A5039280248- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Diverticular Disease and Complications
- Amoebic Infections and Treatments
- Anorectal Disease Treatments and Outcomes
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Actinomycetales infections and treatment
- Antibiotic Resistance in Bacteria
- Infectious Encephalopathies and Encephalitis
- Infectious Disease Case Reports and Treatments
- Thermal Regulation in Medicine
- Pharmacological Effects of Natural Compounds
- Mosquito-borne diseases and control
- Salmonella and Campylobacter epidemiology
- COVID-19 Clinical Research Studies
- Pediatric Pain Management Techniques
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Bartonella species infections research
- Parasites and Host Interactions
- Fungal Infections and Studies
Medical University Plovdiv
2019-2025
University Hospital Dr. Georgi Stranski
2023
St. George's University
2021
Despite being implicated in a wide spectrum of community- and healthcare-acquired infections, anaerobes have not yet been incorporated into systematic surveillance programs Europe. We conducted multicentre retrospective observational study analysing all anaerobic strains isolated from blood cultures 44 European Hospital Centres over 4-year period (2020-2023). Diagnostic approach, epidemiology, antimicrobial susceptibility according to EUCAST v. 15.0 were investigated. Our included 14,527...
: Anorectal abscesses are a relatively rare pathology in childhood. Most often, male children under 1 year of age affected. The importance microbiological examination for the diagnosis and treatment such patients remains debatable among surgeons, resulting scarce data being available literature. We aimed to identify aerobic spectrum antibiotic resistance isolates undergoing operation treat anorectal abscesses.
West Nile virus (WNV) is transmitted via mosquito bites and causes ubiquitous zoonosis. Most infections in humans are asymptomatic, approximately 20% present as fever, less than 1% neuroinvasive disease. Central nervous system involvement presented meningitis, encephalitis, acute flaccid paralysis, or a combination of them. disease (WNND) has severe clinical course, potentially fatal outcome frequent neurological sequelae survivors. Risk factors for impairment advanced age immunosuppression....
Ventilator-associated pneumonia (VAP) is the second most common hospital-acquired infection (HAI) among neonatal patients in intensive care units (ICUs) and a serious challenge for neonatologists because it affects critically ill who need prolonged mechanical ventilation. In Bulgaria, there no detailed data at regional national levels on characteristics of VAP newborns, which imposes necessity specific studies risk factors etiology VAP. The aim study was to analyze frequency, occurrence...
One of the most pressing public health problems is misuse antibiotics, especially in industrialized countries. In addition to antibiotic resistance, a disease associated with this abuse Clostridioides difficile infection (CDI). It also serious problem long-term hospital treatment, as it often causes intra-hospital infections. The coronavirus 2019 (COVID-19) pandemic has led widespread antibiotics and prolonged hospitalizations. aim our study was compare two groups patients who developed CDI...
Central nervous system infections continue to be a public health concern owing the high mortality and significant neurological sequelae among survivors. The diverse etiology with overlapping clinical laboratory abnormalities makes management of such patients challenging. Neuroinflammation plays an essential role in triggering oxidative stress autophagy dysregulation. Impaired may lead abnormal protein aggregation resulting neurodegeneration. YKL-40 is secreted glycoprotein, involved several...
Bacterial meningitis is a life-threatening disease with high mortality and common long-term sequelae. The inflammatory response in the subarachnoid space, modulated by different cytokines, plays major role pathogenesis of acute central nervous system infections. We aimed to examine correlations interleukin (IL)-6, IL-8, IL-10, IL-12(p40), tumor necrosis factor (TNF)-α levels severity, complications, outcome patients bacterial meningitis.The study involved 30 meningitis/meningoencephalitis...
Streptococcus equi subsp. zooepidemicus is a rare etiologic agent of bacterial meningitis in humans. The disease zoonotic infection and transmitted through close contact with domestic animals, mainly horses. Only 37 cases have been reported the literature until July 2023. aim this study to present clinical case S. zooepidemicus-related human immunodeficiency virus (HIV)-positive patient analyze literature. We 23-year-old horse breeder advanced immunosuppression due acquired syndrome (AIDS)...
The SARS-CoV-2 virus as well the COVID-19 mRNA vaccines cause an increased production of proinflammatory cytokines.We investigated relationship between ACE2, CTSL, AngII, TNFα and serum levels IL-6, IL-10, IL-33, IL-28A, CD40L, total IgM, IgG, IgA absolute count T- B-lymphocytes in patients, vaccinees healthy individuals.We measured humoral biomarkers (CD40L, IL-33) by ELISA method. Immunophenotyping lymphocyte subpopulations was performed flow cytometry. Total immunoglobulins were analyzed...
Background: Elizabethkingia spp. are Gram-negative, non-spore-forming bacteria that used to be rarely encountered but now they of growing clinical significance. Furthermore, the diagnostic challenges identification impede complete elucidation their epidemiology and association with human diseases. Case report: A 64-year-old man liver cirrhosis due alcohol abuse presented fatigue, abdominal swelling, bilateral scrotal edema. peritoneal fluid sample was cultured subject a number methods – API...
COVID-19 presents with respiratory symptoms and signs in the majority of cases. The central nervous system can be affected directly or indirectly, which is demonstrated by a number neurological abnormalities complications. aim this study to present clinical case SARS-CoV-2-associated encephalitis highlight severity illness over course COVID-19. Etiological diagnosis methods include examination nasopharyngeal swab cerebrospinal fluid PCR.
