A5004476989- Synthesis and Reactions of Organic Compounds
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Organic Compounds
- Inorganic and Organometallic Chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Chemical Reactions and Mechanisms
- Synthesis of heterocyclic compounds
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Chemical Reaction Mechanisms
- Cyclopropane Reaction Mechanisms
- Multicomponent Synthesis of Heterocycles
- Asymmetric Synthesis and Catalysis
- Piperaceae Chemical and Biological Studies
- Neuroscience and Neuropharmacology Research
- Organic and Inorganic Chemical Reactions
- Quinazolinone synthesis and applications
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
Cairo University
1965-2025
Armed Forces College of Medicine
2024-2025
Karolinska Institutet
1993
National Research Centre
1965-1988
Max Planck Society
1978
The hitherto unknown 2-(2-nitroethenyl)aryl and 1-(2-nitroethenyl)naphthalen-2-yl N-arylcarbamates (2) (5) are readily obtained through the uncatalysed interaction of aryl isocyanates with corresponding 2-nitroethenyl phenols (1) (4). carbamates cyclize at ambient temperature under base catalysis to 3-aryl-4-nitromethyl-3,4-dihydro-2H-1,3-benzoxazin-2-ones (3) 2-aryl-1-nitromethyl-2,3-dihydro-1H-naphth[l,2-e][1,3]oxazin-3-ones (6). oxazinones cleaved by hot pyridine affording...
Food additives such as nitrates and nitrites, monosodium glutamate (MSG) used in the food industry increase risk of certain cancers inflict damage to vital organs. We sought determine whether antioxidant vitamin E can protect against liver injuries induced by a toxic dose MSG rat model MSG-induced acute injury. The group rats received daily (4 gm/kg) for 7 days, whereas protective groups were either 100 mg/kg plus or 300 days. Rats then sacrificed at day 8. Transmission light microscopy...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl and Thiocarbonyl Compounds. VII.1a A New Method for the Direct Synthesis of Ethylene SulfidesN. Latif I. FathyCite this: J. Org. Chem. 1962, 27, 5, 1633–1636Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 1962https://doi.org/10.1021/jo01052a035RIGHTS & PERMISSIONSArticle Views92Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article...
The link between oxidative stress (ROS), apoptosis (p53) and fibrosis (collagen) in type 2 diabetes mellitus (T2DM)-induced cardiac injury the presence absence of antidiabetic drug, metformin has not been investigated before.T2DM was induced rats by a combination high carbohydrate fat diets (HCFD) streptozotocin (50 mg/kg) injection. protection group started (200 treatment 14 days prior to induction continued on HCFD until being sacrificed at week 12.Diabetes significantly blood levels ROS...
Acute restraint stress (ARS) is an unavoidable situation and may be encountered in different clinical situations. The aim of the current study was to investigate effects ARS on hippocampus cerebellum, assess impact these behavior cognitive function, determine whether pretreatment with ceftriaxone would attenuate damages produced by cerebellum. Four groups male mice were included this study: control group, + group. Tail suspension test, Y-maze task, open field tests used depression, working...
Dispiro (xanthene-9,2′-thiirane-3′,9″-xanthene), dispiro(thioxanthene-9,2′-thiirane-3′,9″-thioxanthene), epithiobidiphenyleneethane, epithiotetraphenylethane, epithiotetra-p-anisylethane, and epithiotetra-p-tolylethane are directly synthesized by the base-catalyzed interaction of corresponding ketohydrazones, elemental sulfur, yellow mercuric oxide. The reaction mechanism is discussed. Epithiotetra-p-tolylethane also obtained uncatalyzed sulfur with diazoalkane.
Cardiovascular disease secondary to diabetes represents a significant challenge the health community. The advanced glycation end products (AGEs) play an important role in diabetes-mediated vascular injury. We tested whether metformin can suppress aortic AGEs production and protect against injuries (aortopathy) hypertension streptozotocin-induced type 2 mellitus (T2DM) animal model. T2DM was induced rats two weeks after being fed on high carbohydrate fat diet (HCFD), continued HCFD until...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl and Thiocarbonyl Compounds. V.1 Synthesis of Newer Unsaturated Nitriles, Carboxylic Acids, Esters Derived from Xanthene ThiaxantheneM. M. HAFEZ, N. LATIF, I. F. ZEIDCite this: J. Org. Chem. 1961, 26, 10, 3988–3991Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a081https://doi.org/10.1021/jo01068a081research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl and Thiocarbonyl Compounds. II.1 Reaction of Halogenated o-Quinones with Certain Hydrazones DiazocompoundsN. LATIF, I. FATHY, N. MISHRIKYCite this: J. Org. Chem. 1959, 24, 12, 1883–1885Publication Date (Print):December 1, 1959Publication History Published online1 May 2002Published inissue 1 December 1959https://pubs.acs.org/doi/10.1021/jo01094a013https://doi.org/10.1021/jo01094a013research-articleACS PublicationsRequest reuse...
