles. We tested four TB drugs bedaquiline (BDQ), isoniazid (INH), rifampicin (RIF) clarithromycin (CLA); conducted experiments Mtb exposed individual at...
Kyasanur forest disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus (KFDV) was initially considered endemic to Western Ghats region Karnataka state in India. Over years, there have been reports its spread newer areas within and outside Karnataka. The absence an effective treatment for mandates need further research development novel vaccines. present study designed develop a multi-epitope vaccine candidate against KFDV using immunoinformatics approaches. A total 74...
BCG is the most widely used vaccine of all time and remains only licensed for use against tuberculosis in humans. also protects other species such as cattle tuberculosis, but due to its incompatibility with current tuberculin testing regimens unlicensed. BCG's efficacy relates ability persist host weeks, months or even years after vaccination. It unclear what degree this resist host's immune system maintained by a dynamic interaction between strain case pathogenic mycobacteria.
Abstract Bovine tuberculosis (BTB) caused by Mycobacterium bovis remains a major problem in both the developed and developing countries. Control of BTB UK is carried out test slaughter infected animals, based primarily on tuberculin skin (PPD). Vaccination with attenuated strain M. pathogen, BCG, not used to control bovine cattle at present, due its variable efficacy because it interferes PPD test. Diagnostic tests capable Differentiating Infected from Vaccinated Animals (DIVA) have been...
Mycobacterial cell envelope components have been a major focus of research due to their unique features that confer intrinsic resistance antibiotics and chemicals apart from serving as low-permeability barrier. The complex lipids secreted by Mycobacteria are known evoke/repress host-immune response thus contribute its pathogenicity. This study focuses on the comparative genomics biosynthetic machinery wall across 21-mycobacterial genomes available in GenBank release 179.0. An insight into...
The COVID-19 pandemic is a global challenge that impacted 200+ countries. India ranks in the second and third positions terms of number reported cases deaths. Being populous country with densely packed cities, SARS-CoV-2 spread exponentially. sequenced ≈0.14% isolates from confirmed for surveillance contributed ≈1.58% complete genomes globally. This study was designed to map circulating lineage diversity understand evolution using comparative genomics population genetics approaches. Despite...
Leprosy, caused by Mycobacterium leprae, has plagued humanity for thousands of years and continues to cause morbidity, disability stigmatization in two three million people today. Although effective treatment is available, the disease incidence remained approximately constant decades so new approaches, such as vaccine or drugs, are urgently needed control. Research however hampered pathogen's obligate intracellular lifestyle fact that it never been grown vitro. Consequently, despite...
Integration of voluminous omics data aids to unravel biological complexities associated with different disease phenotypes. Machine learning (ML) approaches provide insightful techniques for systematic multi-omics integration. In this study, survival prediction breast cancer patients was undertaken using 302 female from The Cancer Genome Atlas (TCGA). included gene expression, miRNA DNA methylation and copy number variation. Three computational multi-ensemble ML pipelines were tested Support...
Abstract Background Vitiligo is an auto-immune progressive depigmentation disorder of the skin due to loss melanocytes. Genetic risk one important factors for development vitiligo. Preponderance vitiligo in certain ethnicities known which can be analysed by understanding distribution allele frequencies across normal populations. Earlier GWAS identified 108 alleles Europeans and East Asians. In this study, 64 these were used analysing their enrichment depletion populations (1000 Genomes...
Breast cancer is one of the leading causes in women all over world and accounts for ~25% newly observed cancers women. Epigenetic modifications influence differential expression genes through non-coding RNA play a crucial role regulation. In present study, epigenetic regulation gene by in-silico analysis histone using chromatin immunoprecipitation sequencing (ChIP-Seq) has been carried out. Histone modification data H3K4me3 from normal-like four breast cell lines were used to predict miRNA...
ABSTRACT We report four full-genome sequences of bovine coronavirus (BCoV) isolates from dairy calves in Pennsylvania obtained 2016 and 2017. BCoV is a pathogen great importance to cattle health, this the first PA cattle.
Abstract Objectives MC1R polymorphisms have been reported to be under a selective constraint in populations inhabiting high UVR regions such as Africans; however, these patterns are not consistent. Here we analyze the gene West Maharashtra, India see if sequence diversity corresponds their diverse pigmentary profiles and is constrained dark skinned tribal compared lighter caste populations. Methods A 2648 bp region of this was sequenced 102 individuals data for π , ϴ indices. Tajima's D...
Objectives Reliable identification of population-specific variants is important for building the single nucleotide polymorphism (SNP) profile. In this study, genomic variation using allele frequency differences pharmacologically genes Gujarati Indians in Houston (GIH) and Indian Telugu U.K. (ITU) from 1000 Genomes Project vis-à-vis global population data was studied to understand its role drug response. Methods Joint genotyping approach used derive GIH ITU independently. SNPs both these...
Abstract Kyasanur Forest Disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus was initially considered endemic to Western Ghats region Karnataka. Still, over years, there have been reports its spread newer areas within and outside The absence an effective treatment for expedites need further research development novel vaccines. present study designed develop a multi-epitope vaccine candidate against KFDV using immunoinformatic tools. After analyzing 74 complete genome...