A5000069519- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Telomeres, Telomerase, and Senescence
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Mechanisms of cancer metastasis
- Immune cells in cancer
- BRCA gene mutations in cancer
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Ubiquitin and proteasome pathways
- interferon and immune responses
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
Washington University in St. Louis
2023-2024
Instituto Nacional do Câncer
2010-2019
The nuclear factor of activated T cells (NFAT) family transcription factors is expressed in a wide range cell types and regulates genes involved cycle, differentiation, apoptosis. NFAT proteins share two well-conserved regions, the regulatory domain DNA binding domain. N- C-terminal ends are transactivation sites show less sequence similarity, whereas their molecular functions remain poorly understood. Here, we identified transcriptional repressor, interferon 2 protein (IRF-2BP2), which...
Metastatic breast cancer is an intractable disease that responds poorly to immunotherapy. We show p38MAPKα inhibition (p38i) limits tumor growth by reprogramming the metastatic microenvironment in a CD4+ T cell-, IFNγ-, and macrophage-dependent manner. To identify targets further increased p38i efficacy, we utilized stromal labeling approach single-cell RNA sequencing. Thus, combined OX40 agonist synergistically reduced overall survival. Intriguingly, patients with signature had better...
Exposure to ionizing radiation greatly increases the risk of developing papillary thyroid carcinoma (PTC), especially during childhood, mainly due gradual inactivation DNA repair genes and damages. Recent molecular characterization PTC revealed methylation deregulation several promoters genes. Thus, epigenetic silencing might be a plausible mechanism for activity loss tumor suppressor in radiation-induced tumors. Herein, we investigated impact on global CpG islands within promoter regions...
<p>Contains supplemental figures and legends</p>
<p>Contains supplemental figures and legends</p>
<div>Abstract<p>Metastatic breast cancer is an intractable disease that responds poorly to immunotherapy. We show p38MAPKα inhibition (p38i) limits tumor growth by reprogramming the metastatic microenvironment in a CD4<sup>+</sup> T cell-, IFNγ-, and macrophage-dependent manner. To identify targets further increased p38i efficacy, we utilized stromal labeling approach single-cell RNA sequencing. Thus, combined OX40 agonist synergistically reduced overall survival....
<div>Abstract<p>Metastatic breast cancer is an intractable disease that responds poorly to immunotherapy. We show p38MAPKα inhibition (p38i) limits tumor growth by reprogramming the metastatic microenvironment in a CD4<sup>+</sup> T cell-, IFNγ-, and macrophage-dependent manner. To identify targets further increased p38i efficacy, we utilized stromal labeling approach single-cell RNA sequencing. Thus, combined OX40 agonist synergistically reduced overall survival....
<p>Contains supplemental figures and legends</p>
<p>Contains supplemental figures and legends</p>
<div>Abstract<p>Metastatic breast cancer is an intractable disease that responds poorly to immunotherapy. We show p38MAPKa inhibition (p38i) limits tumor growth by reprograming the metastatic microenvironment in a CD4+ T cell, IFNy, and macrophage dependent manner. To identify targets further increased p38i efficacy, we utilized stromal labeling approach single cell RNA sequencing. Thus, combined OX40 agonist synergistically reduced overall survival. Intriguingly, patients with...
<p>Contains supplemental figures and legends</p>
<p>Contains supplemental figures and legends</p>
NFAT family of transcription factors encodes 5 members and is present in a wide range cell types, regulating genes involved proliferation, angiogenesis, cycle progression apoptosis. has two well conserved regions: the regulatory domain DNA binding domain. N C‐terminal ends are transactivation sites show less sequence similarity. To understand molecular mechanisms related to functions we performed yeast hybrid screening using NFAT1 end as bait. We identified that interacts with IRF2BP2...
Abstract IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) protein is a gene expression regulator, acting as transcriptional cofactor. acts in different cellular process including DNA damage repair, apoptosis, and immune response. Even though few targets are known, there several putative IRF2BP2-regulated genes. Novel evidence suggests that plays central functions regulation. Recently, our group characterized the an NFAT1 repressor. To further understand role functions, this work...