Tychicus Chen

ORCID: 0000-0003-2146-9572
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About
Contact & Profiles
Research Areas
  • Peripheral Neuropathies and Disorders
  • Autoimmune Neurological Disorders and Treatments
  • Hereditary Neurological Disorders
  • Ophthalmology and Eye Disorders
  • Long-Term Effects of COVID-19
  • Brain Metastases and Treatment
  • Glycogen Storage Diseases and Myoclonus
  • Infectious Encephalopathies and Encephalitis
  • Neurological Complications and Syndromes
  • Multiple Sclerosis Research Studies
  • Ocular Diseases and Behçet’s Syndrome
  • Neurological and metabolic disorders
  • IgG4-Related and Inflammatory Diseases
  • Spinal Dysraphism and Malformations
  • Glioma Diagnosis and Treatment
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Ear and Head Tumors
  • Cervical and Thoracic Myelopathy
  • Epilepsy research and treatment
  • CNS Lymphoma Diagnosis and Treatment
  • Multiple Myeloma Research and Treatments
  • Vascular Malformations Diagnosis and Treatment
  • Genetic Neurodegenerative Diseases
  • Pharmacological Effects and Toxicity Studies

University of British Columbia
2020-2024

Universidad Braulio Carrillo
2024

Deleted Institution
2022

McGill University
2022

Creative Commons
2021

Stornoway Diamond (Canada)
2021

Spinal Cord Injury BC
2021

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10.1017/cjn.2024.50 article EN Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2024-04-02

ABSTRACT With virtual interviews for residency applications, program websites have become increasingly important resources applicants. We evaluated the comprehensiveness of US and Canadian neurology website, comparing this to published rankings best neurosurgery hospitals (for programs) number positions programs). were found be largely more comprehensive than websites, extensive associated with better fewer seats in US, regional differences present. recommend standardized guidelines increase...

10.1017/cjn.2023.266 article EN cc-by Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2023-08-04

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10.1017/cjn.2021.6 article EN Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2021-01-12

Pearls• Tolosa-Hunt syndrome (THS) is characterized by steroid-responsive painful ophthalmoplegia from idiopathic granulomatous inflammation of the cavernous sinus, superior orbital fissure, or orbit • THS falls under inflammatory (IOI) diseases, which also includes pseudotumor Visual impairment distinguishes lesions apex (optic nerve involvement) sinus Oysters

10.1212/wnl.0000000000207368 article EN Neurology 2023-04-25

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10.1017/cjn.2020.251 article EN Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2020-11-13

A 64-year-old man with a history of diabetes mellitus and end stage renal disease presented several day cognitive decline, reduced right eye visual acuity accompanied complete ophthalmoplegia in keeping orbital apex syndrome. Initial MRI was unremarkable other than mucosal thickening the frontal sinuses. He continued to clinically decline repeat revealed an edematous optic nerve lack enhancement within sinuses suspicion for invasive fungal infection. Given his diabetes, he started on...

10.1177/19418744211025369 article EN cc-by-nc The Neurohospitalist 2021-06-16

A 26-year-old man, right-handed, otherwise healthy warehouse worker presented with painless left-hand weakness. He noticed difficulty fine finger movements and thumb articulation that had been gradually worsening over the past 2 years. denied any sensory changes or involvement of other

10.1136/bcr-2021-246831 article EN BMJ Case Reports 2021-10-01

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10.1017/cjn.2023.330 article EN Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2024-01-05

To report the phenomenon of parakinesia brachialis oscitans (PBO) in a case tumefactive demyelination.

10.1212/wnl.0000000000206081 article EN Neurology 2024-04-09

To present a case of initially imaging-negative myelitis following COVID-19 infection, with repeat imaging demonstrating lateral tract longitudinally extensive responding to immunotherapy.

10.1212/wnl.0000000000205372 article EN Neurology 2024-04-09

A 73-year-old woman with JAK-2–positive polycythemia vera, myelodysplastic/myeloproliferative overlap disorder, and biopsy-proven extramedullary hematopoiesis (EMH) involving pleura paravertebral regions presented 6 weeks of headaches blurry vision. Examination showed bilateral papilledema, preserved acuity, mild right pyramidal weakness. MRI brain homogenously enhancing dural lesions no associated edema (figure). She underwent external beam radiation (10 fractions, 200 cGy/fraction) for...

