A5064609189- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Semiconductor materials and devices
- Physics of Superconductivity and Magnetism
- Advancements in Semiconductor Devices and Circuit Design
- Vestibular and auditory disorders
- Surface and Thin Film Phenomena
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Force Microscopy Techniques and Applications
- Advanced X-ray and CT Imaging
- Nuclear Physics and Applications
- Migraine and Headache Studies
- Quantum and electron transport phenomena
- Radiation Therapy and Dosimetry
- Ultrasonics and Acoustic Wave Propagation
- Theoretical and Computational Physics
- Ophthalmology and Eye Disorders
- Neurological disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Semiconductor materials and interfaces
- 3D IC and TSV technologies
- Hemoglobinopathies and Related Disorders
University of North Carolina at Chapel Hill
2011
North Carolina State University
2011
Duke University
1995-2005
Duke Medical Center
1993-2005
RTI International
2005
Baylor University Medical Center
1999
Yale New Haven Hospital
1998
General Electric (United States)
1986-1995
Duke University Hospital
1995
Princeton University
1995
Abstract Magnetic resonance images of the lungs a guinea pig have been produced using hyperpolarized helium as source MR signal. The resulting are not yet sufficiently optimized to reveal fine structural detail within lung, but spectacular signal from this normally signal‐deficient organ system offers great promise for eventual in vivo imaging experiments. Fast 2D and 3D GRASS sequences with very small flip angles were employed conserve nonrenewable longitudinal magnetization. We discuss...
Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3 gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences and small flip angles ( < 10 degrees). Thick-section (20 mm) coronal images, time-course data (30 images collected every 1.8 seconds), thin-section (6 were acquired. Subjects able to breathe the (12% polarization) without difficulty. good quality a signal-to-noise ratio (S/N) 32:1 near surface coil 16:1 farther away....
A high-temperature superconducting-receiver system for use in nuclear magnetic resonance (NMR) microscopy is described. The scaling behavior of sources sample and receiver-coil noise analyzed, it demonstrated that Johnson, or thermal, the receiver coil factor limits resolution. superconductors environment an NMR experiment examined, a prototypical imaging biological specimens discussed. Preliminary spin-echo images are shown, ultimate signal-to-noise ratio probe investigated.
The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange rubidium metal vapor was delivered an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired ventilation-gated, radial k-space sampling showed complete ventilation both lungs. All were high quality, demonstrating that allows high-signal-intensity MR imaging in living systems.
Objective To evaluate the safety and efficacy of a novel solid‐state, caloric vestibular stimulation (CVS) device to provide adjuvant therapy for prevention episodic migraine in adult migraineurs. Background Migraine causes significant disability ∼12% world population. No current preventive treatment provides full clinical relief, many exhibit high rates discontinuation due adverse events. Thus, new therapeutic options are needed. CVS may be an effective safe adjuvant‐therapy migraine....
Working from the periphery on Djaara Country, Castlemaine Regional Victoria,140km out of Melbourne, our proposal starts centre this old gold mining town and seeks to document capture more-than-architectural endeavour. For narrative, architect’s business is as much about observing taking note, revealing paying heed invisible often intangible systems just what’s there now. Drawing a Kraussian expanded architectural field, we have evolved design process building site knowledge context that...
An implantable radiation dosimeter for use with external beam therapy has been developed and tested both in vitro canines. The device uses a MOSFET is polled telemetrically every day during the course of therapy. designed permanent implantation also acts as radiographic fiducial marker. Ten dogs (companion animals) that presented spontaneous, malignant tumors were enrolled study received an implant tumor CTV. Three additional collateral normal tissue. Radiation plans created animals they...
Measurements of several properties $\frac{1}{f}$ noise in $n$-type silicon-on-sapphire wafers were made the temperature range 100-330 K. The resistance fluctuations nearly scalar, independent temperature. magnitude Hall-effect was larger than that predicted for simple carrier-number at 100 and 140 K, but less 300 correlation between Hall resistivity had same sign slightly lower would be expected majority-carrier number fluctuations. Temperature-dependent features spectrum showed kinetics...
