A5102762547- Epigenetics and DNA Methylation
- Viral Infections and Outbreaks Research
- Radical Photochemical Reactions
- vaccines and immunoinformatics approaches
- Click Chemistry and Applications
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Advanced biosensing and bioanalysis techniques
University of Freiburg
2023-2024
University of Basel
2021
Abstract Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that enzymatic activity was required tumour cell proliferation identified KMT9 as a potential therapeutic target. Here, report development potent selective inhibitor (compound 4, KMI169) with cellular through structure-based drug design. KMI169 functions...
The C-type lectin receptor DC-SIGN is a pattern recognition expressed on macrophages and dendritic cells. It has been identified as promiscuous entry for many pathogens, including epidemic pandemic viruses such SARS-CoV-2, Ebola virus, HIV-1. In the context of recent SARS-CoV-2 pandemic, DC-SIGN-mediated virus dissemination stimulation innate immune responses implicated potential factor in development severe COVID-19. Inhibition binding to DC-SIGN, thus, represents an attractive...
We developed a facile photoreductive and stereoselective β-aminoalkylation of crowded enone by blue LED light irradiation using wide variety α-amino acids in order to access 5'-amino substituted carbasugar nucleosides for SAM-based methyltransferase inhibitors. This photochemical method provides highly functionalized mimics nucleoside analogue synthesis.