A5082494651- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Effects of Environmental Stressors on Livestock
- Milk Quality and Mastitis in Dairy Cows
- Sperm and Testicular Function
- Ruminant Nutrition and Digestive Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Animal Behavior and Welfare Studies
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Agriculture Sustainability and Environmental Impact
- Single-cell and spatial transcriptomics
- Animal Genetics and Reproduction
- Renal and related cancers
- Probiotics and Fermented Foods
- Telomeres, Telomerase, and Senescence
- Digestive system and related health
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Animal health and immunology
- Fatty Acid Research and Health
- Food Supply Chain Traceability
- Lipid metabolism and biosynthesis
- Animal Disease Management and Epidemiology
Federico II University Hospital
2014-2025
University of California, Irvine
2025
University of Naples Federico II
1994-2024
Division of Undergraduate Education
2021
Western General Hospital
2019-2020
Institute of Genetics and Cancer
2018-2020
University of Edinburgh
2018-2020
Significance Statement The innate immune system is central to injury and repair in the kidney, but heterogeneity of myeloid cell subsets behind these processes unknown. Complementary technologies—including bulk tissue transcriptomics, integrated droplet– plate-based single-cell RNA sequencing, paired blood exchange—resolved a murine model reversible unilateral ureteric obstruction, creating atlas. identified novel could be targeted ameliorate or enhance repair, including an Arg1+ monocyte...
Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent are not considered functionally distinct endpoints. Using single-cell analysis, we observed two transcriptional endpoints, endpoint marked by Ras Notch activation. We find oncogene-induced in vitro vivo requires Notch, rather than SASP...
This Research Communication describes the association between genetic variation within prolactin (PRL) gene and milk production traits of Italian Mediterranean river buffalo (Bufala mediterranea Italiana). High resolution melting (HRM) techniques were developed for genotyping 465 buffaloes. The polymorphism with was performed subsequently effects parity calving season evaluated. Single nucleotide polymorphisms (SNPs) identified at exons 2 5 introns 1 2. All SNPs in Hardy-Weinberg...
The mammary gland is the production organ in mammals that of great importance for milk and quality. However, characterization buffalo transcriptome identification valuable candidate genes affect limited. Here, we performed differential expressed (DEGs) analysis tissue on day 7, 50, 140, 280 after calving conducted gene-based genome-wide association studies (GWAS) yield 935 Mediterranean buffaloes. We then employed weighted gene co-expression network (WGCNA) to identify specific modules hub...
Wet-aging (WA) and dry-aging (DA) methods are usually used in the beef industry to satisfy consumers' tastes; however, these not suitable for all anatomical cuts. In this study, WA DA were applied improve quality of two cuts Charolais (Longissimus dorsi Semitendinosus). For 60 days (i.e., 2 days, 15 30 sampling), a physicochemical, rheological, microbiological analysis performed at (vacuum packed; temperature 4 ± 1 °C) (air velocity 0.5 m/s; °C; relative humidity 78 10%) conditions. The...
In the last years, livestock sector is moving towards a more sustainable animal-based industry, mitigating environmental impact of while meeting demand for high-quality food. To achieve these goals, farms are using technological approach, adopting algorithms to manipulate vast amount data from sensors and routine operations. The results will be useful making objective decisions. this context, machine learning - branch Artificial Intelligence applied study prediction, inference, clustering...
Fertility is a complex trait that has major impact on the development of buffalo industry. Genome-wide association study (GWAS) increased ability to detect genes influencing traits, and many important related reproductive traits have been identified in ruminants. However, are influenced by factors. The follicle one most internal processes affecting fertility. Genes found GWAS be associated with follicular may directly affect present combined RNA-seq granulosa cells identify which fertility...
The aim of this study is to combine advanced GC-MS and metabolite identification in a robust repeatable technology platform characterize the metabolome buffalo milk mozzarella cheese. utilized eleven dairies located protected designation origin (PDO) region nine non-PDO Italy. Samples raw (100 mL) cheese g) were obtained from each dairy. A total 185 metabolites consistently detected both PLS-DA score plots clearly differentiated PDO samples. For samples, it was possible divide into two...
The effect of crocin in the semen extender before cryopreservation was evaluated on sperm parameters 20 bucks five different breeds: Garganica (GA), Jonica (JO), Maltese (MA), Mediterranean Red (MR) and Saanen (SA). Semen samples were centrifuged, to remove seminal plasma, divided two aliquots diluted with Tris-egg-yolk-based extender, containing 0 (control group) 1 mM crocin. Crocin concentration established after a preliminary dose trial. On fresh frozen-thawed sperm, motility, viability,...
Nutrition impacts the epigenetic signature, including DNA methylation. The aim of this study was to identify genomic regions differentially methylated in rumen Italian Mediterranean dairy buffaloes fed green forage [Total Mixed Ration (TMR) + ryegrass feed (30% diet)] compared those receiving a standard TMR diet, through Reduced Representation Bisulfite Sequencing. We found 6571 (DMRs), 51.73% hypomethylated and 48.27% hypermethylated. DMRs were uniformly dispersed genes intergenic along...
Betaines are food components widely distributed in plants, animals, microorganisms, and dietary sources. Among betaines, δ-valerobetaine (N,N,N-trimethyl-5-aminovaleric acid, δVB) shares a metabolic pathway common to γ-butyrobetaine (γBB). The biological properties of δVB particularly attractive, as it possesses antioxidant, anti-inflammatory anticancer activities. Here, we investigated the possible synergism between structurally related γBB, date unexplored, by testing vitro activity head...
The temperature–humidity index (THI) has been commonly used to analyse heat stress in dairy cattle, but little is known about its effects on buffaloes. In this study, daily milk yield (MY), fat percentage (FP), protein (PP) and somatic cell count (SCC) data from 808 buffalo cows plus environmental temperature relative humidity were investigate the consequence of stress. Two mixed models evaluate impact THI MY, FP, PP log transformed SCC (SCS). effect was significant for PP, FP SCS, whereas...