10.1212/wnl.0000000000009926 article EN Neurology 2020-07-14

A woman in her 30s presented with progressive muscle rigidity, spasms, low back pain, gait difficulty and falls, over 5 years. Symptoms were initially attributed to functional neurological disorder the context of depression. Examination revealed rigidity axial lower limb muscles,

10.1136/bcr-2023-255008 article EN BMJ Case Reports 2023-03-01

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10.1017/cjn.2023.51 article EN cc-by Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2023-05-03

10.1017/cjn.2023.244 article EN Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2023-06-09

We present a case and video of 31-year-old man with biopsy-confirmed tumefactive demyelination affecting the right internal capsule causing left hemiplegia, excessive yawning, curious but well-described phenomenon parakinesia brachialis oscitans (PBO) transient tonic elevation his paralyzed arm while yawning. PBO is most commonly reported in ischemic stroke or pontomedullary brainstem lesions. Our uniquely demonstrates this demyelination. also highlight yawning which has been described...

10.1177/19418744231190143 article EN cc-by-nc The Neurohospitalist 2023-09-06

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10.1017/cjn.2020.282 article EN Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2021-01-05

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10.1017/cjn.2021.108 article EN cc-by-nc-nd Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2021-05-12

Immune checkpoint inhibitors (ICIs) are being used increasingly in the treatment of several cancers and have been associated with neurological complications including immune inhibitor-induced encephalitis (ICI-iE). We present two cases ICI-iE novel agent dostarlimab, which to our knowledge first reported this agent. These add growing body literature on ICI-iE, demonstrating meningoencephalitis dostarlimab treated successfully prednisone. As imaging studies may be unrevealing, clinicians must...

10.1016/j.ensci.2021.100356 article EN cc-by-nc-nd eNeurologicalSci 2021-07-13

A 46-year-old man presented with horizontal diplopia over 5 days. He had psoriatic arthritis that been stable on etanercept for several years but he interrupted treatment 3 months fear of immunosuppression during the coronavirus pandemic. restarted therapy before presentation after worsening arthritis. On examination, bilateral exotropia impaired adduction and gaze-evoked abducting nystagmus bilaterally, as well upgaze vertical (video 1). Pupillary responses, convergence facial strength were...

10.1136/practneurol-2021-003064 article EN Practical Neurology 2021-08-05

Abstract: Opsoclonus–myoclonus syndrome (OMS) is a rare characterized by opsoclonus, which irregular, spontaneous, multivectorial saccadic eye movements, along with diffuse or focal myoclonus and sometimes ataxia. OMS associated paraneoplastic etiologies in 20%–40% of cases, small-cell lung breast cancers the most common primary neoplasms adults, whereas neuroblastoma more children ovarian teratoma may occur women younger than 30 years. Onconeural antibodies are often not identified. In...

10.1097/wno.0000000000001384 article EN cc-by-nc-nd Journal of Neuro-Ophthalmology 2021-08-17

10.1177/1941874420977604 article DE The Neurohospitalist 2020-12-01

A 56-year-old man attended the emergency department with 2 days of right-sided frontal and supraorbital headache, a dull throbbing intermittent lancinating quality. He had photophobia but no phonophobia, nausea, vomiting or visual impairment. There was diplopia he did have discomfort on right lateral gaze. immunocompetent; his only relevant medical history familial hypercholesterolaemia requiring rosuvastatin. On examination, afebrile normal vital signs rash. ptosis pupils were equal...

10.1136/practneurol-2020-002870 article EN Practical Neurology 2021-01-28

10.1177/19418744211031360 article EN cc-by-nc The Neurohospitalist 2021-07-07

A 75-year-old man developed progressive right-hand weakness over 3 years. Examination revealed myelopathic hand, inverted radial reflex, and Wartenberg thumb reflex (Video 1). MRI demonstrated cervical spondylotic myelopathy (Figure). Surgical decompression stabilized symptoms.

10.1212/wnl.0000000000013262 article EN Neurology 2021-12-22
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