A5012878891- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Retinal and Optic Conditions
- Global Health Care Issues
- Cytokine Signaling Pathways and Interactions
- Corneal surgery and disorders
- Health disparities and outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods in Clinical Trials
- Facial Rejuvenation and Surgery Techniques
- Infectious Diseases and Mycology
University of Illinois Chicago
2021-2024
Dana-Farber Cancer Institute
2017-2021
Visual Sciences (United States)
2021
Pfizer (United States)
2018
Dana-Farber Brigham Cancer Center
2018
Parker Institute for Cancer Immunotherapy
2018
Memorial Sloan Kettering Cancer Center
2018
Cornell University
2018
AstraZeneca (France)
2018
Foundation Medicine (United States)
2018
Purpose Although programmed death (PD)-1 pathway inhibitors are now used in nearly all patients with advanced non-small-cell lung cancer (NSCLC), the large number of NSCLC and concurrent autoimmune disease (AID) have been universally excluded from immunotherapy clinical trials. Therefore, safety PD-1 PD-ligand 1 (PD-L1) underlying AID is currently unknown. Methods As part a multi-institutional effort, we retrospectively collected clinicopathologic data history who received monotherapy either...
BackgroundIn non-small-cell lung cancers with programmed death-ligand 1 (PD-L1) expression on ≥50% of tumor cells, first-line treatment the PD-1 inhibitor pembrolizumab improves survival compared platinum-doublet chemotherapy. Whether higher PD-L1 levels within range 50%–100% predict for even greater benefit to is currently unknown.Patients and methodsIn this multicenter retrospective analysis, we analyzed impact overall response rate (ORR), median progression-free (mPFS), (mOS) in patients...
Programmed cell death protein 1 inhibitors increasingly are being used to treat patients with advanced lung carcinomas. death-ligand (PD-L1) immunohistochemistry (IHC) in tumor cells (TCs) and tumor-infiltrating immune (ICs) is select for programmed inhibition, but few studies have evaluated PD-L1 IHC cytology specimens. The objective of the current study was compare blocks matched surgical specimens.A total 56 specimens obtained between 2013 2016 matching were stained anti-PD-L1. Membranous...
Clinically-available biomarkers to identify the fraction of patients with small cell lung cancer (SCLC) who respond immune-checkpoint inhibitors (ICIs) are lacking. High nonsynonymous tumor mutational burden (TMB), as assessed by whole exome sequencing, correlates improved clinical outcomes for SCLC treated ICIs. Whether TMB targeted next generation sequencing (NGS) is associated efficacy ICIs in currently unknown. Here we determined whether NGS SCLC.We collected clinicopathologic data from...
To examine the association between neighborhood-level social vulnerability and adherence to scheduled ophthalmology appointments.
8511 Background: Dramatic responses to MET inhibitors have been reported in patients with NSCLC harboring activating mutations that cause exon 14 ( METdel14) skipping. We conducted a multicenter retrospective analysis of pts METdel14 determine if treatment impacts survival. Methods: collected clinicopathologic data on NSCLC. Event-time distributions were estimated using Kaplan-Meier and compared the log-rank test. Multivariable Cox models fitted estimate hazard ratios. Results: Of 148 mutant...
The purpose of this study was to evaluate Computer Vision Syndrome (CVS) in undergraduate and medical students since transitioning online learning during the COVID-19 pandemic.This a cross-sectional single center survey-based using validated CVS questionnaire (CVS-Q). survey distributed 20,080 680 at University Illinois Chicago. primary outcome measures were prevalence (based on severity score 6 or more), frequency intensity symptoms.The completed by 2300 (11.4% response rate) 154 (22.6%...
The application of artificial intelligence (AI) in diagnosing and managing ocular disease has gained popularity as research highlights the utilization AI to improve personalized medicine healthcare outcomes. objective this study is describe current optometric perspectives eye care.Members American Academy Optometry were sent an electronic invitation complete a 17-item survey. Survey items assessed perceived advantages concerns regarding using 5-point Likert scale ranging from "strongly...
Abstract Mohs micrographic surgery (MMS) is considered the gold standard for treating high-risk cutaneous basal cell carcinoma (BCC), but expensive, time-consuming, and can be unpredictable as to how many stages will required or large final lesion corresponding surgical defect be. This study meant investigate whether optical coherence tomography (OCT), a highly researched modality in dermatology, used preoperatively map out borders of BCC, resulting fewer MMS smaller defect. In this...
