Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial infections, has been associated with drug-induced liver damage. Quercetin (QR), naturally occurring flavonoid pleiotropic biological activities, poor water solubility and low bioavailability. The objective this work was to produce more bioavailable formulation QR (liposomes) determine effect its intraperitoneal pretreatment on amelioration Co-Amox-induced damage in male rats. Four groups rats were...

Hyaluronic acid (HA) is a versatile polysaccharide with broad range of biological, pharmacological, and therapeutic applications due to its anti‐inflammatory properties, low immunogenicity, natural breakdown, compatibility live tissue, capacity promote cell growth specialization. However, the potential negative effects HA on aquatic ecosystems, especially fish, have not been fully investigated. This study examines for first time physiological, immunological, histological in African catfish,...

Imidacloprid (IMI) is a widely used insecticide known for its high selectivity toward insects. Ellagic acid (EA) plant-derived polyphenolic compound recognized therapeutic potential and favorable safety profile in the treatment of various diseases. This study aimed to evaluate effects EA, formulated as novasomes (NOV), against IMI-induced thyroid dysfunction investigate underlying mechanisms. Rats were divided into four equal groups: control, EA-NOV, IMI, IMI + EA-NOV. Thyroid function was...

There have been concerns about the potential health risks posed by microplastics (MP). The detection of MP in a variety food products revealed that humans are ingesting MP. Nevertheless, there is paucity data their impacts, as well uptake, on intestinal barrier integrity. This study examined toxic effects oral administration two doses polyethylene (PE-MP) (3.75 or 15 mg/kg/day for 5 weeks; mean particle size: 4.0-6.0 µm) integrity rats. Moreover, effect melatonin treatment with exposure was...

There are various substances that can disrupt the homeostatic mechanisms of body, defined as endocrine-disrupting chemicals (EDCs). The persistent nature microplastics (MPs) is a cause for concern due to their ability accumulate in food chains and widespread use, making toxic effects particularly alarming. potential MPs disrupting endocrine system was observed multiple tissues. Moreover, adrenal gland known be extremely sensitive EDCs, while with effect on has not previously been studied....

Abstract Since its identification in the vitreous humour of eye and laboratory biosynthesis, hyaluronic acid (HA) has been a vital component several pharmaceutical, nutritional, medicinal, cosmetic uses. However, little is known about potential toxicological impacts on aquatic inhabitants. Herein, we investigated hematological response Clarias gariepinus to nominal doses HA. To achieve this objective, 72 adult fish were randomly evenly distributed into four groups: control, low-dose (0.5...

Background: Acute children poisoning is considered a serious issue worldwide, and common cause of morbidity mortality. It preventable burden on emergency departments healthcare facilities. Thus, surveillance epidemiology patterns acute in each country beneficial to define the scope problem its management regarding prevention treatment. The aim this work study Banha control center, University, Egypt. Methods: One year prospective cross-sectional pattern equal or less than 18 years old, who...

Abstract Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that still used for treatment tonic-clonic seizures in children. Long-term use AEDs induces potential toxic effects may remain undetermined a long time. Earlier studies have revealed wide spectrum hematological toxicities associated with CBZ. This study was conducted to unveil carbamazepine as an monotherapy on and immunological parameters group Egyptian pediatric patients using it different durations. Fifty...

Imidacloprid (IMI) is a commonly used new-generation pesticide that has numerous harmful effects on non-targeted organisms, including animals. This study analysed both the adverse pancreas following oral consumption of imidacloprid neonicotinoids (45 mg/kg daily for 30 days) and potential protective lycopene (LYC) administration (10 mg/kg/day with IMI exposure in male Sprague-Dawley rats. The apoptotic, pyroptotic, inflammatory, oxidative stress, endoplasmic reticulum stress biomarkers were...

Abstract Concerns have been expressed about imidacloprid (IMI), one of the most often used pesticides, and its potential neurotoxicity to non‐target organisms. Chronic neuroinflammation is central pathology several neurodegenerative disorders. Hence, exploring molecular mechanism by which IMI would trigger particularly important. This study examined neurotoxic effects oral administration (45 mg/kg/day for 30 days) neuroprotective effect berberine (Ber) chloride loaded nano‐PEGylated...

