A5073730032- Tea Polyphenols and Effects
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Medical Image Segmentation Techniques
- Genomics and Rare Diseases
- Immunodeficiency and Autoimmune Disorders
- RNA regulation and disease
- Brain Tumor Detection and Classification
- Genetics and Neurodevelopmental Disorders
- Advanced Neural Network Applications
- Simulation and Modeling Applications
- Radiomics and Machine Learning in Medical Imaging
- Fatty Acid Research and Health
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- High-Voltage Power Transmission Systems
- Lung Cancer Research Studies
- Hereditary Neurological Disorders
- Phytochemicals and Antioxidant Activities
- HVDC Systems and Fault Protection
- DNA Repair Mechanisms
- Real-time simulation and control systems
- Cancer, Lipids, and Metabolism
- Silicon Carbide Semiconductor Technologies
Henan Cancer Hospital
2023
Zhengzhou University
2023
Georgetown University
2018-2022
Georgetown University Medical Center
2018-2022
North China Electric Power University
2020
Background BCL11B encodes B cell lymphoma/leukemia 11B, a transcription factor that participates in the differentiation and migration of neurons lymphocyte cells. De novo mutations have been associated with neurodevelopmental disorder immunodeficiency. These were identified patients Immunodeficiency 49 (IMD49) or Intellectual developmental speech delay, dysmorphic facies, T-cell abnormalities (IDDSFTA). However, pathogenesis these two types deficiency is still mysterious. The strategy to...
DnaA, the initiator of Escherichia coli chromosomal replication, has in its adenosine triphosphatase (ATPase) domain residues required for 5'-triphosphate (ATP) binding and membrane attachment. Here, we show that D118Q substitution DnaA linker domain, a known to be without major regulatory functions, influences ATP replication initiation vivo. Although defective by itself, overexpression DnaA(D118Q) caused overinitiation dnaA46ts cells prevented cell growth. The growth defect was rescued...
Obesity is associated with cancer risk and its link liver particularly strong. causes non-alcoholic fatty disease (NAFLD) that could progress to hepatocellular carcinoma (HCC). Chronic inflammation likely plays a key role. We carried out bioassay in the high-fat diet (HFD)-fed C57BL/6J mice provide insight into mechanisms of obesity-related HCC by studying γ-OHPdG, mutagenic DNA adduct derived from lipid peroxidation. In an 80-week bioassay, received low-fat (LFD), (HFD), HFD 2% Theaphenon E...
To compare Whole-brain radiation therapy with simultaneous integrated boost (WBRT+SIB) to stereotactic radiosurgery (SRS)for non-small cell lung cancer (NSCLC)with brain metastases (BMs)in terms of overall survival (OS), intracranial progression-free-survival(iPFS), toxicity and objective response rate (ORR).A retrospective review was performed in our hospital 90 patients diagnosed NSCLC- BM who received either SRS (n = 48) or WBRT+SIB 42) from January 2016 2022. 76 (84.44%) systemic drug...
Accurate segmentation of brain tumors plays a key role in the diagnosis and treatment tumor diseases. It serves as critical technology for quantifying extracting their features. With increasing application deep learning methods, computational burden has become progressively heavier. To achieve lightweight model with good performance, this study proposes MBDRes-U-Net using three-dimensional (3D) U-Net codec framework, which integrates multibranch residual blocks fused attention into model....
Background: Duchenne muscular dystrophy (DMD) and Becker (BMD) are two subtypes of diseases caused by pathogenic mutations in the DMD gene. Until now, more than 4,600 disease-causing have been reported. However, only 33 were deep intronic, cases with this type limited. Methods: In study, we used a combination complementary DNA (cDNA) target sequencing analysis addition to conventional whole-exome (WES). Results: Three novel hemizygous IVS11 + 17811C > G (c.1331 G), IVS21 3252A (c.2803...
Objective Patients with pancreatic cancer (PC) have a poor prognosis. Radiotherapy (RT) is standard palliative treatment in clinical practice, and there no effective prediction model to predict the prognosis of PC patients receiving radiotherapy. This study aimed analyze PC’s characteristics, find factors affecting patients’ prognosis, construct visual Nomogram overall survival (OS). Methods SEER*Stat software was used collect data from Surveillance, Epidemiology, End Results (SEER) database...
Lipid peroxidation of polyunsaturated fatty acids (PUFAs) is an endogenous source α,β-unsaturated aldehydes that react with DNA producing a variety cyclic adducts. The mutagenic adducts, specifically those derived from oxidation ω-6 PUFAs, may contribute to the cancer promoting activities associated PUFAs. ( E)-4-Hydroxy-2-nonenal (HNE) unique product PUFAs oxidation. HNE reacts deoxyguanosine (dG) yielding 1, N2-propanodeoxyguanosine adducts (HNE-dG). Earlier studies showed can also be...
Background: Leukoencephalopathy with cerebral calcifications and cysts (LCC) is a rare autosomal recessive microangiopathy. Recently, biallelic variants in non-protein-coding gene SNORD118 have been discovered to cause LCC. Case Presentation: We here report genetically confirmed childhood case of The patient was 4-year-and-1-month-old boy focal seizures. age at onset his seizure 10 days after birth. seizures were well-controlled by antiepileptic treatment but reoccurred twice due head impact...
The control system structure of modular multilevel converter based high voltage direct current (MMC-HVDC) is complicated. Data acquisition, computation, and communication among distributed controllers lead to long link delay. delay will further cause deterioration the system's dynamic characteristics even instability. This paper presents an integrated controller design on field programmable gate array (FPGA). parallel features FPGA are fully utilized complete calculation task shorten as much...
To summarize the clinical phenotype and genotype of a Chinese child affected with Mowat-Wilson syndrome (MWS).Clinical data patient were collected. The was analyzed by whole-exome sequencing (WES) as well Sanger sequencing.The male infant recurrent fever slow growth. He also had characteristic facies, spasm, growth retardation. WES revealed that he has carried heterozygous nonsense c.2609C>G (p.Ser870X) variant ZEB2 gene (30% mosaicism). Based on American College Medical Genetics Genomics...
<p>Supplementary tables and figures for study</p>
<div>Abstract<p>Obesity is associated with cancer risk and its link liver particularly strong. Obesity causes non-alcoholic fatty disease (NAFLD) that could progress to hepatocellular carcinoma (HCC). Chronic inflammation likely plays a key role. We carried out bioassay in the high-fat diet (HFD)-fed C57BL/6J mice provide insight into mechanisms of obesity-related HCC by studying γ-OHPdG, mutagenic DNA adduct derived from lipid peroxidation. In an 80-week bioassay, received...
<div>Abstract<p>Obesity is associated with cancer risk and its link liver particularly strong. Obesity causes non-alcoholic fatty disease (NAFLD) that could progress to hepatocellular carcinoma (HCC). Chronic inflammation likely plays a key role. We carried out bioassay in the high-fat diet (HFD)-fed C57BL/6J mice provide insight into mechanisms of obesity-related HCC by studying γ-OHPdG, mutagenic DNA adduct derived from lipid peroxidation. In an 80-week bioassay, received...
<p>Supplementary tables and figures for study</p>