A5086313801- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Fibroblast Growth Factor Research
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pediatric health and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Nitric Oxide and Endothelin Effects
- Cystic Fibrosis Research Advances
- Tissue Engineering and Regenerative Medicine
- Data-Driven Disease Surveillance
- Renin-Angiotensin System Studies
- Connective tissue disorders research
- Organ Transplantation Techniques and Outcomes
- Proteoglycans and glycosaminoglycans research
- Misinformation and Its Impacts
University of Indonesia
2021
Vanderbilt University Medical Center
2013
KU Leuven
2009-2012
Rotterdam University of Applied Sciences
2005-2007
Erasmus University Rotterdam
2006
Erasmus MC
2005-2006
University Medical Center
2005
Azithromycin reduces airway inflammation and improves forced expiratory volume in 1 s (FEV ) chronic rejection or bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx). prophylaxis might prevent BOS. A double-blind randomised controlled trial of azithromycin (n = 40) placebo 43), initiated at discharge administered three times a week for 2 yrs, was performed 2005–2009 the Leuven University Hospital (Leuven, Belgium). Primary end-points were BOS-free overall survival yrs...
Remodeling of airways and blood vessels is an important feature in chronic obstructive pulmonary disease (COPD). By using immunohistochemical analysis, we examined bronchial expression patterns various extracellular matrix (ECM) components such as collagens (subtypes I, III, IV), fibronectin, laminin β2 patients with COPD (forced expiratory volume 1 second [FEV1] ≤75%; n = 15) without (FEV1 =≥85%; 16) correlated data lung function. Quantitative analysis revealed enhanced levels (P < .01)...
Chronic lung allograft dysfunction (CLAD) remains the leading cause of mortality after transplantation.In this retrospective single-center study, we aimed to identify different phenotypes and risk factors for CLAD diagnosis using univariate multivariate Cox proportional hazard survival regression analysis.CLAD was diagnosed in 71 294 patients (24.2%) at 30.9±22.8 months transplantation. Pulmonary function obstructive 51 (71.8%) patients, restrictive 20 (28.2%) whom 17 had persistent...
T helper 17 (Th17) cells can recruit neutrophils to inflammatory sites through production of IL-17, which induces chemokine release. IL-23 is an important inducer IL-17 and IL-22 production. Our aim was study the role Th17 in cystic fibrosis (CF) lung disease by measuring protein mRNA levels sputum clinically stable CF patients comparing these with healthy controls. Sputum induction performed adult outside exacerbation control subjects. IL-17A were measured supernatants cytometric bead array...
Abstract An important feature of chronic obstructive pulmonary disease (COPD) is airway remodelling, the molecular mechanisms which are poorly understood. In this study, role fibroblast growth factors (FGF‐1 and FGF‐2) their receptor, FGFR‐1, was assessed in bronchial wall remodelling patients with COPD (FEV 1 < 75%; n = 15) without > 85%; 16). FGF‐1 FGFR‐1 were immunolocalized epithelium, smooth muscle (ASM), submucosal glandular vascular muscle. Quantitative digital image analysis...
Almost all animal models for chronic rejection (CR) after lung transplantation (LTx) fail to resemble the human situation. It was our attempt develop a representative model of CR in mice. Orthotopic LTx performed allografts receiving daily immunosuppression with steroids and cyclosporine. Controls included isografts mice only undergoing thoracotomy (SHAM). Allografts were sacrificed 2, 4, 6, 8, 10 or 12 weeks LTx. Pulmonary function measured repeatedly 12w allografts, SHAM Histologically,...
Airway remodeling and associated angiogenesis are documented features of asthma, which the molecular mechanisms not fully understood. Angiotensin (ANG)II endothelin (ET)-1 potent vasoconstricting circulatory hormones implicated in asthma. We investigated effects ANG II ET-1 on human airway smooth muscle (ASM) cells proliferation growth examined mRNA expression release angiogenic peptide, vascular endothelial factor (VEGF). Serum deprived (48 h) ASM were incubated with (100 nM) or (10 for 30...
Remodeling of airways and blood vessels is an important feature in chronic obstructive pulmonary disease (COPD). By using immunohistochemical analysis, we examined bronchial expression patterns various extracellular matrix (ECM) components such as collagens (subtypes I, III, IV), fibronectin, laminin β2 patients with COPD (forced expiratory volume 1 second [FEV1] ≤75%; n = 15) without (FEV1 =≥85%; 16) correlated data lung function. Quantitative analysis revealed enhanced levels (P < .01)...
BACKGROUND. Reliable COVID-19 data are critical for understanding the disease and spread of pandemic, decision-making, developing implementing public health measures, tracking effectiveness interventions. Currently, however, there is a confusing plethora publicly available surveillance resources. Relevant websites frequently poorly designed making it extraordinarily time-consuming frustrating to find extract relevant information. METHODS. A systemic search government, official agency,...