Diabetes is the most common cause of end-stage renal disease, also called kidney failure. The link between artery receptor angiotensin II type I (AT1R) and endothelin-1 (ET-1), involved in vasoconstriction, oxidative stress, inflammation fibrosis (collagen) diabetes-induced nephropathy with without metformin incorporation has not been previously studied. (type 2) was induced rats another group started (200 mg/kg) treatment 2 weeks prior to induction diabetes continued on until being culled...

The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, fundamental unit cardiac muscle. Diabetes mellitus (DM) can cause to become dysregulated, following episodes nitrosative stress, through activation iNOS/mTOR/TIMP-1 pathway, thereby stimulating collagen deposition in myocardium. In this study, type 2 diabetes (T2DM) was induced rats. One group animals pre-treated with metformin (200 mg/kg) prior induction and subsequently kept on...

Autism spectrum disorder (ASD) is a collective neurodevelopmental affecting young children and accounting for 1% of the world’s population. The cerebellum major part human brain affected by ASD associated with substantial reduction in number Purkinje cells. An association between expression nitrosative stress biomarker inducible nitric oxide synthase (iNOS), as well glycogen deposition damaged cells, has not been previously reported medical literature. To explore this correlation, rats were...

Background: We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats it is associated with suppression of glycaemia, dyslipidemia inflammatory oxidative stress biomarkers.Materials methods: T2DM was induced by streptozotocin (50 mg/kg body weight) high carbohydrate fat diet (HCFD). The protective group put on (30 mg/kg) 14 days prior to induction continued HCFD until being sacrificed at...

The link between oxidative stress (ROS), apoptosis (p53) and fibrosis (collagen) in type 2 diabetes mellitus (T2DM)-induced cardiac injury the presence absence of antidiabetic drug, metformin has not been investigated before.T2DM was induced rats by a combination high carbohydrate fat diets (HCFD) streptozotocin (50 mg/kg) injection. protection group started (200 treatment 14 days prior to induction continued on HCFD until being sacrificed at week 12.Diabetes significantly blood levels ROS...

Breastfeeding provides unsurpassed natural nutrition to the newborn and infant. It has a nearly perfect mix of food elements vitamins that infants need grow up. Nonetheless, tendency for breastfeeding remains below expected levels.To explore attitudes barriers among mothers in Princess Nourah Abdulrahman University (PNU), Riyadh, Saudi Arabia.A cross-sectional study was conducted, from January April 2019; 399 PNU students, employees, faculty aged 18 years above with experience childbirth...

Diabetes is a known inducer of hepatic ultrastructural alterations, and the expression immune biomarker that involves in T-cell immunity, cluster differentiation 86 (CD86) increased diabetic patients with liver cirrhosis. The antidiabetic drug metformin has not previously been used to protect against type 2 diabetes mellitus (T2DM)-induced alternations ultrastructure induction CD86/inflammation axis animal models induced by streptozotocin high fat diet. To test our hypotheses, T2DM was rats...

Medical schools worldwide have employed different practices to facilitate a smooth transition from medical school into the internship phase promote success in graduates' future professional life. The College of Medicine at Princess Nourah University (PNU) has developed unique preparatory program focusing on soft and clinical skills.The aim this study was describe (IPP) evaluate its effectiveness improving students' internship.The IPP for fifth-year students PNU planned designed based needs,...

Osteoarthritis (OA) secondary to diabetes affects millions of people worldwide and can lead disability. The protective effect metformin pretreatment against alterations the articular cartilage ultrastructure induced by type 2 mellitus (T2DM) associated with inhibition oxidative stress inflammation has not been investigated before. Therefore, we T2DM in rats (the model group) using high carbohydrate fat diet a single injection streptozotocin (50 mg/kg body weight). group started (200 weight)...

MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA) and their syntheses are modulated by glycogen synthase kinase-3β (GSK-3β). Therefore, we hypothesised that GSK-3β inhibitor, TDZD-8 can protect against collagen-induced (CIA) via downregulating miR155 miR-24 expression. Rats were randomly allocated into four groups (n = 6) as follows: Control, Control + (1 mg/kg), CIA, CIA TDZD-8. sacrificed after 6 weeks. We observed model group significant (p<.05) increase...