The conductivity fluctuations giving $\frac{1}{f}$ noise in bismuth were found to be extremely nonscalar, with local instantaneous anisotropy between that of dyads and traceless tensors. This result requires a symmetry-breaking noise-generating mechanism. Temperature dependence detailed spectral data show the kinetics are thermally activated net magnitude thick films is decreasing function temperature. A crude model accounting for these results presented.
Intravesical BCG (bacillus Calmette-Guérin) instillation is a first-line treatment for superficial transitional cell carcinoma of the bladder. A rare but severe complication immunotherapy development disseminated disease, which can result in miliary pneumonitis, granulomatous hepatitis, soft tissue infections, bone marrow involvement, and sepsis. Symptoms present as early few hours or late several months following therapy. The key finding disease formation caseating granulomas distant...
Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings aid diagnosis of balance disorders and confirm absence brainstem function. While a number studies have hinted at potential therapeutic applications CVS, limitations existing devices frustrated that potential. Current CVS irrigators use water or air during short-duration applications; however, this approach is not tenable for longer duration protocols home use. Here, we describe...
Two statistical tests of 1/f noise—histograms noise power in time-frequency windows and covariance matrices separate octave bands—were used to determine deviations from Gaussian statistics. In silicon, bismuth, some carbon granule resistors no non-Gaussian effects were found. One resistor showed clear behavior. The significance the results for models origins is discussed.
The $\frac{1}{f}$ noise found in continuous films of chrome and bismuth is to lack space-time cross-spectral components the 1-Hz---1-mm range. not due either temperature fluctuations or transported with charge carriers.
We describe a model of neurological disease based on dysfunctional brain oscillators. This is not new model, but it one that widely appreciated by clinicians. The value this lies in the predictions makes and utility provides translational applications, particular for neuromodulation devices. Specifically, we provide perspective devices input to sensory receptors thus stimulate endogenous networks. Current forms clinically applied neuromodulation, including such as (implanted) deep...
A 31-year-old wo man diagnosed with Lyme disease was treated amoxicillin. One hour after the first antibiotic dose, patient became acutely ill. She developed hypertension, fever, and rigors. Shortly afterward, she hypotensive required fluid resuscitation. This systemic illness, Jarisch-Herxheimer reaction, noted in association therapy for neurosyphilis. Thus, institution of may be complicated by reaction.
This paper describes an improved UMOSFET with ultralow specific on-resistance. device utilizes a self-aligned process that permits closely spaced vertical trench gates unit cell of 6 µm. allows for remarkable increase channel density and, therefore, reduces the on-resistance per area significantly. Experimental devices have been fabricated, and 1.0 mΩ . cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> breakdown voltage 30 V has...
We report on electrical noise measurements made YBCO (Y1 Ba2 Cu3 O7−x ) films SrTiO3, bulk silicon with a ZrO2 buffer layer, and thin dielectric membranes. have found that 1/f predominates in the unoriented thermal fluctuation is chief source of good SrTiO3 .
There has been a good deal of interest recently in the applicability thermal bonding to silicon-on-insultator (SOI) technology. Thermal (also called direct bonding) is accomplished by mating polished, properly hydrolyzed silicon and/or dioxide surfaces, which are then annealed promote diffusion bonding. In order produce high-quality SOI layers it must be demonstrated that interface betweeen wafers void-free over entire surface wafer (4-in. our study). We have found standard annealing step...
The magnitude of 1/ f noise in an ordinary wafer lightly doped n-type silicon lacking impurity scattering is found to be three orders less than the commonly accepted value. conductivity fluctuations causing are spatially uncorrelated and approximately scalar, as might expected for a simple trapping model. Varying surface treatments were increase noise, sometimes clear association with slight I-V nonlinearities, but no sample had resistance more one tenth large predicted by Hooge relation.