The genotyping of the multidrug-resistant Klebsiella pneumoniae species complex is essential to identify outbreaks and track their source spread. aim this study was improve extend typeability, availability, cost time efficiency an existing multi-locus VNTR analysis (MLVA). A modified scheme (MLVA8+) adopted validated for strain-level differentiation three involved in human pathology. diverse set 465 K. clinical isolates from 22 hospitals 3 outpatient laboratories Bulgaria were studied, where...
Improvement in medical care has turned severe diseases into chronic conditions, but often their treatment and use of devices are related to specific complications. Here we present a clinical case long-term dialysis patient, who is infected with rare opportunistic infectious agent – Gordonia sputi. In recent years the incidence spp. infections immunocompromised patients central venous catheters (CVC) appear rise. Their isolation identification challenging require modern techniques....
De la peau au cerveau: une suggestion pour diagnostiquer méningite à virus de l'herpès simplex type 2Introduction.Le 2 est reconnu comme l'une des causes les plus fréquentes aseptique.C'est aussi complication bien connue génital.Nous rapportons un cas récidivante sans séquelles génitales mais aux lésions cutanées simultanées qui ont constitué indice diagnostic.Présentation du cas.Un jeune homme a connu deux épisodes aseptique en 2019 et 2021, respectivement.Dans épisodes, manifestations...
Abstract Objective. To study both the molecular discrimination of D-tartrate fermenting and non-fermenting strains Salmonella enterica subsp. serotype Paratyphi B isolated from patients with paratyphoid fever clinical course this disease. Materials methods. The isolates examined were children aged 3 months to 9 years. A total 33 serotyped as B, an antigenic formula based on O- H- antigens: 1,4, [5], 12: b: 1,2 by Kauffmann–White classification. Results. Multiplex PCR analysis confirmed all...
Multimodal therapy, used for the treatment of patients with Hodgkin’s disease (HD), makes them prone to life-threatening infections, attributed mainly febrile neutropenia. Herein, we present a case report fatal combined bacterial and viral infection in 49-year-old female patient, subject polychemotherapy HD. Rapid microbiological diagnosis performed by multiplex polymerase chain reaction elucidated causes within hours. Listeria monocytogenes was detected both cerebrospinal fluid blood...
A supralevator anorectal abscess may lead to a rare clinical complication, such as perineal necrotizing fasciitis. 57-year-old man was admitted on an emergency basis with evidence of deep 5-day duration. The presentation involved unbounded purulent destructive inflammation spreading onto the adjacent areas, development septic condition. Following short preparation, radical surgical debridement subfascial necrotic phlegmon pelvic space performed. Since lower part abdomen, retroperitoneum and...
Abstract Introduction. Bacterial meningitis is a severe disease with high mortality and frequent residual neurological sequelae. It associated multiple risk factors. The aim of the study was to establish main factors bacterial outline incidence chronic diseases in patients their relationship patients’ age etiology meningitis, if any. Materials methods. included 90 admitted Clinic Infectious Diseases, University Hospital “Sv. Georgi” – Plovdiv during period January 1, 2016 September 30, 2019....
Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of devices are related to specific complications. Here, we present a clinical case long-term dialysis patient who was infected with rare opportunistic infectious agent-Gordonia sputi. In recent years, incidence Gordonia spp. infections immunocompromised patients central venous catheters (CVC) has appeared rise. The isolation identification challenging require modern...
Yersinia enterocolitica is a foodborne pathogen, mainly associated with disorders involving the gastrointestinal tract, including diarrhea, ileitis, and mesenteric lymphadenitis. Extraintestinal presentation uncommon in healthy individuals, but bacteremia reported immunocompromised hosts. We present 74-year-old male Y. serogroup O:3 who complicated to rupture of an abdominal aortic aneurysm. With current case report, we aimed emphasize association aneurysm rupture. Better surveillance...
INTRODUCTION: Systematic analyses and studies on the microbiological spectrum of anorectal abscesses (ARAs) are currently lacking in modern proctology. Microorganisms from colonic flora lead to retrograde infection glands with subsequent appearance ARA. AIM: The aim this article is analyze frequency, type, structure aerobic landscape adult patients operated for MATERIALS AND METHODS: A detailed analysis agents was performed 254 patients, a total 274 isolates, which were divided as follows:...
INTRODUCTION: Patients with anorectal abscesses (ARAs) represent the most common proctological emergency in area. Their wide distribution leads to clinical variety type and expression of inflammatory changes AIM: The aim this article is carry out a study different surgical methods order improve effectiveness operative treatment patients ARA. MATERIALS AND METHODS: A total 254 operated adult ARA were studied, whom 194 (76.4%) males 60 (23.6%) females. following used: incision, revision,...
BACKGROUND: Bacterial infections of the brain are associated with high mortality and neurological sequelae, whereas viral diseases usually self-limiting. A fast easy-to-perform biomarker is needed to improve management in these patients.
 AIM: Procalcitonin (PCT) testing has already been implemented many laboratories for evaluating septic patients it an easily accessible biomarker, so we aimed examine its role specifically discriminating acute bacterial from central nervous system...