We pursued genomic analysis of an exceptional responder with non-small cell lung cancer (NSCLC) through a multi-platform effort to discover novel oncogenic targets.In this open-label, single-arm phase II study (NCT01829217), enriched cohort patients advanced NSCLC was treated the multi-kinase inhibitor sunitinib. The primary endpoint objective response rate. Tissue collected for responders, and candidate oncogene validated using in vitro models edited by CRISPR-Cas9.Of 13 enrolled, 1 patient...
Purpose Genomic profiling for personalized targeted therapy has become standard of care. We report the success genomic non–small cell lung cancer (NSCLC) obtained by trans‐thoracic needle biopsy (TTNB) in a single center experience. Materials and Methods Patients with NSCLC who underwent TTNB were identified. Pathology specimens evaluated tumor adequacy then analyzed selected exons epidermal growth factor receptor, KRAS, BRAF, PIK3CA, ERBB2. ALK rearrangements detected fluorescence situ...
9037 Background: Among patients with NSCLC and a PD-L1 TPS ≥50%, the response rate to PD-1 inhibitor pembrolizumab is ~45%. Whether certain subsets of ≥50% are more likely benefit from treatment currently unknown. We compared outcomes among treated first-line inhibitors different groupings: 50-74% vs 75-100%. Methods: retrospectively analyzed who received as for Dana-Farber Cancer Institute Memorial Sloan Kettering Center. Clinicopathologic characteristics clinical were Event-time...
Patient Adherence to Immunosuppressive Therapy for Chronic Inflammatory Eye Disease.
Purpose: To assess the predictability of phenylephrine testing for congenital ptosis and review outcomes Müller’s Muscle-conjunctival resection (MMCR) across ten years follow-up. Methods: In this retrospective case series, all patients who underwent MMCR at a single institution between 2010 2020 were identified. Exclusion criteria included had not undergone preoperative with 2.5% in superior fornix; revision surgery; broken suture early postoperative period. Demographics, margin-reflex...
Introduction This study evaluated the effect of a surgical opioid-avoidance protocol (SOAP) on postoperative pain scores. The primary goal was to demonstrate that SOAP as effective pre-existing non-SOAP (without opioid restriction) by measuring in diverse, opioid-naive patient population undergoing inpatient surgery across multiple services. Methods prospective cohort divided into and groups based date. group had no restrictions (n=382), while (n=449) used rigorous, order set with staff...
Background Magnetic Resonance Imaging (MRI) relies on optimal scanning parameters to achieve maximal signal-to-noise ratio (SNR) and high contrast-to-noise (CNR) between tissues resulting in quality images. The optimization of such is often laborious, time consuming, user-dependent, making harmonization imaging a difficult task. In this report, we aim develop validate computer simulation technique that can reliably provide “optimal vivo parameters” ready be used for evaluation disease...
PurposeThe purpose of the study is to investigate volumetric tumor burden dynamics and growth rates in ALK-rearranged advanced NSCLC patients during crizotinib monotherapy.MethodsThe included 44 treated with monotherapy as their initial ALK-directed therapy, who had at least one measurable lung lesion two follow-up CT scans, experienced volume increase while on crizotinib. The (in mm3) dominant was measured serial scans therapy for analysis after nadir.ResultsA total 231 measurements from...
Objective: Compare FDG-PET/CT, CT, and bone scan for detecting monitoring metastases’ response in metastatic renal cell cancer (mRCC). Methods: Patients with mRCC prospectively underwent scans at baseline after 8 weeks of therapy. Tumor visibility metabolic activity were retrospectively recorded. Response was evaluated by PERCIST, RECIST, MD Anderson criteria. Kaplan-Meier methodology estimated event-time distributions PFS, OS, time to symptomatic skeletal event (SSE). Log-rank test tested...
Background Previous studies found that infants with retinopathy of prematurity (ROP) who were treated for more posterior disease a greater number laser spots developed higher myopia. These included multiple physicians variations in density. In treatments by single physician, spot count is better surrogate area avascular retina and anterior-posterior location disease, so the relationship myopia can be assessed. Methods Our retrospective study ROP surgeon at center. Exclusion criteria...