Background: Ocular trauma is the leading cause of monocular blindness in children. This study aimed to identify and compare pediatric ocular injuries at two national university hospitals: Benha University Hospital (BUH) South Valley (SVUH) while evaluating predictive utility Trauma Score (OTS) for post-traumatic permanent visual infirmity. Design methods: multicenter observational enrolled children under 18 years BUH SVUH Ophthalmology Departments from May 31 December 31, 2022. Comprehensive...

Background: Lamotrigine (LTG) and levetiracetam (LEV) are widely increasingly prescribed second generation antiepileptic drugs for women with epilepsy during childbearing age. However, data pertaining to their congenital malformations lacking. Aim: This study aimed investigate compare the teratogenic effects of LTG LEV on normal adult female albino rats fetuses in order find out least one them. Materials methods: Ninety-six (64 virgin females 32 males) almost same range weight age were used....

Abstract Ochratoxin A (OTA) is a well-known mycotoxin that adversely affects different human cells. Inhalational exposure to OTA and subsequent pulmonary diseases have been previously reported, yet its potential carcinogenicity underlying molecular mechanisms not fully elucidated. This study aimed evaluate the OTA-induced cytotoxicity epigenetic changes in fetal lung fibroblast (WI-38) was assessed by MTT assay; RT-qPCR used determine expression of BAX , BCL-2 TP53 miR-155 while ELISA for...

Signal joint T cell receptor excision circles (sjTRECs) are a promising marker for age estimation and immunosenescence in different ethnic groups. Several limitations expected to overshadow their use as accurate markers prediction. The current study was conducted determine the influence of immunologic disorders, such autoimmune diseases COVID-19, on accuracy sjTRECs molecular among living Egyptians. Peripheral blood level measured by qPCR 90 patients, 58 COVID-19 85 healthy controls. mean...

Fibronectin and P-selectin are immunohistochemical markers of skin wounds vitality age estimation. This study aimed to assess compare between fibronectin as dating antemortem (AM) postmortem (PM) human wounds. was carried out on 140 cases that were classified into three main groups; Group I [90 received at the Emergency Department, Benha University Hospital, Egypt], sub-classified according wound age: AM1 (<30minutes; n = 30), AM2 (30-60 minutes; AM3 (60-90 30); II [40 cadavers Zenhum...

Background Medical malpractice suits represent a valuable source of information on medical errors.Therefore, greater understanding the claims may highlight their causes and thus help to prevent them.Aim: To evaluate problem study epidemiological medicolegal aspects reported cases at medico legal region Benha, Qalyubia governorate from (2010 2014).Methods: Retrospective analysis all claims, registered during period (from January 2010 December 2014) in .Cases were reviewed authority...

Chlorpyrifos (CPF);Green tea; Epigallocatechin-3-gallate (EGCG); Oxidative stress. . (CPF) can induce ovarian damage and reproductive dysfunctionthrough oxidative stress mechanisms.These be reversed by antioxidants such as (EGCG) in green tea.This study aimed to investigate the toxicity effects of CPF on rat ovaries effectiveness EGCG protect against these effects.Fifty adult female albino rats were randomly assigned five equal groups; negative positive control groups, EGCG-treated group,...

Di-ethylhexyl phthalate (DEHP) is a global environmental pollutant. Human exposure to DEHP occurs through sources. Community (food, air, water) as well medical settings' impose crucial effects on the human health. had been reported have cytotoxic, immunotoxic, genotoxic, and reproductive toxic properties. This work aims assess possible of adult albino rats' lungs evaluate protective N-acetylcysteine (NAC) using body weight relative lung parameters. Assessment DHEP toxicity measured by...

ABSTRACT Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV infections. It has been reported that NVP toxic effect on liver, kidney and male reproductive system. This study was designed to assess effects these tissues (liver, testis) its possible genotoxic mutagenic effects. Forty adult albino rats were divided into 4 groups (10 each): (A) negative control group, (B) positive group received 1ml/ day corn oil, (C) NVP1 treated 3.6mg (loading...