A5016527090- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Advances in Cucurbitaceae Research
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Trace Elements in Health
- Forensic Toxicology and Drug Analysis
- Cardiovascular Disease and Adiposity
- Heavy Metal Exposure and Toxicity
- Pancreatic function and diabetes
- Respiratory Support and Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Animal Diversity and Health Studies
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Liver Disease and Transplantation
- Vanadium and Halogenation Chemistry
- Heart Rate Variability and Autonomic Control
- Inflammatory mediators and NSAID effects
King Khalid University
2010-2024
Mansoura University
2019
Czech Academy of Sciences, Institute of Physiology
2016
University of Edinburgh
2006
Edinburgh Royal Infirmary
1998
Birmingham City University
1996
Problem statement: Cadmium is one of the most dangerous occupational and environmental toxins. It found in drinking water, atmospheric air even food. reported to be very toxic biological systems. Until now treating intoxication with this metal, chelating Compounds have been used, burdened numerous undesirable symptoms. For reason, many researches are carried out countries find natural-made compounds that help protection against cadmium induced toxicity fewer or no side effects. This study...
The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, fundamental unit cardiac muscle. Diabetes mellitus (DM) can cause to become dysregulated, following episodes nitrosative stress, through activation iNOS/mTOR/TIMP-1 pathway, thereby stimulating collagen deposition in myocardium. In this study, type 2 diabetes (T2DM) was induced rats. One group animals pre-treated with metformin (200 mg/kg) prior induction and subsequently kept on...
Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models. Glomerular ultrastructural alterations APAP overdose associated with the suppression biomarkers kidney injury have not been investigated before. Also, we whether combined polyphenolic antioxidants anti-inflammatory compounds, resveratrol (RES) quercetin (QUR) can protect against APAP-induced nephrotoxicity. Rats either received single (2...
The study was designed to evaluate the effect of Citrullus colocynthis pulp hydro-ethanol extract on alloxan-induced hyperlipidemia in diabetic rats. 24 albino rats with body weights 150 200 g were divided into one control and three experimental groups. Group 1 normal rats, orally administered physiological saline. Groups 2, 3 4 saline (diabetic, untreated), glibenclamide GL) or C. (300 mg /kg) CC), respectively. All treatments orally, a daily basis, for period 30 days. At end period,...
Abstract:Aim: To investigate the possible role of oxidative stress as a common mediator apoptosis and cardiac damage in diabetes. Materials Methods: This experimental work was conducted on 5 groups Wistar rats. Group I control group. Diabetes type 1 induced other (by streptozotocin) animals received insulin or vitamin E (300 mg /kg body weight), both E, no treatment for 4 weeks according to their At end study, serum tissues were examined biochemical parameters function, apoptosis. Electron...
Problem statement: Cadmium is a heavy metal of wide occupational and environmental contamination. In recent years, however, has been implicated in the pathogenesis several clinical disorders. One most frequently described problems aluminum toxicity anemia. Therefore, present study was carried out to determine effectiveness Camel's milk alleviating Aluminum Chloride (AlCl3) on certain hematological parameters antioxidant system components RBC's white albino rats. Approach: Albino rats both...
Objective: Diabetic complications such as cardiovascular disease and osteoarthritis (OA) are among the common public health problems. The effect of insulin on OA secondary to diabetes has not been investigated before in animal models. Therefore, we sought determine whether insulin-mimicking agent, vanadium can protect from developing diabetic rats. Methods: Type 1 mellitus (T1DM) was induced Sprague–Dawley rats treated with and/or vanadium. Tissues harvested articular cartilage knee joint...
Background Citrullus colocynthis pulp seedless extract has been demonstrated to have antihyperglycemic and insulinotropic effects. Problem statement: The mechanism(s) underlying the effects not investigated date. Approach: influence of administered orally was studied in alloxan diabetic white albino rats. Rats were divided into four groups, first group normal non rats given saline named control group, second treated-diabetic rats, third fourth treated with or glybenclamide (a positive...
