Abstract Background Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. Aim We aimed at exploring potential link between inflammation AA patients through measuring 8‐hydroxy deoxyguanosine (8‐OHdG), high mobility group box 1 protein (HMGB1), one inflammatory mediators, C‐reactive (CRP). Methods A total 79 subjects (49 addition to 30 apparently healthy control...

The Shiga toxin-producing Escherichia coli (STEC) represented a great risk to public health. In this study, 60 STEC strains recovered from broiler and duck fecal samples, cow's milk, cattle beef, human urine, ear discharge were screened for 12 virulence genes, phenotypic genotypic antimicrobial resistance, multiple-locus variable-number tandem-repeat analysis (MLVA).The majority of harbored toxin 1 (stx1) stx1d, stx2 stx2e, ehxA while minority stx2c subtype eaeA. We identified 10 stx gene...

Background: Objective to explore the link between disease activity and IL-23R genetic variation (rs11805303) in a cohort of Egyptian individuals at risk for rheumatoid arthritis. Patient Methods: One hundred participants, ranging age from thirty sixty, 56 whom had RA 44 were apparently healthy matched sex with patients, documented methodology. All participants genotyped using PCR/RFLP variation. Kruskal-Wallis Mann-Whitney tests, as well chi-square (χ2), Monte Carlo logistic regression, used...

Alopecia areata (AA) is the second most frequent nonscarring alopecia after androgenetic alopecia; trigger factor induces changes in growth plate of hair bulb and leads to premature termination anagen phase. Epidermal (EGF) can be key molecule that participates initiation suppression normal cycle. The role EGF pathogenesis AA still uncertain.This aim estimate serum level patients with trying detect its correlate it disease severity.This case-control study included 60 clinically diagnosed...

Abstract Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that still used for treatment tonic-clonic seizures in children. Long-term use AEDs induces potential toxic effects may remain undetermined a long time. Earlier studies have revealed wide spectrum hematological toxicities associated with CBZ. This study was conducted to unveil carbamazepine as an monotherapy on and immunological parameters group Egyptian pediatric patients using it different durations. Fifty...

The aim of the study is to investigate relation neonatal and maternal vitamin D late-onset sepsis (LOS).

Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by joint destruction, chronic inflammation, and autoantibody production. IL-21 plays an essential role in the immunopathology of RA. The aim study: was to investigate association between plasma interleukin-21 gene polymorphism susceptibility rheumatoid Egyptian patients find out its relation activity. Methods: This case control study conducted on 100 subjects; divided into two groups:Group(I):70 RA...

Background: In A high rate of death and long-term morbidity are still linked with early-life sepsis caused by bacterial, viral, or fungal infections, despite advancements in newborn care maternal antibiotic prophylaxis for GBS. Early onset neonatal (EOS) is a major contributor to sickness the first seventy-two hours baby's life. cases septicemia, C-reactive protein (CRP) test seems be useful. Progranulin (PGRN) an autocrine growth factor 593 amino acids that regulates crucial TNF/TNFR...

Background Insulin resistance has a significant relationship with lot of chronic diseases. This is an alarm for the future high prevalence many Due to lack sufficient data surrounding clinical manifestations insulin among Saudi population, study aims fill this gap by assessing dermatological, cognitive, daytime sleep, and craving changes in which are markers resistance. Methods A cross-sectional was carried out known be associated convenient nonprobability sample 272 female medical students...

Angiosarcoma (AS) is a rare and aggressive soft tissue sarcoma originating from endothelial cells, with cutaneous manifestations often seen in the head neck region. Despite its rarity, AS poses significant diagnostic challenges due to variable presentation ability mimic other dermatological conditions. We report case of an 87-year-old female that presented 4-month history asymptomatic nodule on her neck, which rapidly progressed into indurated plaque spreading face, chest, scalp. Initially...

