A5036381541- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- HIV/AIDS oral health manifestations
- Oral and gingival health research
- Dental Health and Care Utilization
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Salivary Gland Disorders and Functions
- Infective Endocarditis Diagnosis and Management
- Periodontal Regeneration and Treatments
- Drug-Induced Adverse Reactions
- Dental materials and restorations
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- NF-κB Signaling Pathways
- Dental Implant Techniques and Outcomes
- Antimicrobial Peptides and Activities
- Digestive system and related health
- Herpesvirus Infections and Treatments
- Cleft Lip and Palate Research
Centro Universitario de Araras Dr Edmunso Ulson
2017-2023
Universidade Estadual de Campinas (UNICAMP)
2011-2021
Methodist University of Piracicaba
2013
Objective The present study assessed the effect of smoking on clinical, microbiological and immunological parameters in an experimental gingivitis model. Material Methods Twenty‐four healthy dental students were divided into two groups: smokers ( n = 10); nonsmokers 14). Stents used to prevent biofilm removal during brushing. Visible plaque index VPI ) gingival bleeding GBI determined 5‐ day ‐7 (running phase), baseline, 21 d (experimental gingivitis) 28 (resolution phase). Supragingival...
Background: The aim of the present study is to evaluate periodontal clinical and microbiologic responses possible adverse effects clarithromycin (CLM) combined with mechanical therapy in treatment patients generalized aggressive periodontitis. Methods: Forty were selected randomly assigned into one two groups: 1) CLM (n = 20): one‐stage full‐mouth ultrasonic debridement (FMUD) associated (500 mg, every 12 hours for 3 days); 2) placebo FMUD pills. Clinical parameters evaluated at baseline 6...
Abstract Aim Generalized aggressive periodontitis ( GAP ) is a severe and multifactorial disease in which familial aggregation specific microbiological profile have been suggested. Thus, this case–control study evaluated the clinical subgingival microbial of subjects their families compared to healthy families. Methods Fifteen with parents presenting periodontal health 15 history were selected. Each family should at least one child between 6 12 years old. Plaque index PI ), gingival GI...
The objective of this study was to investigate the antibacterial effect resveratrol against putative periodontal pathogens during progression experimental periodontitis in rats. Periodontitis induced rats one first molars chosen receive a ligature. Animals were assigned two groups: daily administration placebo solution (control group, n = 12) or 10 mg/Kg (RESV 12). therapies administered systemically for 30 days, 19 days before induction and then another 11 days. Then, presence...
Abstract Objective To evaluate clinical and radiographic characteristics in peri‐implant marginal tissues patients with a history of chronic periodontitis, rehabilitated using tissue‐level or bone‐level implants. Material Methods Using split‐mouth design, 20 periodontitis were selected received two different implants, group ( n = 20) the 20). Peri‐implant probing depth, relative mucosal margin position, attachment level, plaque index bleeding on evaluated at prosthesis installation, 1, 3, 6,...
This randomized, blinded, placebo-controlled clinical trial compared the levels of interferon γ (IFN-γ), prostaglandin E2 (PGE2), and interleukin 6 (IL-6) in gingival crevicular fluid (GCF) from generalized aggressive periodontitis (GAgP) patients treated with nonsurgical therapy associated or not amoxicillin/metronidazole adjunctive.Thirty-nine GAgP were followed during months. The randomly allocated to one groups: experimental (scaling root planing plus 375 mg amoxicillin 250 metronidazole...
The colonization and accumulation of Streptococcus mutans are influenced by various factors in the oral cavity, such as nutrition hygiene conditions host, salivary components, cleaning power flow characteristics related with microbial virulence factors. Among these factors, ability to synthesize glucan adhesion, glucan-binding proteins, lactic acid bacteriocins could modify infection process pathogenesis this species dental biofilm. This review will describe role mutacins transmission,...
