A5032858129- Genetic diversity and population structure
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Lysosomal Storage Disorders Research
- Ecology and Vegetation Dynamics Studies
- Nuclear Structure and Function
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- Cellular transport and secretion
- RNA Research and Splicing
- Sunflower and Safflower Cultivation
- Genetic Mapping and Diversity in Plants and Animals
- DNA Repair Mechanisms
- Avian ecology and behavior
- RNA regulation and disease
- Telomeres, Telomerase, and Senescence
- Lipid metabolism and biosynthesis
- Polar Research and Ecology
- Genomics and Phylogenetic Studies
- Climate change and permafrost
- Neuroscience and Neural Engineering
- Plant and animal studies
- Identification and Quantification in Food
- Retinal Development and Disorders
- Soil Carbon and Nitrogen Dynamics
University of Colorado Boulder
2020-2023
Denver Botanic Gardens
2022-2023
Institute of Arctic and Alpine Research
2017
Salk Institute for Biological Studies
2011-2016
Universidad Católica San Antonio de Murcia
2015
University of Victoria
2010
Heterochromatin in aging stem cells Analysis of human syndromes, such as Werner syndrome (WS), may lead to greater understanding both premature and normal aging. Zhang et al. generated isogenic WS-specific embryonic cell lines (see the Perspective by Brunauer Kennedy). WS-mesenchymal displayed features characteristic aging, including heterochromatin disorganization. WRN protein thus functions maintenance heterochromatin, alterations represent a driving force Science , this issue p. 1160 ;...
Patterns of soil bacterial richness using operational taxonomic units (OTUs) and abundance groups (phylum or class) were studied in relation to plant characteristics the alpine at Niwot Ridge, Colorado, U.S.A. The study used a landscape gradient snow fence addition plots amended with nitrogen (N). Bacterial was not correlated total carbon (C) N, but showed strong positive correlations pH corresponding metallic cation concentrations. negative correlation (r = −0.86) acidity declined 30% over...
Abstract Conspecific populations living in adjacent but contrasting microenvironments represent excellent systems for studying natural selection. These are valuable because gene flow is expected to force genetic homogeneity except at loci experiencing divergent A history of reciprocal transplant and common garden studies such systems, a growing number genomic studies, have contributed understanding how selection operates populations. While can vary across different fitness components life...
Gaucher disease is an autosomal recessive disorder resulting from deficient activity of the lysosomal enzyme glucocerebrosidase (GBA, E.C.3.2.1.45). Three clinical forms have been described: type 1, nonneuronopathic; 2, acute neuronopathic; and 3, subacute neuronopathic (OMIM 230800, 230900, 231000). Over past decade, recognition a distinct, perinatal lethal form (PLGD) has led researchers clinicians to evaluate in differential diagnosis congenital ichthyosis nonimmune hydrops fetalis. To...
Hirundo is the most species-rich genus of passerine swallow family (Hirundinidae) and has a cosmopolitan distribution. Here we report complete, annotated mitochondrial genomes for 25 individuals from 10 14 extant species; these include representatives four subspecies barn swallow, H. rustica. Mitogenomes were conserved in size, ranging 18,500 to 18,700 base pairs. They all contained 13 protein-coding regions, 22 tRNAs, control region, large small ribosomal subunits. Phylogenetic analysis...
Abstract Conspecific populations living in adjacent, but contrasting, microenvironments represent excellent systems for studying natural selection. These are valuable because gene flow maintains genetic homogeneity except at loci experiencing strong, divergent A history of reciprocal transplant and common garden studies such systems, a growing number genomic studies, have contributed to understanding how selection operates populations. While can vary across different fitness components life...
ABSTRACT Regulation of gene expression is a critical link between genotype and phenotype explaining substantial heritable variation within species. However, we are only beginning to understand the ways that specific regulatory mechanisms contribute adaptive divergence populations. In plants, post-transcriptional mechanism alternative splicing (AS) plays an important role in both development abiotic stress response, making it compelling potential target natural selection. AS allows organisms...
Restoring native plant populations is an essential component of conserving biodiversity, ecological function, and ecosystem services. Restoration using local, ecotypic source materials largely acknowledged as best practice; however, local are not always available or adapted to current future site conditions. A major challenge in restoration comes from increasingly variable unpredictable environmental conditions that impose selective pressures threaten success. Understanding how conserve...