A5029373450- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Water Quality and Pollution Assessment
- Atmospheric and Environmental Gas Dynamics
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Genomics and Phylogenetic Studies
- Biochemical and Molecular Research
- Genomics and Rare Diseases
- Aquatic Ecosystems and Phytoplankton Dynamics
- Diagnosis and treatment of tuberculosis
- Pharmacological Effects of Natural Compounds
- Molecular Biology Techniques and Applications
- Fungal Biology and Applications
- Environmental Toxicology and Ecotoxicology
- Aquaculture Nutrition and Growth
- Gene expression and cancer classification
- Ichthyology and Marine Biology
- Biochemical Analysis and Sensing Techniques
- Helminth infection and control
- Water-Energy-Food Nexus Studies
- Genetic Associations and Epidemiology
- Slime Mold and Myxomycetes Research
- Water Resources and Management
- Groundwater and Isotope Geochemistry
Centre for Development of Advanced Computing
2011-2025
University of Burdwan
2016-2023
King Abdulaziz University
1996
National Botanical Research Institute
1994-1996
Central Inland Fisheries Research Institute
1969-1988
Mycobacterium tuberculosis (Mtb) is one of the world's successful pathogens that flexibly adapts its metabolic nature during infection host, and in response to drugs. Here we used genome scale modelling coupled with differential producibility analysis (DPA) translate RNA seq datasets into metabolite signals identified drug-associated profiles. We tested four TB drugs bedaquiline (BDQ), isoniazid (INH), rifampicin (RIF) clarithromycin (CLA); conducted experiments Mtb exposed individual at...
BCG is the most widely used vaccine of all time and remains only licensed for use against tuberculosis in humans. also protects other species such as cattle tuberculosis, but due to its incompatibility with current tuberculin testing regimens unlicensed. BCG's efficacy relates ability persist host weeks, months or even years after vaccination. It unclear what degree this resist host's immune system maintained by a dynamic interaction between strain case pathogenic mycobacteria.
Abstract Bovine tuberculosis (BTB) caused by Mycobacterium bovis remains a major problem in both the developed and developing countries. Control of BTB UK is carried out test slaughter infected animals, based primarily on tuberculin skin (PPD). Vaccination with attenuated strain M. pathogen, BCG, not used to control bovine cattle at present, due its variable efficacy because it interferes PPD test. Diagnostic tests capable Differentiating Infected from Vaccinated Animals (DIVA) have been...
Mycobacterial cell envelope components have been a major focus of research due to their unique features that confer intrinsic resistance antibiotics and chemicals apart from serving as low-permeability barrier. The complex lipids secreted by Mycobacteria are known evoke/repress host-immune response thus contribute its pathogenicity. This study focuses on the comparative genomics biosynthetic machinery wall across 21-mycobacterial genomes available in GenBank release 179.0. An insight into...
Leprosy, caused by Mycobacterium leprae, has plagued humanity for thousands of years and continues to cause morbidity, disability stigmatization in two three million people today. Although effective treatment is available, the disease incidence remained approximately constant decades so new approaches, such as vaccine or drugs, are urgently needed control. Research however hampered pathogen's obligate intracellular lifestyle fact that it never been grown vitro. Consequently, despite...
Abstract Background Vitiligo is an auto-immune progressive depigmentation disorder of the skin due to loss melanocytes. Genetic risk one important factors for development vitiligo. Preponderance vitiligo in certain ethnicities known which can be analysed by understanding distribution allele frequencies across normal populations. Earlier GWAS identified 108 alleles Europeans and East Asians. In this study, 64 these were used analysing their enrichment depletion populations (1000 Genomes...
Breast cancer is one of the leading causes in women all over world and accounts for ~25% newly observed cancers women. Epigenetic modifications influence differential expression genes through non-coding RNA play a crucial role regulation. In present study, epigenetic regulation gene by in-silico analysis histone using chromatin immunoprecipitation sequencing (ChIP-Seq) has been carried out. Histone modification data H3K4me3 from normal-like four breast cell lines were used to predict miRNA...
Summary Free ranging hamadryas baboons ( Papio ) in four localities the west and north of Saudi Arabia were examined for natural infection with Schistosoma mansoni. Faecal examination revealed S. mansoni on occasions within one year (at a prevalence rate 2.5‐4.0%) only locality, Al‐Baha area. The eggs viable, as shown by miracidial hatching tests, recorded at density 140–280 eggs/g faeces (7000–14000 eggs/day). Post‐mortem 13‐2.4 from each locality (adult worms tissue) area, 4.16%. Viable...
Anvaya is a workflow environment for automated genome analysis that provides an interface several bioinformatics tools and databases, loosely coupled together in coordinated system, enabling the execution of set analyses series or parallel. It client-server has advantage over existing software as it enables extensive pre & post processing biological data efficient manner. "Anvaya" offers user, novel functionalities to carry out exhaustive comparative via "custom tools," which are with new...
Objectives Reliable identification of population-specific variants is important for building the single nucleotide polymorphism (SNP) profile. In this study, genomic variation using allele frequency differences pharmacologically genes Gujarati Indians in Houston (GIH) and Indian Telugu U.K. (ITU) from 1000 Genomes Project vis-à-vis global population data was studied to understand its role drug response. Methods Joint genotyping approach used derive GIH ITU independently. SNPs both these...
A total of two lineages Mycobacterium tuberculosis var. africanum (Maf), L5 and L6, which are members the complex (MTBC), responsible for causing in West Africa. Regions difference (RDs) usually used delineation MTBC. With increased data availability, single nucleotide polymorphisms (SNPs) promise to provide better resolution. Publicly available 380 Maf samples were analyzed identification "core-cluster-specific-SNPs," while additional 270 validation. RD-based methods lineage-assignment,...
Abstract Background Mycobacterium tuberculosis var. bovis is one of the causative agents Tuberculosis primarily known to infect cattle and a member Complex. M.bovis zoonotic infects human other animals resulting in immense economic losses globally. often misdiagnosed becomes challenge for treatment recovery, as intrinsically resistant certain antibiotics. Hence, need accurate diagnostics tuberculosis. Results In order discern differences which lie between M.tuberculosis isolates we collected...
Aim: A comparative assessment of forest litterfall dynamics was carried out between the Garadaha (GF or urban) and Pratappur (PF pristine), located in Burdwan districts West Bengal, components were correlated with environmental factors that govern dynamics. Methodology: Nets dimension 1m × placed below tress both forests litter collected at regular intervals per month brought to laboratory for separation into categories like leaf litter, woody (bark), miscellaneous (mixed) twig. Two types...
Analyzing the data deluge generated by next generation sequencing technologies is a challenging task. Variant calling aids in characterizing phenotype of an organism. The objective this work to compare popular variant protocols available terms their accuracy for human and microbial genomes. Three read aligners viz. BWA-MEM, Bowtie2 NovoAlign were used genome benchmark dataset Genome Bottle (GIAB). was performed using four callers samtools-bcftools, VarScan2, GATK-HC DeepVariant. For genomes,...