A5075153045- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Insect Pest Control Strategies
- Bioactive Compounds and Antitumor Agents
- Hibiscus Plant Research Studies
- Mycobacterium research and diagnosis
- Traditional and Medicinal Uses of Annonaceae
- Phytochemicals and Medicinal Plants
- Phytochemistry and Biological Activities
- Malaria Research and Control
- Phytochemistry and Bioactivity Studies
- Plant biochemistry and biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactive Compounds
- Natural Compounds in Disease Treatment
- Plant-Derived Bioactive Compounds
- Moringa oleifera research and applications
- Natural Antidiabetic Agents Studies
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Bioactive natural compounds
- Food Quality and Safety Studies
- Natural Compound Pharmacology Studies
- Analytical Chemistry and Chromatography
Muhimbili University of Health and Allied Sciences
2006-2024
Sokoine University of Agriculture
2022
University of Copenhagen
2022
Nelson Mandela African Institution of Science and Technology
2022
Forestry Research Institute of Nigeria
2021
University of Mississippi
2006-2014
University of Nairobi
2010-2012
University of Botswana
2006
University of Antwerp
2006
Jomo Kenyatta University of Agriculture and Technology
2004
This study examined the chemical composition of essential oil from leaves Eucalyptus maculata and globulus found in Tanzania. The oils other species viz. E. saligna, citriodora camaldulensis has been described, but due to low abundance these plants grown different parts Tanzania are unknown. was extracted by steam distillation analyzed for various compositions using GC–MS. major identified compounds leaf were Eucalyptol (54.29%), p-cymene (10.10%), α-pinene (7.78%), β-myrcene γ-terpinene...
A new biflavanoid, ent-naringeninyl-(I-3α,II-8)-4'-O-methylnaringenin (6), along with five known xanthones and two biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration 6 established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC50 6.7 μM). Antitrypanosomal 0.87 μM) observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). dimeric xanthone garcilivin (4) a higher...
Malaria is an old life-threatening parasitic disease that still affecting many people, mainly children living in sub-Saharan Africa. Availability of effective antimalarial drugs played a significant role the treatment and control malaria. However, recent information on emergence P. falciparum parasites resistant to one artemisinin-based combination therapies suggests need for discovery new drug molecules. Therefore, this study aimed evaluate antiplasmodial activity extracts, fractions...
Chromatographic separation of the roots a Kenyan medicinal plant, Clerodendrum eriophyllum, led to isolation ten abietane diterpenoids (1-10), one which (1) was isolated for first time from natural source. Using spectroscopic data, structure 1 determined be 12-hydroxy-8,12-abietadiene-3,11,14-trione. Circular dichroism (CD) spectra showed that stereochemistry compounds 1, 3, and 6-8 belongs normal series diterpenes, confirmed absolute compounds. Compounds 1-10 were evaluated their in vitro...
Phytochemical investigation of the ethyl acetate-soluble fraction stem bark extract an African medicinal plant Terminalia brownii led to isolation a new oleanane-type triterpenoid, along with seven known triterpenoids, ellagic acid derivatives, and 3-O-β-D-glucopyranosyl-β-sitosterol. The compound was identified using spectroscopic methods, notably 1D- 2D NMR, as 3β,24-O-ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid. isolated compounds were evaluated for their antimicrobial...
Abstract Background The emergence of resistance to artemisinin-based combination therapy necessitates the search for new, more potent antiplasmodial compounds, including herbal remedies. whole extract Maytenus senegalensis has been scientifically investigated potential biological activities both in vitro and vivo, demonstrating strong antimalarial activity. However, there is a lack data on electrocardiographic effects M. humans, which crucial aspect investigation malaria treatment. Assessing...
Background. Inadequate specialized cancer hospitals and high costs are contributing factors that delay patients from accessing health care services in Tanzania. Consequently, majority of first seen by Traditional Health Practitioners (THPs) before they access services. This study presents ethnomedical information preliminary evaluation 25 plant species claimed THPs Mkuranga Same districts Tanzania on use for treatment cancer. Literature search laboratory investigation results presented to...
The 1:1 MeOH/CH2Cl2 extract of aerial parts Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7µg/ml) and resistant W2 15.0µg/ml) strains P. falciparum. Seventeen secondary metabolites were isolated evaluated for their in-vitro antiplasmodial, antileishmanial anticancer activities revealing on four carvotacetone derivatives 1-4; with antiplasmodial IC50 3.4, 0.6, 0.8, 1.4µg/ml respectively falciparum; 2.8, 0.7, 0.9,...
