A5067002813- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Advanced Synthetic Organic Chemistry
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Axial and Atropisomeric Chirality Synthesis
- Chemical Reactions and Isotopes
- Hepatitis C virus research
- Biochemical and Molecular Research
- Asymmetric Hydrogenation and Catalysis
- Analytical Chemistry and Chromatography
- HIV/AIDS drug development and treatment
- Advanced biosensing and bioanalysis techniques
- Magnetism in coordination complexes
- Cytokine Signaling Pathways and Interactions
- Mosquito-borne diseases and control
- Lanthanide and Transition Metal Complexes
- Metal-Catalyzed Oxygenation Mechanisms
- Cyclopropane Reaction Mechanisms
- Coordination Chemistry and Organometallics
- Synthesis and biological activity
- Prion Diseases and Protein Misfolding
- Plant-based Medicinal Research
- Neurological diseases and metabolism
Lomonosov Moscow State University
2005-2024
Moscow State University
2012-2016
The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using dimethyl sulfoxide as a reagent for synthesis labelled heterocycles and trideuteromethylated compounds. A broad scope developed method various scaffolds was
We have developed an efficient and stereoselective route to trans-fused octahydrocyclohepta[b]pyrrol-4(1H)-ones. The key features of our synthesis include the regioselective epoxide ring-opening alkynyl oxiranes a aza-Cope-Mannich reaction. target compounds were prepared in 3-6 steps from commercially available starting materials (61-75% overall yield) with minimal chromatographic purification. devised using Shi epoxidation or (R)-1-phenylethylamine as source chirality.
Medicinal chemists are keen to explore tridimensional compounds, especially when it comes small molecules. It has already been stressed that the majority of known drugs tend be flat, whereas natural products more and represent a good source active compounds. 3D metrics have implemented computational descriptors available evaluate prioritize compounds based on their geometry. This is usually done by comparing saturated carbon atoms in molecule with total number its non-hydrogen (the Fsp3...
Abstract Evolutionary potential of viruses can result in outbreaks well‐known and emergence novel ones. Pharmacological methods intervening the reproduction various less popular, but not important are available, as well spectrum antiviral activity for most known compounds. In framework chemical biology paradigm, characterization new compounds allows to extend space provides structure–activity relationships data‐driven drug discovery. Here we present a primary assessment spiro‐annulated...
Into the fold: Prion diseases are neurodegenerative disorders characterized by accumulation in brain of a self-replicating, misfolded isoform (PrPSc) cellular prion protein (PrPC). No therapies available for these pathologies. We capitalized on previously described cell-based assays to screen library small molecules, and identified 55, compound capable counteracting both replication toxicity. Compound 55 may represent starting point development completely new class therapeutics diseases....
Herein, we report the synthesis of substituted morpholino nucleoside derivatives starting from ribonucleosides. The present protocol shows high functional group tolerance, uses mild reaction conditions, and gives moderate to good yields. This transformation is based on two sequential pathways: (i) oxidation ribonucleosides corresponding dialdehyde using sodium periodate (ii) reductive amination in situ generated dialdehydes with hydrochloride salts various alkylamines.
The development of novel methods and strategies for the formation fused five-, six-, seven-membered ring structures is utmost importance in organic syntheses.
Исполнительское искусство Е. А. ЛУКЬЯНЕНКОРостовская государственная консерватория им.С. В. Рахманинова
Homoleptic complexes [Fe(4bt)
Background: Herpesviruses cause a variety of infections, ranging from localized inflammation to severe disease and malignancies. The current portfolio anti-herpes drugs is limited, often accompanied by significant side effects, prolonged use can lead viral resistance. This study investigates the antiviral activity newly synthesized compounds against cytomegalovirus (CMV) herpes simplex virus (HSV). Methods: Saturated heterocyclic with annelated or spiro rings have been using either...
Abstract Key steps of the process are regioselective epoxide ring‐opening alkynyl oxirane (I) and stereoselective aza‐Cope—Mannich reaction.
The title chiral compound, C(23)H(28)NO(+)·Br(-), was obtained from an optically active amino-ethanol precursor. pyrrolidine heterocycle has envelope conformation, with the C atom α-positioned respect to keto group deviating by 0.570 (6) Å mean plane of other atoms. trans-fused seven-membered ring adopts a pseudo-chair conformation. two phenyl rings form dihedral angle 85.1 (2)°. cationic center and bromide anion are connected through N-H⋯Br hydrogen bond.