A5042458857- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Genomics and Phylogenetic Studies
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Semiconductor Lasers and Optical Devices
- Lipid Membrane Structure and Behavior
- Microbial Natural Products and Biosynthesis
- Optical Systems and Laser Technology
- Photorefractive and Nonlinear Optics
- Immune Cell Function and Interaction
- Photoreceptor and optogenetics research
- Pharmacological Effects and Assays
- Biochemical and Molecular Research
- Advanced Optical Imaging Technologies
- Photonic and Optical Devices
- Cytomegalovirus and herpesvirus research
- Advanced Measurement and Detection Methods
- Immune Response and Inflammation
- Crystallization and Solubility Studies
- Photochromic and Fluorescence Chemistry
- Receptor Mechanisms and Signaling
- T-cell and B-cell Immunology
- Marine Toxins and Detection Methods
University of Groningen
2018-2024
Covestro (Germany)
2023-2024
Max-Planck-Institut für Kohlenforschung
2023
Leiden University
2015
The dinoflagellate-derived polyether prorocentin is a co-metabolite of the archetypical serine/threonine phosphatase inhibitor okadaic acid. Whereas structural relationship cannot be missed and biosynthetic link was proposed, it currently unknown whether there any parallel in bioactivity profile these natural products. However, insinuated past that structure assigned to might need revised. Indeed, re-examination published spectra cast doubts as constitution fused/spirotricyclic BCD-ring...
Abstract Crenarchaeol is a glycerol dialkyl tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane‐spanning undoubtedly structurally most sophisticated all known archaeal lipids and an iconic molecule organic geochemistry. The 66‐membered macrocycle possesses unique chemical structure featuring 22 mostly remote stereocenters, cyclohexane ring connected by single bond to cyclopentane ring. Herein we report first total synthesis proposed crenarchaeol....
Abstract CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and phospholipids, but were broadly cross-reactive diverse including phosphatidylcholine, phosphatidylinositol phosphatidylethanolamine. The crystal structure a representative TCR bound...
The first asymmetric total synthesis of three structures proposed for mycobacterial diacyl trehaloses, DAT1, DAT2, and DAT3 is reported. presence two these glycolipids, DAT1 DAT3, within different strains pathogenic M. tuberculosis was confirmed, it shown that their abundance varies significantly. In mass spectrometry, synthetic DAT2 possessed almost identical fragmentation patterns to presumptive from Mycobacterium H37Rv, but did not coelute by HPLC, raising questions as the precise...
The cell wall of Mycobacterium tuberculosis is composed diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms mycobacterial diacyltrehalose (DAT) that differ their fatty acid composition, DAT1, DAT2, and DAT3. study potential recognition DATs by T cells, treated lipid-binding antigen presenting molecule CD1b synthetic looked for cells bound complex. DAT1-...
Bayfol® HX photopolymer films prove themselves as easy-to-process recording materials for volume holographic gratings (VHGs) and are available in customized grade at industrial scale. Their full-color (RGB) replay capabilities two of their major advantages. Moreover, the adjustable diffraction efficiency, tunable angular spectral selectivity VHGs recorded into Bayfol<sup>®</sup> well unmatched optical clarity enables superior invisible "Off-Bragg" functionality. As a film product,...
Bayfol<sup>®</sup> HX photopolymer films prove themselves as easy-to-process recording materials for volume holographic optical elements (vHOEs) and are available in customized grade at industrial scale. Their full-color (RGB) replay capabilities two of their major advantages. Moreover, the adjustable diffraction efficiency, tunable angular spectral selectivity vHOEs recorded into well unmatched clarity enables superior invisible "off Bragg" functionality. As a film product, replication can...
Abstract. Soil bacteria rank among the most diverse groups of organisms on Earth and actively impact global processes carbon cycling, especially in emission greenhouse gases like methane, CO2 higher gaseous hydrocarbons. An abundant group soil are mycobacteria, which colonize various terrestrial, marine anthropogenic environments due to their impermeable cell envelope that contains remarkable lipids. These have been found be highly at petroleum gas seep areas, where they might utilize...
DAT
Abstract DAT 2 is a member of the diacyl trehalose family (DAT) antigenic glycolipids located in mycomembrane Mycobacterium tuberculosis ( Mtb ). Recently it was shown that molecular structure had been incorrectly assigned, but correct remained elusive. Herein, and its methyl‐branched acyl substituent mycolipanolic acid determined. For this, four different stereoisomers were prepared stereoselective unified manner, incorporated into . A rigorous comparison isomers to isolated from H37Rv by...
Bayfol® HX photopolymer films prove themselves as easy-to-process recording materials for volume holographic optical elements (vHOEs) and are available in customized grade at industrial scale. Their full-color (RGB) replay capabilities two of their major advantages. Moreover, the adjustable diffraction efficiency, tunable angular spectral selectivity vHOEs recorded into well unmatched clarity enables superior invisible "off Bragg" functionality. As a film product, replication can be carried...
Bayfol<sup>®</sup> HX photopolymer films prove themselves as easy-to-process recording materials for volume holographic optical elements (vHOEs) and are available in customized grade at industrial scale. Their full-color (RGB) replay capabilities two of their major advantages. Moreover, the adjustable diffraction efficiency, tunable angular spectral selectivity vHOEs recorded into well unmatched clarity enables superior invisible "off Bragg" functionality. As a film product, replication can...
The pre-association mechanism of an ion-pair Type II photoinitiating system (PIS) acting in the visible range was studied. choice a dye as photoinitiator (crystal violet) with excited state lifetime 200 ps ensured absence dynamical quenching by borate salts used coinitiators. In spite fact that no diffusional bimolecular can take place, excellent polymerization efficiency found, underlining high reactivity PIS. A saturation effect is observed when increasing concentration consequence arising...
Abstract Crenarchaeol is a glycerol dialkyl tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane‐spanning undoubtedly structurally most sophisticated all known archaeal lipids and an iconic molecule organic geochemistry. The 66‐membered macrocycle possesses unique chemical structure featuring 22 mostly remote stereocenters, cyclohexane ring connected by single bond to cyclopentane ring. Herein we report first total synthesis proposed crenarchaeol....
Abstract. Soil bacteria rank among the most diverse groups of organisms on Earth and actively impact global processes carbon cycling, especially in emission greenhouse gases like methane, CO2 higher gaseous hydrocarbons. An abundant group soil are mycobacteria, which colonize various habitats due to their impermeable cell envelope that contains remarkable lipids. These have been found be highly at petroleum gas seep areas, where they might utilize released However, function lipid biomarker...
This study describes the first asymmetric total synthesis of proposed structure archaeal membrane-spanning tetraether lipid crenarchaeol. The synthetic material was compared by NMR and GC-MS analysis with natural Detailed ultimately enabled revision crenarchaeol, identifying one out 22 sterecenters to be inverted.
This study describes the first asymmetric total synthesis of proposed structure archaeal membrane-spanning tetraether lipid crenarchaeol. The synthetic material was compared by NMR and GC-MS analysis with natural Detailed ultimately enabled revision crenarchaeol, identifying one out 22 sterecenters to be inverted.