West Nile virus (WNV) is transmitted via mosquito bites and causes ubiquitous zoonosis. Most infections in humans are asymptomatic, approximately 20% present as fever, less than 1% neuroinvasive disease. Central nervous system involvement presented meningitis, encephalitis, acute flaccid paralysis, or a combination of them. disease (WNND) has severe clinical course, potentially fatal outcome frequent neurological sequelae survivors. Risk factors for impairment advanced age immunosuppression....

Central nervous system infections continue to be a public health concern owing the high mortality and significant neurological sequelae among survivors. The diverse etiology with overlapping clinical laboratory abnormalities makes management of such patients challenging. Neuroinflammation plays an essential role in triggering oxidative stress autophagy dysregulation. Impaired may lead abnormal protein aggregation resulting neurodegeneration. YKL-40 is secreted glycoprotein, involved several...

Bacterial meningitis is a life-threatening disease with high mortality and common long-term sequelae. The inflammatory response in the subarachnoid space, modulated by different cytokines, plays major role pathogenesis of acute central nervous system infections. We aimed to examine correlations interleukin (IL)-6, IL-8, IL-10, IL-12(p40), tumor necrosis factor (TNF)-α levels severity, complications, outcome patients bacterial meningitis.The study involved 30 meningitis/meningoencephalitis...

Streptococcus equi subsp. zooepidemicus is a rare etiologic agent of bacterial meningitis in humans. The disease zoonotic infection and transmitted through close contact with domestic animals, mainly horses. Only 37 cases have been reported the literature until July 2023. aim this study to present clinical case S. zooepidemicus-related human immunodeficiency virus (HIV)-positive patient analyze literature. We 23-year-old horse breeder advanced immunosuppression due acquired syndrome (AIDS)...

COVID-19 presents with respiratory symptoms and signs in the majority of cases. The central nervous system can be affected directly or indirectly, which is demonstrated by a number neurological abnormalities complications. aim this study to present clinical case SARS-CoV-2-associated encephalitis highlight severity illness over course COVID-19. Etiological diagnosis methods include examination nasopharyngeal swab cerebrospinal fluid PCR.

Background. The world continues to struggle with the 2019 coronavirus disease (COVID-19). pandemic is under control, but exists and it extremely important have algorithms for early diagnostic prognostic guidance. aim of study find correlations between spectrum clinical symptoms severity outcome COVID-19, aiming maximally diagnosis establishing predictors fatal outcome. Materials methods. included 169 adults hospitalized at University Hospital St. George, Plovdiv, September 2021 December 2022...

Abstract Introduction. Bacterial meningitis is a severe disease with high mortality and frequent residual neurological sequelae. It associated multiple risk factors. The aim of the study was to establish main factors bacterial outline incidence chronic diseases in patients their relationship patients’ age etiology meningitis, if any. Materials methods. included 90 admitted Clinic Infectious Diseases, University Hospital “Sv. Georgi” – Plovdiv during period January 1, 2016 September 30, 2019....

Object: To analyze the clinical, epidemiological and laboratory characteristics of cases with measles in Plovdiv region, Bulgaria, period March-July 2017. Materials Methods: The study included 139 hospitalized patients measles, treated Clinic Infectious Diseases, University Hospital “St. George”—Plovdiv, during observed period. Diagnosis was verified by ELISA 133 patients. following methods were used: clinical analysis, laboratory, microbiological imaging tests. Results: age distribution...

Introduction: This case report describes a patient treated at the Clinic of Infectious Diseases University Hospital “St. George” Plovdiv, with two infections occurring same time – haemorrhagic fever renal syndrome (HFRS) and herpes simplex virus (HSV) encephalitis. Results: A 53-year-old male presented fever, flu-like impairment mild nitrogen elevation. The was Nephrology for one week. Several hours after discharge he had three generalised tonic-clonic seizures admitted to intensive care...

Abstract Introduction : Bacterial meningitis is an acute purulent infection of the meninges. There are significant differences in etiological spectrum, clinical course and outcome bacterial age groups, their recognition important for early diagnosis adequate therapy. Aim The study aims to determine etiology presentation between children adults. Materials methods included 90 patients (25 65 adults) with neuroinfection admitted St George University Hospital, Plovdiv January 1, 2016 September...