A5016157021- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Semiconductor materials and devices
- Copper Interconnects and Reliability
- Electronic Packaging and Soldering Technologies
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Bioinformatics and Genomic Networks
- Advancements in Photolithography Techniques
- Environmental Monitoring and Data Management
- Lipid metabolism and biosynthesis
- Enzyme Catalysis and Immobilization
- Reproductive Physiology in Livestock
- Animal Behavior and Reproduction
- Biomedical and Engineering Education
- Genetics, Bioinformatics, and Biomedical Research
- Fungal and yeast genetics research
- Research Data Management Practices
- Scientific Computing and Data Management
- 3D IC and TSV technologies
- Evolution and Genetic Dynamics
- Plant Pathogens and Resistance
Humboldt-Universität zu Berlin
2016-2022
Humboldt State University
2016
Infineon Technologies (Germany)
2012
GlobalFoundries (Germany)
2011
University of Stuttgart
2009
Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate comprehensive models of complex cells.We organized the 2015 Whole-Cell Modeling Summer School teach WC evaluate need new standards software by recoding recently published model in Systems Biology Markup Language.Our analysis revealed several challenges representing using current standards.We, therefore, propose standards, software,...
: SBtab is a table-based data format for Systems Biology, designed to support automated integration and model building. It uses the structure of spreadsheets defines conventions table structure, controlled vocabularies semantic annotations. The comes with predefined types experimental SBML-compliant structures can easily be customized cover new data.SBtab documents created edited any text editor or spreadsheet tool. website www.sbtab.net provides online tools syntax validation conversion...
Abstract Systems Biology is an approach to biology and medicine that has the potential lead a better understanding of how biological properties emerge from interaction genes, proteins, molecules, cells organisms. The aims at elucidating these interactions govern function by employing experimental data, mathematical models computational simulations. As inherently multidisciplinary, education within this field meets numerous hurdles including departmental barriers, availability all required...
Lipid metabolism is essential for all major cell functions and has recently gained increasing attention in research health studies. However, mathematical modeling by means of classical approaches such as stoichiometric networks ordinary differential equation systems not yet provided satisfactory insights, due to the complexity lipid characterized many different species with only slight differences promiscuous multifunctional enzymes. Here, we present an object-oriented stochastic model...
The cell division cycle in eukaryotic cells is a series of highly coordinated molecular interactions that ensure growth, duplication genetic material, and actual are precisely orchestrated to give rise two viable progeny cells. Moreover, the machinery responsible for incorporating information about external cues or internal processes must keep track coordinated, timely progression all related processes. This most pronounced multicellular organisms, but also cardinal feature model organisms...
Sperm migration in the female genital tract controls sperm selection and, therefore, reproductive success as male gametes are conditioned for fertilization while their number is dramatically reduced. Mechanisms underlying mostly unknown, since vivo investigations unfeasible ethical or practical reasons. By presenting a spatio-temporal model of mammalian combined with agent-based description motion and interaction well parameterizing it bovine data, we offer an alternative possibility...
The aim of the BW-eLabs architecture (networked virtual and remote labs in Baden-Wuumlrttemberg) is expansion access to heterogeneous experimental resources (remote virtual) for sustainable indexing use raw data experiments research education purposes. creation efficient possibilities external local surroundings as well a guarantee transparency reproducibility form central request. A substantial characteristic that corresponding documents are examined along their entire life cycle embedded...
This paper reviews the most encouraging process options for improving backend-of-line reliability performance in advanced technology nodes. Metal capping yields best electromigration performance; however, this is challenging with respect to integration and may also suffer from significantly decreasing grain sizes trench bottoms future technologies. Furthermore, time-dependent dielectric breakdown has be carefully evaluated. Alloying or silicidation techniques are less implement but can...
This paper compares the most encouraging process options for improving electromigration performance in advanced technology nodes. Metal capping yields best performance; however, this is challenging with respect to integration and may also suffer from significantly decreasing grain sizes trench bottoms future technologies. Alloying or silicidation techniques are less implement but can result unacceptably high resistance increases. We analyze respective results each option compare on 45, 32,...
Data tables in the form of spreadsheets or delimited text files are most utilised data format Systems Biology. However, they often not sufficiently structured and lack clear naming conventions that would be required for modelling. We propose SBtab as an attempt to establish easy-to-use table is both flexible clearly structured. It comprises defined types different kinds data; syntax rules usage names, shortnames, database identifiers used annotation; standardised formulae reaction...
This paper compares the most encouraging process options for improving electromigration performance in advanced technology nodes. Metal capping yields best performance; however, this is challenging with respect to integration and may also suffer from significantly decreasing grain sizes trench bottoms future technologies. Alloying or silicidation techniques are less implement but can result unacceptably high resistance increases. We analyze respective results each option compare on 45, 32,...
While dual damascene integration for current technologies is often cited its challenges in regard to patterning and demands on lithography hardand software. Metallization features with aspect ratios the range of 4:1 as well line widths 40nm shrinking thought be manageable established technologies. Void free fill lines vias mandatory yet reliability resistance gaining importance from one technology node next. Methods enhance are abound however which solutions extendible future nodes depends a...
Sperm migration in the female genital tract controls sperm selection and, therefore, reproductive success as male gametes are conditioned for fertilization while their number is dramatically reduced. Mechanisms underlying mostly unknown, since vivo investigations unfeasible ethical or practical reasons. By presenting a spatio-temporal model of mammalian combined with agent-based description motion and interaction well parameterizing it bovine data, we offer an alternative possibility...