A5030888510- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Biological Activity of Diterpenoids and Biflavonoids
- Essential Oils and Antimicrobial Activity
- Pomegranate: compositions and health benefits
- Plant biochemistry and biosynthesis
- Biopolymer Synthesis and Applications
- Photosynthetic Processes and Mechanisms
- Antioxidant Activity and Oxidative Stress
- Analytical Chemistry and Chromatography
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Ginseng Biological Effects and Applications
- Phytochemistry and Bioactivity Studies
- Natural product bioactivities and synthesis
- Kruppel-like factors research
- Phytochemistry and Biological Activities
- Tannin, Tannase and Anticancer Activities
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Pineapple and bromelain studies
- Protein purification and stability
Yazd University
2018-2025
University of Science and Arts of Oklahoma
2017-2024
Kharazmi University
2017
Abstract Extraction from the herbs was performed using Soxhlet method. Various formula synthesized for niosomes containing extracts through thin film synthesis technique, and most efficient formulation selected. Afterwards, physicochemical properties of niosomes, including size, polydispersity index (PDI), zeta potential, morphology, encapsulation efficacy (EE%), extract release rate, non-interactive action between antibacterial cellular uptake were assessed. Finally, toxicity level to...
Acute myeloid leukemia (AML) frequently relapses after initial treatment, though it is possible that drug resistance occurs. Hence, seems necessary to develop novel therapies such as gene therapy specifically via miRNA transfection. MicroRNA-101 has been considered a tumor suppressor in different types of cancer. It demonstrated exogenous miR-101 transfection associated with decreased viability AML this paper. Besides, the increase pro-apoptotic protein BIM expression both mRNA and level...
Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used study to prepare the optimized formulation niosomes containing extract, and evaluate its cytotoxicity. Methods & Materials Initially, extract (N. persica) prepared. Then, nano-niosomal system, designed synthesized using cholesterol Span-60. physicochemical properties system were evaluated by FTIR...
Abstract The RAS/MAP kinase pathway, pivotal in cancer development, intertwines with microRNAs (miRNAs), shaping CRC's dynamic cellular landscape. This study utilizes a systems biology approach, employing advanced bioinformatics tools to unravel miRNA-mediated regulatory networks CRC. Investigating miRNA dysregulation, identifying hub genes, and exploring interplay between signaling pathways aim provide nuanced insights into molecular Protein-protein network analysis uncovers the...
Evaluation of the Effect Niosomal Nano-Carriers Containing Rosemary(Rosemary officinalis) Essential oil on Survival KG-1 Cell Line Acute Myeloid Leukemia
Introduction: In recent years, the treatment strategy for infectious and autoimmune diseases has significantly changed. Up to now, cancer been conducted on basis of clinical pathological methods. The most common treatments is limited chemotherapy, radiation therapy surgery. However, still not optimal. Common challenges certain disease, e.g. cancer, are: systematic non-specific distribution drug agents, intolerable toxicity, insufficient concentration at site resistance. development...
Introduction: The use of nanoparticles containing antioxidant and cytotoxic plant compounds can have a special place in the treatment melanoma. aim this study was to evaluate effects pineapple fruit extract on skin cancer.
 Methods: In present experimental study, liposomal vesicles were prepared using cholesterol, soy phosphatidylcholine, polyethylene glycol, loaded liposomes. Physicochemical characteristics evaluated zeta sizer, FTIR AFM. Finally, toxicity different concentrations...
Introduction: Breast cancer is the most common among women and its treatment associated with many side effects. Herbal medicine has fewer effects than chemical drugs, so they are especially important in of diseases. Rosemary plant anti-cancer due to antioxidant properties. The aim this study was evaluate effect essential oil on BIM gene expression MCF-7 cell line.
 Methods: In experimental study, cellular toxicity rosemary oil, cells were exposed different concentrations for 24, 48 72...