The goal of this study is to provide a seizure detection algorithm that relatively simple implement on microcontroller, so it can be used for an implantable closed loop stimulation device. We propose set 11 time domain and power bands features, computed from one intracranial EEG contact located in the onset zone. classification features performed using random forest classifier. Depending training datasets optimization preferences, performance were: 93.84% mean sensitivity (100% median...

Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for focal epilepsy. A major appeal of LITT that it may result in fewer cognitive deficits, especially when targeting dominant hemisphere mesial temporal lobe (MTL) To evaluate this, as well to determine seizure outcomes following LITT, we evaluated the relationships between ablation volumes and or 43 consecutive patients undergoing MTL epilepsy.All underwent unilateral structures. FreeSurfer software was...

Reading a sentence entails integrating the meanings of individual words to infer more complex, higher-order meaning. This highly rapid and complex human behavior is known engage inferior frontal gyrus (IFG) middle temporal (MTG) in language-dominant hemisphere, yet whether there are distinct contributions these regions reading still unclear. To probe neural spatiotemporal dynamics, we used direct intracranial recordings measure activity while sentences, meaning-deficient Jabberwocky lists or...

The cingulate cortex is part of the limbic system. Its function and connectivity are organized in a rostro-caudal ventral-dorsal manner which was addressed by various other studies using rather coarse cortical parcellations. In this study, we aim at describing its invasive recordings from patients explored for focal drug-resistant epilepsy. We included that underwent stereo-electroencephalographic intracranial electrodes University Emergency Hospital Bucharest between 2012 2019. reviewed all...

Abstract Objective Lexical retrieval deficits are characteristic of a variety different neurological disorders. However, the exact substrates responsible for this not known. We studied large cohort patients undergoing surgery in dominant temporal lobe medically intractable epilepsy ( n = 95) to localize brain regions that were associated with anomia. Methods performed multivariate voxel‐based lesion–symptom mapping analysis correlate surgical lesions within changes naming ability....

Language depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations spatiotemporal resolution have previously rendered it difficult isolate processes involved in integration. We utilized intracranial recordings epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential a common object. Semantically sentences enabled high frequency broadband gamma activation (70-150 Hz)...

Reading words aloud is a fundamental aspect of literacy. The rapid rate at which multiple distributed neural substrates are engaged in this process can only be probed via techniques with high spatiotemporal resolution. We direct intracranial recordings covering most the left hemisphere 46 humans (26 male, 20 female) as they read regular, exception and pseudo-words. used to create map word processing derive how broadband γ activity varies attributes critical reading speed: lexicality,...

The stereoelectroencephalographic (SEEG) implantation procedures still represent a challenge due to the intrinsic complexity of method and number depth electrodes required.We aim at designing evaluating accuracy custom stereotactic fixture based on StarFix™ technology (FHC Inc., Bowdoin, ME) that significantly simplifies optimizes used in presurgical evaluation patients with drug-resistant epilepsy.Fiducial markers also serve as anchors for are implanted into patient's skull prior surgery. A...

Cortical direct electrical stimulation (DES) is a method of brain mapping used during invasive presurgical evaluation patients with intractable epilepsy. Intellectual auras like intrusive thoughts, also known as forced thinking (FT), have been reported frontal seizures. However there are few reports on FT obtained DES in cortex. We report three cases which we thoughts while stimulating the dorsolateral prefrontal cortex and white matter region. In order to highlight effective connectivity...

To qualify the incidence of and risk factors for visual field deficits (VFD) following laser interstitial thermal ablation (LITT) mesial temporal lobe epilepsy (MTLE) to relate this anterior lobectomy (ATL).Fifty-seven patients underwent LITT amygdalo-hippocampal complex (AH) MTLE. Masks volumes, probe trajectories, radiations (VRs) from individual subject space were transformed into standardized using nonlinear registration. Voxel-wise statistics performed model relationships between VFDs...

The success of stereoelectroencephalographic (SEEG) investigations depends crucially on the hypotheses putative location seizure onset zone. This information is derived from non-invasive data either based visual analysis or advanced source localization algorithms. While applied to interictal spikes recorded scalp classical method, it does not provide unequivocal regarding Raw ictal activity contains a mixture signals originating several regions brain as well EMG artifacts, hampering direct...

Summary Objective Epilepsy is characterized by transient alterations in brain synchronization resulting seizures with a wide spectrum of manifestations. Seizure severity and risks for patients depend on the evolution spread hypersynchronous discharges. With standard visual inspection pattern classification, this could not be predicted early on. It still unclear to what degree seizure onset zone determines severity. Such information would improve our understanding ictal epileptic activity...

Body awareness is the result of sensory integration in posterior parietal cortex; however, other brain structures are part this process. Our goal to determine how cingulate cortex involved representation our body. We retrospectively selected patients with drug-resistant epilepsy, explored by stereo-electroencephalography, that had sampled outside epileptogenic zone. The clinical effects high-frequency electrical stimulation were reviewed and only those sites elicited changes related body...

Abstract Reading is a rapid, distributed process that engages multiple components of the ventral visual stream. However, neural constituents and their interactions allow us to identify written words are not well understood. Using direct intracranial recordings in large cohort humans, we comprehensively isolated spatiotemporal dynamics word recognition across entire left occipitotemporal cortex. The mid-fusiform cortex first region sensitive identity both sub-lexical lexical frequencies. Its...

Chronic migraine (CM) is a highly debilitating disease, and many patients remain refractory to medicinal therapy. Given the convergent nature of neuronal networks in ventral posteromedial nucleus (VPM) evidence sensitization pain circuitry this we hypothesize CM rats will have increased VPM firing, which can be attenuated using occipital nerve stimulation (ONS).To determine whether firing frequency differs between sham rats, ONS significantly alters rates during application mechanical...

Investigating cognitive brain functions using non-invasive electrophysiology can be challenging due to the particularities of task-related EEG activity, depth activated areas, and extent networks involved. Stereoelectroencephalographic (SEEG) investigations in patients with drug-resistant epilepsy offer an extraordinary opportunity validate information derived from recordings at macro-scales. The SEEG approach provide activity high spatial specificity during tasks that target specific...

High-frequency oscillations >80 Hz (HFOs) have unique features distinguishing them from spikes and artefactual components that can be well evidenced in the time-frequency representations. We introduce an unsupervised HFO detector uses computer-vision algorithms to detect landmarks on 2D maps. To validate detector, we analytical model of based a sinewave having Gaussian envelope, for which equations space derived, allowing us establish direct correspondence between common detection criteria...

Magnetic resonance imaging (MRI)-negative epilepsy may be successfully solved with a multidisciplinary approach using invasive recordings, image and signal analysis. The whole methodology used by the surgery team is systematically described based on an resistant case all steps rationale of choosing different investigation methods from surface electroencephalography (EEG) to recordings. Due negative MRI non-concordant ictal EEG clinical semiology, patient was investigated stereo- (SEEG),...