Problem statement: The goal of the current investigation was to clarify effects Citrullus colocynthis pulp extract on structure liver diabetic rats at both light and scanning electron microscopic levels. Approach: Forty-eight adult male albino were equally allocated into four groups: Group1: control, Group 2: colocynthis-treated, 3: Group4: treated with colocynthis. All treatments administered via an intragastric tube. Diabetes induced in groups 3 4 by intraperitoneal injection alloxan....
We tested the hypothesis that swim exercise can protect articular cartilage from damages induced secondary to insulin-dependent diabetes mellitus in rats using scanning electron microscopy and monitor blood levels of oxidative antioxidative stress biomarkers are known be modulated osteoarthritis (OA). A profound damage was observed diabetic rats. Our findings also show protects knee joints by as well significantly inhibiting OA-induced upregulation thiobarbituric acid reactive substances...
This study investigated the protective effect of subacute pre-adminsitration either selenium (Se), taurine (Tau), or both drugs in combination against experimentally induced myocardial infarction (MI) rats and illustrates possible mechanisms action. While solely pre-administration Se Tau resulted partial amelioration all measured parameters MI rats, concomitant administration to significantly restored contractility function by increasing LVSP decreasing LVEDP normalized serum levels LDH,...
This study tested the protective effect of maslinic acid (MA) against diabetic retinopathy (DR) in rats with type 1 diabetes mellitus (T1DM) and investigated possible mechanisms action. DM was introduced by streptozotocin (STZ) (65 mg/kg, i.p.). Control STZ were divided into 2 subgroups, which received either vehicle or MA (80 mg/kg). Serum, pancreases, retinas collected for further use. significantly reduced fasting glucose levels control T1DM but enhanced insulin partially increased size...
Context: Crataegus aronia (syn. Azarolus L.) (Rosaceae) is used in traditional medicine due to its hypolipidaemic and antioxidant properties.Objectives: This study investigates the effect of C. whole plant aqueous extract on sperm parameter testicular structure control non-alcoholic fatty liver disease (NAFLD)-induced rats.Materials methods: Male rats were divided into six groups (10 each) as fed a standard diet (STD) (10% kcal), STD + (200 mg/kg), high-fat (HFD) (45% HFD aronia, followed by...
Diabetes is a known inducer of hepatic ultrastructural alterations, and the expression immune biomarker that involves in T-cell immunity, cluster differentiation 86 (CD86) increased diabetic patients with liver cirrhosis. The antidiabetic drug metformin has not previously been used to protect against type 2 diabetes mellitus (T2DM)-induced alternations ultrastructure induction CD86/inflammation axis animal models induced by streptozotocin high fat diet. To test our hypotheses, T2DM was rats...
Cardiovascular disease secondary to diabetes represents a significant challenge the health community. The advanced glycation end products (AGEs) play an important role in diabetes-mediated vascular injury. We tested whether metformin can suppress aortic AGEs production and protect against injuries (aortopathy) hypertension streptozotocin-induced type 2 mellitus (T2DM) animal model. T2DM was induced rats two weeks after being fed on high carbohydrate fat diet (HCFD), continued HCFD until...
Khat chewing is a recreational habit known to pose major socio-economic and medical problems in countries of Southern Arabia the Horn Africa. Among other adverse health effects, khat has been associated with an increased risk myocardial infarction (MI) heavy consumers. This study was carried out examine direct effects Catha edulis extract on contractility spontaneously contracting, isolated rabbit heart investigate its mechanism action. Isolated six rabbit’s hearts attached Langendorff...
This study investigated the effect of sub-chronic administration unacylated ghrelin (UAG) on steroidogenesis, sperm parameter, and reproductive function in lean high fat diet (HFD)-induced obese male rats. Rats were divided into 4 groups (n = 12 each) as 1) Control-fed standard diets (STD): (10 kcal%), 2) STD + UAG (200 ng/kg, i.p.), 3) HFD obese: fed (45 4) UAG. Diet regimen was continued for 16 weeks after which normal saline a vehicle or administered to desired next weeks. In vitro,...