A5043986012- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- HER2/EGFR in Cancer Research
- Bladder and Urothelial Cancer Treatments
- Medical Imaging and Pathology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Urinary and Genital Oncology Studies
- Metastasis and carcinoma case studies
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- interferon and immune responses
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Renal cell carcinoma treatment
Dana-Farber Cancer Institute
2018-2023
Harvard University
2018-2022
National Cancer Research Institute
2022
Kindai University
2014-2019
National Center for Global Health and Medicine
2019
Aizawa Hospital
2015
Aichi Cancer Center
2007-2014
Hiroshima Prefectural Hospital
2011-2013
Okayama University
1996-2011
Mitsubishi Kyoto Hospital
2011
Most patients with non‐small cell lung cancer (NSCLC) harboring common epidermal growth factor receptor ( EGFR ) mutations, such as deletions in exon 19 or the L858R mutation 21, respond dramatically to tyrosine kinase inhibitors (EGFR‐TKI), and their sensitivities various EGFR‐TKI have been well characterized. Our previous article showed vitro of 18 mutations EGFR‐TKI, but little information regarding other uncommon is available. First, stable transfectant Ba/F3 lines (Ba/F3‐L858R), L861Q...
Abstract Lung cancers harboring common EGFR mutations respond to tyrosine kinase inhibitors (TKI). We previously reported that tumors with exon 18 are particularly sensitive irreversible second-generation (2G) afatinib compared first-generation TKIs (1G-TKI). However, data on the mechanisms of acquired resistance limited. established afatinib-resistant cells by transfecting Ba/F3 or (G719A and Del18) subjecting them chronic exposure increasing concentrations afatinib. Afatinib-resistant...
There is no consensus on the benefit of arthroscopically assisted reduction articular surface combined with fixation using a volar locking plate for treatment intra-articular distal radial fractures. In this study we compared functional and radiographic outcomes fluoroscopically guided these Between February 2009 May 2013, 74 patients unilateral unstable fractures were randomised equally into two groups treatment. The mean age was 64 years (24 to 92). We including active range movement...
Abstract Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Efforts to enhance the immunogenicity of cancer have been unsuccessful date. Here, we discover that MET amplification, most common mechanism resistance third-generation EGFR tyrosine kinase inhibitors (TKI), activates tumor cell STING, an emerging determinant (1). However, STING activation was restrained by ectonucleosidase CD73, which is induced MET-amplified, EGFR-TKI–resistant cells. Systematic...
Background: The pathogenesis of atopic dermatitis (AD) is still unknown. A recent study has shown that inducible nitric oxide synthase (iNOS) expressed in the skin lesion, suggesting involvement inflammation AD. purpose was to examine serum nitrate (NO 3 ) levels relation disease severity children with Methods: Serum were assessed scores 88 patients (aged 0.4–8 years: mean±SD, 2.2±1.9, 41 boys and 47 girls) 12 nonatopic 0.8–4 1.8±0.9, seven five girls). Results: AD significantly increased as...
The aim of this study is to elucidate the prognostic factors and treatment effect on survival in hepatocellular carcinoma (HCC) patients with Child C cirrhosis. Out 3330 newly discovered HCC patients, 157 consecutive individuals cirrhosis were enrolled. examined by Cox proportional hazards regression analysis their was compared propensity score-matched analysis. Multivariate revealed that high serum bilirubin (>3 mg dl−1), presence uncontrollable ascites, a platelet count (>8 × 104 mm−3),...
Abstract Background Assessment of hepatic functional reserve is important in resection. The aim this study was to evaluate the role asialoglycoprotein receptor (ASGP-R) analysis preoperative estimation remnant liver function surgery. Methods One hundred and one patients undergoing resection for tumours were studied. Seventeen had percutaneous transhepatic portal vein embolization (PTPE). Function estimated before surgery using radioactivity fusion images both single-photon emission computed...
This study aimed to identify the computed tomography characteristics of treatment-naïve patients with lung adenocarcinoma and known driver mutations in EGFR, KRAS, or ALK. Patients advanced (stage IIIB-IV) ALK were assessed. The radiological findings for main tumor intra-thoracic status retrospectively analyzed each group, groups' compared. We identified 265 non-small-cell carcinoma, who had EGFR (n = 159), KRAS 55), rearrangements 51). Among three groups, we evaluated only stage IIIB-IV...