A5041114560- Acute Lymphoblastic Leukemia research
- Infectious Disease Case Reports and Treatments
- Actinomycetales infections and treatment
- Infective Endocarditis Diagnosis and Management
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Health, Environment, Cognitive Aging
- Pharmaceutical studies and practices
- Epigenetics and DNA Methylation
Medical University Plovdiv
2022-2024
The prognosis for patients with relapsed childhood acute lymphoblastic leukaemia (cALL) remains poor. main reason treatment failure is drug resistance, most commonly to glucocorticoids (GCs). molecular differences between prednisolone-sensitive and -resistant lymphoblasts are not well-studied, thereby precluding the development of novel targeted therapies. Therefore, aim this work was elucidate at least some aspects matched pairs GC-sensitive cell lines. To address this, we carried out an...
Abstract Monitoring the blood serum activity of L-asparaginase in children with acute lymphoblastic leukaemia (ALL) has been highly recommended to detect enzyme inactivation that can cause relapse and avoid unwanted toxicity. Nevertheless, perhaps at least partially due lack clinically approved commercially available kits or standardized independently reproduced validated in-house protocols, laboratory assay-based determination optimal doses is not carried out routinely. In this study, we...
Improvement in medical care has turned severe diseases into chronic conditions, but often their treatment and use of devices are related to specific complications. Here we present a clinical case long-term dialysis patient, who is infected with rare opportunistic infectious agent – Gordonia sputi. In recent years the incidence spp. infections immunocompromised patients central venous catheters (CVC) appear rise. Their isolation identification challenging require modern techniques....
Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of devices are related to specific complications. Here, we present a clinical case long-term dialysis patient who was infected with rare opportunistic infectious agent-Gordonia sputi. In recent years, incidence Gordonia spp. infections immunocompromised patients central venous catheters (CVC) has appeared rise. The isolation identification challenging require modern...