The response of the immune system to harmful stimuli leads inflammation, and adverse effects toxic hepatitis chemical, thioacetamide (TAA) on human body are well documented. This article investigated degree protection provided by combined pleotropic drug, metformin (Met) plant polyphenolic antiinflammatory compound, resveratrol (Res) liver tissue exposed TAA possibly via inhibition inflammatory cytokine, tumor necrosis factor-α (TNF-α) / mammalian target rapamycin (mTOR) axis-mediated...

We sought to determine whether TDZD-8, the inhibitor of glycogen synthase kinase-3β (GSK3β), can protect synovial membrane knee joint against injuries induced by collagen type II immunization (CIA) possibly via downregulation leukocyte infiltration, endoplasmic reticulum stress (ERS), and autophagy. The model group rats were immunized over a period 3 weeks with II, whereas treated (CIA + TDZD-8) TDZD-8 (1 mg/kg) for 21 days after completion regimen. All then killed at week 6. Harvested...

Background In this study, we aimed to determine the prevalence of temporomandibular disorders (TMDs) and their association with psychological distress in central region Saudi Arabia. Methodology cross-sectional a questionnaire was sent randomly residents Al-Qassim province. They were asked complete TMD pain screener, Patient Health Questionnaire-4 (PHQ-4), Generalized Anxiety Disorder Scale (GAD-7). Correlations between symptoms pain-related TMDs PHQ-4 GAD-7 scores analyzed using Spearman's...

Diabetes represents a major public health problem and an estimated 70% of people with diabetes die cardiovascular complications. The protective effect insulin treatment against ultrastructural damage to the tunica intima media aorta induced by type 2 mellitus (T2DM) has not been investigated before using transmission electron microscopy (TEM). Therefore, we T2DM in rats high fat diet streptozotocin (50 mg/kg) administered daily i.v injection for 8 weeks group. Whereas, control group were...

Oxidative and inflammatory pathways play a significant role in the pathophysiology of wide variety non-communicable diseases such as type 2 diabetes mellitus (T2DM) hypertension. However, effect serum 25-hydroxyvitamin D ‎‎(25[OH]D) on these is still controversial. To evaluate association 25[OH]D ‎antioxidant pro-inflammatory biomarkers, reduced glutathione (GSH) tumor ‎necrosis factor (TNF)-α, T2DM hypertensive patients.This cross-sectional study consecutive sample patients attending Family...

Ingestion of an overdose paracetamol (also called acetaminophen, or APAP) induces hepatotoxicity that can lead to liver failure. The link between the pro-inflammatory microRNA-155 (miR-155) and leukocyte infiltration (CD45) in APAP- antioxidant depletion toxicity with without natural polyphenolic compounds, quercetin (QUR) plus resveratrol (RES) has not been previously studied. Therefore, acute hepatic injury was induced rats by 2 g/kg APAP (single dose, orally) another group started QUR (50...

Background and Objective: Inflammation fibrosis-induced swelling are key features in rheumatoid arthritis (RA) that causes joint damage disability.The inflammatory biomarker, Tumor Necrosis Factor-Alpha (TNF-") is known to be involved RA pathology.The can cause synovial membrane fibrosis through the activation of TNF-"/Vascular Endothelial Growth Factor (VEGF)/α-smooth muscle actin ("-SMA) pathway, which inhibited by TDZD-8, inhibitor enzyme Glycogen Synthase Kinase-3$ (GSK3$).Materials...

Rheumatoid arthritis (RA) that affects the synovial knee joint causes swelling of membrane and tissue damage. Interleukin-17A (IL-17A) enzyme glycogen synthase kinase-3β (GSK3β) are involved in pathogenesis RA. The link between IL-17A, GSK3β, oxidative stress, profibrogenic marker alpha-smooth muscle actin (α-SMA) with without TDZD-8, GSK3β inhibitor has not been studied before. Consequently, active immunization rats was performed to induce RA after three weeks using collagen type II...

Background: Burnout is a syndrome conceptualized as resulting from chronic workplace stress that has not been successfully managed. described in health-care workers and reported to be common primary health care physicians. This study aimed assess the prevalence rate of burnout, its associated factors, amongst doctors cluster one area, Riyadh, Saudi Arabia. Methods: cross-sectional design. The subjects consist general physicians, residents, registrars, senior consultants, nurses receptionist....