Aphloia theiformis is used in Makete district, Tanzania, and other areas by HIV AIDS patients as a weight loss remedy for treatment of tuberculosis. However, there no literature information on its antimycobacterial activity. To evaluate activity A. root ethanolic extract isolated compounds. The broth microdilution method was to test the crude against different non-pathogenic mycobacteria. Bioautography identify active constituents. Isolation compounds carried out using bioassay-guided...
Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases Africa, there a lack safety data regarding its use. Therefore, study aimed asselss tolerability antimalarial herbal remedy M. senegalensis. Material Methods: The design was an open-label, single-arm, dose-escalation. Twelve eligible male healthy Tanzanians aged 18 45 years were enrolled four dose groups. Volunteers’...
Label from glucose–U–14C and sucrose–U–14C was incorporated in O.14 % yield into leaf sesquiterpenes by isolated discs of Pogostemon cablin Patchouli'). The were shown to be a state rapid metabolic flux. There negligible incorporation leucine–U–14C, acetate–2–14CNaHCO3–14C andMVA–lactone–2–14C. It is concluded that the use leaf–discs simple reproducible system for study essential oil biosynthesis.
A method of preparation rotors with a reversed phase (RP) solid silica gel sorbent layer has been developed for centrifugal preparative chromatography (CPC), also known as rotational planar (RPC). The consist binder free RP SiO2 layers different thicknesses packed between two supported circular glass discs and can be used in any appropriate device chromatography, like Chromatotron CycloGraph. Polar /or semi-polar compounds close R(f) values, well extracts column fractions were separated...
The available tuberculosis (TB) therapies are taken for long time with complex regimens associated adverse effects and drug-drug interactions. emergence of multidrug resistant (MDR) extensively drug (XDR) strains Mycobacterium HIV co-infections necessitates the need continued search new effective anti-TB alternative leads different mechanisms action safety profile. aim this study was to isolate characterize antimycobacterial compounds from Hymenodictyon floribundum (Hochst. & Steud.)...
In this study we investigated the effect of exogenous ethylene treatment on production, 1-aminocyclopropane-1-carboxylate (ACC) oxidase activity and expression an ACC (PP-ACO1) gene previously cloned (Mathooko et al., 2001) in peach (Prunus persica L.) fruit. We also mode action CO2 and 1-methycyclopropene (1-MCP) regulation biosynthesis during fruit ripening. Fruits were treated with various concentrations (0.1, 1, 10, 100, 500, 1000 ppm) 1-MCP presence or absence 500 ppm...
Phytochemical analysis of twigs and roots Erythrina abyssinica, a traditionally used medicinal plant, gave new radical scavenging flavanone, 7,3′,4′-trihydroxy-5′-prenylflavanone (abyssinone VII; 1), along with twenty-one known compounds, whose antimicrobial activities were also assessed.
The use of plants as sources drug agents is attributed by factors among which are the easy accessibility to plants, less toxicity and little or no resistance. An improvement in both traditional medicine discovery field necessitates investigation pure compounds any plant with medicinal value. Synadenium glaucescens Pax family Euphorbiaceae Tanzania proven contain bioactive against microbial infections. Analysis ethanolic methanolic extracts root stem barks respectively aided isolated six...
Commiphora swynnertonii (Burtt) is a medicinal plant with diverse traditional uses in Tanzania. However, there limited information on isolation and cytotoxicity properties of bioactive compounds responsible for its pharmacological activities. Hence, this study attempted to isolate assess toxicity from leaves, stem barks whole root. Isolation was done by column chromatography method. There structures were deduced the aid NMR GC-MS data comparison spectral available literatures. Cytotoxicity...
Terminalia brownii is an African medicinal plant used to treat parasitic and microbial infections. A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1), along with seven known triterpenoids ellagic derivatives. The compounds were evaluated for their antiplasmodial, antileishmanial antimicrobial activities giving most...
Two new arabinofuranosidetridecanol, namely 1,2-tridecanediol-1-O-α-L-5'-acetylarabinofuranoside (1) and 1,2-tridecanediol-1-O-α-L-arabinofuranoside (2) together with known compound, 1,2-tridecanediol (3) were isolated from Commiphora merkeri exudate. Compound 1 showed larvicidal activity against Ae. aegypti (LC50 = 40.66 µg/mL), An. gambiae 22.86 µg/mL) Cx. quinquefasciatus 15.88 µg/mL). Also, 2 had 33.79 31.99 17.70 There no significant difference of larvae mortalities (≥ 95%) among the...
Commiphora swynnertonii (Burtt) is traditionally used for medicinal purposes both in humans and animals Tanzania. Previously, its leaves extract has been demonstrated antibacterial activity. However, there limited information on identification of pure compounds responsible observed Therefore, this study was conducted to isolate evaluate activity isolated from extract. Colum chromatographic separation dichloromethane afforded the isolation two sterols namely, Cholest-7-en-3β-ol (1)...