A5060336738- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
- Vitamin C and Antioxidants Research
- Regulation of Appetite and Obesity
- Pesticide Exposure and Toxicity
- Biochemical Analysis and Sensing Techniques
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Effects and risks of endocrine disrupting chemicals
- Cardiovascular Disease and Adiposity
- Intraocular Surgery and Lenses
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Sirtuins and Resveratrol in Medicine
- Peroxisome Proliferator-Activated Receptors
- High Altitude and Hypoxia
- Peptidase Inhibition and Analysis
- Heavy Metal Exposure and Toxicity
- Adipokines, Inflammation, and Metabolic Diseases
- vaccines and immunoinformatics approaches
- Infectious Encephalopathies and Encephalitis
- Cardiac Ischemia and Reperfusion
King Khalid University
2013-2024
Zagazig University
2018-2024
Ain Shams University
2023-2024
Association Marocaine Pour la Recherche Développement
2008-2009
This study compared the effect of low-fat diet (LFD) and high-fat rich in corn oil (HFD-CO) on left ventricular (LV) fibrosis rats examined their angiotensin II (ANG II), JAK/STAT, TGF-1β/smad3 pathways. As to LFD which didn't affect any measured parameters, HFD-CO-induced type 2 diabetes phenotype increased LV collagen synthesis. Mechanistically, it levels ROS, ANG II, ACE, IL-6, s-IL-6Rα, TGF-β1, Smad-3, activities JAK1/2 STAT1/3. AG490, a JAK2 inhibitor, partially ameliorated these while...
Food additives such as nitrates and nitrites, monosodium glutamate (MSG) used in the food industry increase risk of certain cancers inflict damage to vital organs. We sought determine whether antioxidant vitamin E can protect against liver injuries induced by a toxic dose MSG rat model MSG-induced acute injury. The group rats received daily (4 gm/kg) for 7 days, whereas protective groups were either 100 mg/kg plus or 300 days. Rats then sacrificed at day 8. Transmission light microscopy...
Replication Factor C Subunit 4 (RFC4), an oncogene implicated in many human cancers, has yet to be extensively studied cancer types determine its expression patterns and tumor tissue function. Various bioinformatics tools were used analyze RFC4 as a potential therapeutic target across cancers. We first examined levels several relationships with grade, stage, metastasis, patient survival. also RFC4’s genetic changes, epigenetic methylation, effect on microenvironment (TME) immune cell...
Abstract Background Newcastle Disease Virus (NDV) causes severe economic losses in the poultry industry worldwide. Hence, this study aimed to discover a novel bioactive antiviral agent for controlling NDV. Streptomyces misakiensis was isolated from Egyptian soil and its secondary metabolites were identified using infrared spectroscopy (IR), gas chromatography–mass spectrometry (GC–MS), nuclear magnetic resonance (NMR) spectroscopy. The inhibitory activity of metabolite against NDV examined....
Currently, doxorubicin (DOX) is one of the medications commonly used in chemotherapy to treat different types tumors.Nonetheless, despite being effective multiple tumors, yet its use limited owing cytotoxic effects, therapeutic DOX has been limited. This work aimed explore whether curcumin (CMN) can prevents DOX-induced cardiotoxicity rats. Four groups rats were created, with first functioning as a control, while second group received CMN. alone was administered third group, whereas CMN and...
Amiodarone (AMD) is one of the highly effective antiarrhythmic agents used for treating refractory arrhythmias. It well known to have long-term administration side effects such as nephrotoxicity. The possible ameliorative antioxidant grape seed extract; on extent tissue damage in AMD-induced nephrotoxicity has not been investigated before. Twenty-four albino rats were this study and divided into four groups (n = 6). 1st group served an untreated control group, under same laboratory...
Syphilis, a sexually transmitted infection, is deadly disease caused by Treponema pallidum. It Gram-negative spirochete that can infect nearly every organ of the human body. be both and perinatally. Since syphilis second most fatal after AIDS, an efficient vaccine candidate needed to establish long-term protection against infections T. This study used reverse-vaccinology-based immunoinformatic pathway subtractive proteomics find best antigenic proteins for multi-epitope production. Six...
Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear.To examine if confers cardio-protection during cardiac remodelling post-MI modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway.Rats were divided into control, sham, sham + ghrelin, myocardial infarction (MI), and MI groups. Ghrelin (100 µg/kg) was administered for 21 days, starting one-day post-MI.Ghrelin enhanced contractility activities of antioxidant enzymes, lowered serum levels enzyme markers...
The chance of survival rate and autophagy smooth muscle cells under calcium stress were drastically improved with a prolonged inclusion Lycopene in the media. results showed an viability from 41% to 69% reduction overall autophagic bodies 7% 3%, which was well agreement LC3II III mRNA levels. However, proliferation slow compared controls. fall major inflammatory marker TNF-α antioxidant enzyme GPx regarded as significant restoration markers cell survival. reactive oxygen species (ROS)...
Urinary tract infections (UTIs) are healthcare problems that commonly involve bacterial and, in some rare instances, fungal or viral infections. The irrational prescription and use of antibiotics UTI treatment have led to an increase antibiotic resistance. Urine samples (145) were collected from male female patients Lower Dir, Khyber Pakhtunkhwa (KP), Pakistan. Biochemical analyses carried out identify uropathogens. Molecular analysis for the identification 16S ribosomal RNA was performed...
We tested the hypothesis that swim exercise can protect articular cartilage from damages induced secondary to insulin-dependent diabetes mellitus in rats using scanning electron microscopy and monitor blood levels of oxidative antioxidative stress biomarkers are known be modulated osteoarthritis (OA). A profound damage was observed diabetic rats. Our findings also show protects knee joints by as well significantly inhibiting OA-induced upregulation thiobarbituric acid reactive substances...
The aim of this study was to assess L-carnitine’s effects on adult male rats’ lung damage brought by amiodarone, which is a potent antiarrhythmic with limited clinical efficacy due potentially life-threatening amiodarone-induced damage. Because the resemblance among structural abnormalities in lungs that follows amiodarone medication and pulmonary toxicity human beings, animal model may be an appropriate example for disease entity. Amiodarone produced twenty-four healthy albino rats (150–180...
A field visit was conducted in March 2002 to identify viruses infecting the faba bean (Vicia faba) crop four governorates (Fayoum, Beni Suef, El-Nobareia and Bihera) Egypt. total of 71 samples with symptoms viral infection (leaf rolling, yellowing mosaic) were collected. These tested at Virology Laboratory ICARDA, Syria, for seven using tissue-blot immunoassay procedure (Makkouk & Comeau, 1994). Specific rabbit polyclonal antisera used test Chickpea chlorotic dwarf virus (CpCDV, genus...
Amiodarone, a class III antiarrhythmic drug, has been found to be effective in the management of patients with life-threatening ventricular arrhythmias. The aim this study was test whether co administration vitamin-E amiodarone can reduce amiodarone-induced liver damage.Twelve male albino rats were divided into three groups (ml vegetable oil/day by oral gavages daily for 2 weeks and used as control group. second group received 5.4 mg amiodarone/100 gm rat dissolved oil weeks. In third group,...
Pioglitazone (Pio) and swimming exercise (SE) are insulin sensitisers. This investigation was suggested because of the significant side effects associated with Pio treatment in metabolic syndrome (MetS). study was, therefore, designed to investigate preventive role SE terms efficiency pathological changes MetS a rat model. Sixty male Sprague-Dawley rats were distributed equally among 6 groups: (i) control group (C), (ii) exercised (C+E), (iii) Pio-treated (C+Pio), (iv) MetS, (v) treated...