A5049471038- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Plasma Applications and Diagnostics
- Pulsed Power Technology Applications
- Toxin Mechanisms and Immunotoxins
- Magnetic and Electromagnetic Effects
- Cellular Mechanics and Interactions
- Heat shock proteins research
- Cancer Cells and Metastasis
- Transgenic Plants and Applications
UNC/NCSU Joint Department of Biomedical Engineering
2018-2024
North Carolina State University
2022-2024
High frequency irreversible electroporation (H-FIRE) is an emerging cancer therapy which uses bursts of alternating polarity pulses to target and destroy the membranes cells within a predictable volume. Typically, 2 µs are rapidly repeated 24-50 times create 48-100 long energy burst. Bursts 100× at 1 Hz, resulting in integrated energized time 0.01 s per treatment. A 3D vitro tumor model was used investigate H-FIRE parameters search optimal timing protocols. Monopolar IRE treatments (100 ×...
Objective: To demonstrate the feasibility of a single electrode and grounding pad approach for delivering high frequency irreversible electroporation treatments (H-FIRE) in in-vivo hepatic tissue. Methods: Ablations were created porcine liver under surgical anesthesia by adminstereing bursts 0.5-5.0 μs pulses with amplitudes between 1.1-1.7 kV absence cardiac synchronization or intraoperative paralytics. Finite element simulations used to determine electric field strength associated ablation...
This study sought to investigate a novel strategy using temperature-controlled delivery of nanosecond pulsed electric fields as an alternative the 50-100 microsecond pulses used for irreversible electroporation.
To evaluate the effect of a closed-loop temperature based feedback algorithm on ablative outcomes for pulsed electric field treatments.A 3D tumor model glioblastoma was used to assess impact 2 μs duration bipolar waveforms viability following exposure open and protocols. Closed-loop treatments evaluated transient increases 5, 10, 15, or 22 °C above baseline.The controlled ablation diameters were conditionally different than open-loop generally produced smaller ablations. control enabled...
To study the safety and efficacy of algorithmically controlled electroporation (ACE) against spontaneous equine melanoma.
Expanding the volume of an irreversible electroporation treatment typically necessitates increase in pulse voltage, number, duration, or repetition. This study investigates addition polyethylenimine nanoparticles (PEI-NP) to pulsed electric field treatments, determining their combined effect on ablation size and voltages. U118 cells vitro 3D cell culture model were treated with one three parameters (with without PEI-NPs) which are representative (IRE), high frequency (H-FIRE), nanosecond...