A5103088812- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Ocular Oncology and Treatments
- Ophthalmology and Eye Disorders
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- IgG4-Related and Inflammatory Diseases
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Ocular Infections and Treatments
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Ocular Disorders and Treatments
- Ophthalmology and Visual Impairment Studies
- Proteoglycans and glycosaminoglycans research
- Traumatic Ocular and Foreign Body Injuries
- Neurofibromatosis and Schwannoma Cases
- Sarcoidosis and Beryllium Toxicity Research
- Retinal Imaging and Analysis
- Ocular and Laser Science Research
- Ophthalmology and Visual Health Research
King Khaled Eye Specialist Hospital
2015-2024
University of Illinois Chicago
2014-2024
Illinois College
1992-2024
Johns Hopkins Medicine
2013-2023
Johns Hopkins University
2014-2023
New York Eye and Ear Infirmary
2018-2023
University of Illinois Urbana-Champaign
1998-2023
Legacy Health
2023
Ophthalmology Associates (United States)
2002-2021
He Eye Hospital
2021
<h3>Objective</h3> To study expression and location of matrix metalloproteinases (MMPs) tumor necrosis factor α (TNF-α) in glaucomatous optic nerve heads, which are known to be secreted response a variety neuronal injury. <h3>Methods</h3> Four postmortem eyes from patients with primary open-angle glaucoma, 7 normal-pressure 4 age-matched normal donors were studied by immunohistochemistry. The sections the heads examined after immunostaining antibodies MMPs (MMP-1, MMP-2, MMP-3), TNF-α, or...
<h3>Background</h3> Serum autoantibodies that cross-react with glycosaminoglycans have been proposed to play a significant role in specific tissue injury patients systemic autoimmune diseases. <h3>Objective</h3> To investigate whether serum immunoreactivity is present glaucoma who aberrant DNA, RNA, nuclear proteins, or retinal as proteoglycans and their glycosaminoglycan side chains are important components of the optic nerve head its vasculature. <h3>Methods</h3> We performed Western...
Currently, there are numerous choices for the treatment of pediatric glaucoma depending on type glaucoma, age patient, and other particularities condition discussed in this review. Traditionally, goniotomy trabeculotomy ab externo have been preferred congenital a variety adult procedures adapted to children utilized types with variable results complications. More recently, seton implantations different become more popular use children, newer techniques available including visualized...
IgG4-related disease is an emerging clinical entity which frequently involves tissue within the orbit. In order to appreciate implications of IgG4 immunostaining, we analyzed gene expression and prevalence IgG4- immunostaining among subjects with orbital inflammatory diseases.We organized international consortium collect biopsies from 108 including 22 no known disease, 42 nonspecific (NSOI), 26 thyroid eye (TED), 12 sarcoidosis, 6 granulomatosis polyangiitis (GPA). Lacrimal gland adipose...
To evaluate changes in intraocular pressure (IOP), vision, and medications at least 1 year after phacoemulsification combined with endocyclophotocoagulation for advanced glaucoma cataract.A retrospective chart review was conducted on patients who underwent King Khaled Eye Specialist Hospital between 2005 2012. Data were collected patient demographics, type of glaucoma, IOP over time, best-corrected visual acuity, number medications, comorbidities, previous surgeries. Absolute success defined...
Sarcoidosis is a major cause of ocular or periocular inflammation. The pathogenesis sarcoidosis incompletely understood and diagnosis often requires biopsy.To determine how gene expression in either orbital adipose tissue the lacrimal gland affected by compares with other causes disease peripheral blood samples obtained from patients sarcoidosis.In multicenter, international, observational study, profiling formalin-fixed biopsy specimens, using GeneChipp U133 Plus 2 microarrays (Affymetrix),...
Ophthalmologists and optometrists have reported a higher prevalence of neck, hand/wrist lower back pain than family medicine physicians. Work-related musculoskeletal disorders not previously been studied in Saudi eye care professionals.To determine the magnitude determinants neck upper among professionals at tertiary hospital Arabia 2013.A cross-sectional study using close-ended questionnaire to frequency its association with age, sex, weight, comorbidities, duration professional work,...
<h3>Importance</h3> Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber eye. This most commonly known cause glaucoma and major irreversible blindness. <h3>Objective</h3> To determine if exfoliation associated with rare, protein-changing variants predicted to impair function. <h3>Design, Setting, Participants</h3> A 2-stage, case-control, whole-exome sequencing association...
To determine the toxicity of various doses intravitreal amphotericin B deoxycholate, lipid complex (ABLC), and liposomal (L-AmB).Fifty-two rabbits were divided into two treatment groups (groups A B). Thirteen treatments administered intravitreally to 104 rabbit eyes. Treatments included a control plus 10, 20, 30, 50 micro g ABLC, L-AmB. Eye examinations performed before injection on day 11 for group 18 B. At death, days 13 21 in B, respectively, vitreous humor was aspirated concentrations...
Neodymium:YAG cyclotherapy has been demonstrated to lower intraocular pressure dramatically in patients with uncontrolled glaucoma, potentially fewer side-effects than cyclocryotherapy. We report the clinical course and histopathological features of a case sympathetic ophthalmia occurring soon after YAG cyclotherapy.
<h3>Background/aims</h3> To clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed gene expression biopsies and compared our results with those reported for idiopathic pulmonary fibrosis. <h3>Methods</h3> We collected 140 from 138 patients (58 lacrimal glands; 82 fat). Diagnoses included healthy controls (n=27), non-specific inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) granulomatosis polyangiitis (GPA) (n=7). Fibrosis was scored...
Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients dacryoadenitis are diagnosed having nonspecific orbital inflammation (NSOI) on basis histology systemic disease evaluation. The ability to further classify in these should facilitate selection effective therapies.To test priori hypothesis that gene expression profiles would complement clinical histopathologic evaluations identifying diseases...
To evaluate the prevalence of glaucoma and its determinants among adult Saudi Residents aged 40 years older in Riyadh Governorate (except Capital).A cluster-based sample randomly selected citizens from six primary health center catchment areas were examined between 2014 2015. Data collected on their management. Assessment included measurement intraocular pressure, optic nerve head evaluation gonioscopy. Glaucoma suspects referred for visual field testing.A total 940 124 had glaucoma. The was...
This study aimed to evaluate attitudes, perceptions and perceived barriers towards health research among Saudi Arabian undergraduate medical students.This cross-sectional took place between August October 2014 included 520 students from five schools across Arabia. An anonymous online survey with 21 close-ended questions was designed assess students' attitudes research, contribution research-related activities, awareness of the importance perception available resources/opportunities for...