Abstract The nature of the products uncatalysed reaction o ‐hydroxybenzaldehydes 1a‐d with ‐phenylenediamine in boiling ethanol is mainly dependent on molar ratio reactants and substituents at phenyl ring aldehyde. In contrast, m ‐ p ‐hydroxy analogues 1e‐g afford exclusively corresponding 1‐aralkyl‐2‐arylbenzimidazoles 6 , regardless these factors. However, low temperature, hydroxybenzaldehydes 1a‐g react diamine always giving monoanils ( 2 ) hydroxy position. aldehydes predominantly...
Background The potential inhibitory effects of captopril, the angiotensin-converting enzyme inhibitor, on thioacetamide (TAA)-induced hepatic mammalian target rapamycin (mTOR), liver injury enzymes, blood pressure, and biomarkers inflammation oxidative stress have not been investigated before.Materials methods Rats were either injected with TAA (200 mg/kg; twice a week for 8 weeks) before being sacrificed after 10 weeks (model group) or pretreated captopril (150 mg/kg) daily two prior to...
Abstract Using pulse radiolysis with conductivity detection and steady state γ‐radiolysis it is shown that in aqueous solution the reaction of OH radicals 2,3‐ 4‐monohalo (X = F, Cl, Br) anisoles leads to production hydrogen halides (HX). The G‐values for measured 10 μs after are large 2‐ 4‐haloanisoles ( G (HX) 0.5‐1.45) small 3‐haloanisoles 0.1‐0.3). These yields reflect amount addition ring positions substituted by X. differences these amounts an ortho‐para directing activity methoxy...
Abstract Tetrachloro‐ and tetrabromo‐o‐benzoquinone react with furfurylidene‐( 2a ) 5‐chlorofurfurylidene‐ ( 2b nitromethane in boiling benzene to give the dihydrofurobenzodioxin adducts 3a – d , respectively, through a D IELS ‐A LDER type of reaction. In contrast, under similar conditions, tetrachloro‐o‐benzoquinone reacts furfural 5‐chlorofurfural give, both cases, ether 10 without incorporation furyl residue into molecule. However, when reaction is light catalysed, polyhalohydroxyphenyl...
The benzoxanthene ethers Ia–IIb are obtained in good yields by the action of tetrachloro-and tetrabromo-o-benzoquiuone on 1,2- and 3,4-benzoxanthione, respectively. benzopyran analogues IIIa–IIIb interaction corresponding haloquinone coumarin hydrazone. latter, which is now readily hydrazine hydrate coumarin-2-thione, condenses with thioketones to give azines. IIIa IIIb cleaved malononitrile, cyanoacetic ester, hydrate, phenylhydrazine, benzoylhydrazine, yielding unsaturated nitriles (Va–Vb)...
9,9-(Tetrachloro-o-phenylenedioxy) xanthene (IIa) and its thio-analogue (IIb) are cleaved by hydrazines to give the corresponding hydrazones of xanthone thiaxanthone, respectively, together with tetrachlorocatechol. The unsaturated nitriles (Va), (Vb), (Vc) produced similarly action malononitrile cyanoacetic ester. Dixanthenyl ether itself reacts in a similar manner active hydrogen compounds 9-xanthyl derivatives. is prepared 9-diazothiaxanthene on tetrachloro-o-benzoquinone readily lithium...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl and Thiocarbonyl Compounds. VI.1 (a) Synthesis of Newer Fluorenylidene Cyclic Ethers from Tetrahalo-o-benzoquinones. (b) The Reductive Cleavage Methylenedioxy Compounds by Lithium Aluminum HydrideN. LATIF MISS N. MISHRIKYCite this: J. Org. Chem. 1962, 27, 3, 846–849Publication Date (Print):March 1, 1962Publication History Published online1 May 2002Published inissue 1 March...
Gastric ulcer is one of the most serious diseases.Nebivolol (Neb), a β1-blocker, exhibits vasodilator and antioxidative properties, simvastatin (Sim) antihyperlipidemic drug, anti-oxidative, anti-inflammatory properties promote endogenous nitric oxide (NO) production.The aim this study was to evaluate gastroprotective effects Neb Sim against cold restraint stress (CRS)-induced gastric in rats.Rats were restrained, maintained at 4°C for 3 hours.Animals divided into six groups; control group,...
Introduction: The high levels of angiotensin II (Ang II) can modify the vascular tone, enhance smooth muscle cells (VSMCs) proliferation and hypertrophy increase inflammatory cellular infiltration into vessel wall. old herbal nonpharmacological agent, Hibiscus (HS) sabdariffa L has multiple cardioprotective impacts; thus, we investigated role HS extract in amelioration renovascular hypertension (RVH)-induced aortic remodeling. Materials methods: Thirty-five rats (7/group) were randomly...
2-Aroyl-4,5,6,7-tetrahalogeno-1,3-benzodioxoles (1) are readily obtained through the uncatalysed interaction between tetrahalogeno-o-benzoquinones and corresponding α-diazo-acetophenone or -acetonaphthone. They behave differently from all other methylenedioxy-compounds previously investigated with respect to cleavage by nucleophilic reagents. react phenylhydrazine in boiling n-butanol affording arylglyoxal bisphenylhydrazones (6) high yields. However, they resist benzoylhydrazine,...
F. G. Baddar, N. Latif and A. Nada, J. Chem. Soc., 1965, 7005 DOI: 10.1039/JR9650007005