Generalized aggressive periodontitis (GAgP) presents a reduced response to non-surgical therapy. However, it is not clear if the initial clinical, microbiological or immunological characteristics are impacting worse treatment. This study aimed identify predictive value of and patterns on clinical therapy in GAgP patients. Twenty-four patients were selected, gingival crevicular fluid (GCF) subgingival biofilm collected. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis...
Aggressive periodontitis (AgP) is influenced by genetic factors. Recently, the single nucleotide polymorphisms (SNPs) rs1537415 (GLT6D1), rs6667202 (IL10), and rs1333048 (ANRIL) were associated with AgP in different European populations. However, these specific SNPs have not yet been determined Brazilians. Therefore, this study investigated whether previously could be replicated among Brazilians.The rs1537415, rs6667202, genotyped using 5'-nuclease allelic discrimination assay (n = 200),...
Background Generalized aggressive periodontitis ( GAP ) is a multifactorial disease that shows specific microbial profile and familial aggregation. Aim This study evaluated the salivary of families with history compared them healthy families. Design Fifteen parents presenting periodontal health 15 were selected. Each family had child aged 6–12 years. Stimulated saliva was collected from all subjects, Porphyromonas gingivalis (Pg) , Tannerella forsythia (Tf), Aggregatibacter...
Abstract Background This study evaluates the transcriptome of healthy gingival tissue from edentulous sites in patients with a history generalized aggressive periodontitis (GAgP), chronic (CP), and no (H), using microarray quantitative reverse transcription polymerase chain reaction (qRT‐PCR) analysis. Methods Healthy was taken GAgP (n = 12), CP H 12) groups. Initially, total RNA four samples per group used transcriptomic Differential gene expression (fold‐change), ontology (GO; biologic...
Aggressive periodontitis (AgP), currently grade C, presents early onset, rapid progression, and a poorly established genetic association. Thus, this study aimed to identify variants associated with AgP via whole exome sequencing (WES) through familial screening approach.WES was performed in two nuclear families, including proband parent affected by an unaffected sibling. Common among individuals, excluding those common healthy people, from each family, composed the data set AgP. In silico...
Periodontitis Stage III-IV, Grade C (PerioC) is a severe form of Periodontitis. The individual genetic background has been shown to be an important etiopathogenic factor for the development this disease in young, systemically healthy, and non-smokers patients. Recently, after exome sequencing families with history disease, PerioC was associated three single nucleotide variations (SNVs) - rs142548867 (EEFSEC), rs574301770 (ZNF136), rs72821893 (KRT25) which were classified as deleterious or...
Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature this disease etiology. Aim: This study aimed to evaluate, vivo, the functionality SNP on IL-10 gingival fluid levels. Methods: Thirty patients with Perio4C were selected, 15 AA genotype (rs6667202) AC/CC genotypes. The was collected from two sites probing depth ≥ 7 mm bleeding probing, healthy sites....
Este estudo teve como principal objetivo investigar se os polimorfismos de nucleotídeo único (SNP) foram significantemente associados com a periodontite agressiva (PA) na população brasielira.A frequencia dos SNPs rs1537415 (GLT6D1), rs6667202 (IL10
Fatores genéticos influenciam o desenvolvimento e a progressão da periodontite agressiva (PA), ao promover alterações na resposta imune-inflamatória do hospedeiro. Recentemente polimorfismo de nucleotídeo único (SNP) rs6667202 localizado região reguladora gene IL10 foi associado com PA em uma população brasileira, apresentando um carater protetor à sua ocorrência. Porém, impacto presença desse SNP produção local (fluído crevicular gengival) IL-10 pacientes não havia sido investigada até...
Este estudo investigou se a variação de nucleotídeo único (SNV) rs142548867 no gene EEFSEC foi significativamente associada com periodontite agressiva (PA) em uma população brasileira. A frequencia do SNV analisada 200 indivíduos PA e sem histórico (SP). Como resultado observado que este associado na estudada, sendo o alelo raro detectado mais frequentemente nos PA, tornando risco para ocorrência da doença.