The aim of this study was to evaluate the role serum human epididymis protein 4 (HE4) as a non-invasive biomarker for diagnosis liver fibrosis in children with chronic diseases (CLD). This case-control conducted at Benha University Hospital, Egypt, involving 60 CLD and healthy control group. HE4 levels were measured by ELISA compared biopsy results. group had significant higher (median: 110.7, IQR: 96.7–120.4 pmol/L) (median 42.07, 41.67–43.05 pmol/L), p < .001. increased significantly...

Background: Interferon lambda 4(FNL -4 rs368234815) predicts the HCV clearance and assess predictive value of IFNL4 polymorphism in treatment chronic Egyptian patients its allele frequency compared with controls .Direct-acting antivirals (DAAs) has seen a significant increase hepatitis C virus (HCV) clearing their infection. The INFL rs368234815 was powerful predictor sustained virological response (SVR). Methods: Evaluation for performed by restriction fragment length analysis (PCR- RFLP)...

Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, data only cover a few ethnicities.The present work intended investigate association APOE polymorphism and serum lipids with susceptibility SFIs among group Egyptian patients.Standard laboratory methods were used estimate lipid profile, polymerase chain reaction-restriction fragment length was detect in deoxyribonucleic acid extracted from 150 SFI patients an equal number...

skin structure infections, hospital-acquired pneumonia (HAP), and catheter-associated urinary tract infections (CAUTI).It was estimated that at least 7.5% of healthcare associated were caused by P. aeruginosa, including 16.6% VAP, 11.3% CAUTI, 5.5% SSI, 3.8% CLABSI leading to high rates morbidity

Background: In spite of advancements in newborn care and maternal antibiotic prophylaxis for GBS, early-life sepsis caused by bacterial, viral, or fungal infections is still linked with significant mortality long-term morbidity.In the first 72 hours life, early onset neonatal (EOS) a considerable source disease death.The Creactive protein (CRP) test seems to be useful baby septicemia.IL-27 heterodimeric cytokine generated antigen-presenting cells response microbial products inflammatory...

Alopecia areata is a common cause of non-scarring alopecia that occurs in patchy, confluent or diffuse pattern.The EGF can promote growth the ORS compartment mink hair follicles vitro, and enhance proliferation migration cells via activation Wnt/β-catenin signaling pathway.Evaluation serum levels patients with areata.Serum concentrations were measured 60 consecutive comparison 25 controls using enzyme-linked immunosorbent assay (ELISA).Serum found to be higher than healthy...

Background and Aim: This prospective observational study was designed aiming at evaluation of the possible effect phototherapy on pro-oxidant/antioxidant balance (PAB) in newborns with jaundice.Patients Methods: included forty admitted to NICU Benha University Hospitals.The patients were full term, weighting > 2500 gm, aged between 2 14 days, idiopathic unconjugated hyperbilirubinemia (bilirubin levels 15 mg/dl) treated phototherapy.All studied subjected medical history taking, complete...

Background: Asthma is a complex, multifactorial, immune-mediated condition with number of molecular immunopathological mechanisms underlying airway inflammation, hyper reactivity, and bronchial remodeling.MicroRNAs are important regulators in the pathogenesis progression chronic respiratory diseases, including asthma.Objective: The aim study to investigate level expression serum miR-1165-3p allergic asthma its correlation IgE levels.Subjects Methods: A case-control was conducted on 30 cases...

The development of alopecia areata is suggested to be influenced by intestinal permeability and gut dysbiosis. Claudin-3, an essential component tight junctions which may act as indicator barrier integrity.The study's objective was evaluate the plasma concentration level Claudin-3 in patients its relationship severity condition.In this case-control study, 50 30 healthy age sex controls were involved. An enzyme-linked immunosorbent assay used determine claudin-3 blood.Patients with had...

Background: Beta-thalassemia major ( -TM) is a genetic disorder characterized by impaired hemoglobin synthesis, leading to hemolytic anemia and associated complications.This study aimed assess the diagnostic value of serum osteoprotegerin (OPG) as an early biomarker for osteoporosis in B-TM children. Patients Methods:A cross-sectional was conducted at Pediatric Department Benha University Hospital from January 2022 December 2022.The included 64 children aged 2 18 years, divided into two...