A5101800812- Urinary Tract Infections Management
- Nephrotoxicity and Medicinal Plants
- Temporomandibular Joint Disorders
- Liver Disease Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Ion channel regulation and function
- dental development and anomalies
- Glycosylation and Glycoproteins Research
- Abdominal vascular conditions and treatments
- Autoimmune Bullous Skin Diseases
- Cancer-related gene regulation
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Infectious Aortic and Vascular Conditions
- Organ Transplantation Techniques and Outcomes
- Dermatology and Skin Diseases
- Liver Disease and Transplantation
- Aortic aneurysm repair treatments
- Microbial Natural Products and Biosynthesis
- Mechanics and Biomechanics Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroblastoma Research and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Venomous Animal Envenomation and Studies
Sendai Shakai Hoken Hospital
2020-2024
Tohoku University
1971-2023
Tohoku University Hospital
2022
Japan Community Healthcare Organization
2021
Health Promotion Board
2018
Keio University
2018
Tohoku Medical and Pharmaceutical University
2017-2018
Kurashiki Central Hospital
2017
Saga-Ken Medical Centre Koseikan
2015
University of Fukui
2015
1. Erabutoxin b was reduced, S-carboxymethylated and hydrolysed with trypsin. Seven tryptic fragments were isolated by column chromatography paper electrophoresis. Some of the further alpha-chymotrypsin, pepsin, Nagarse, Proctase A or B. The amino acid sequences fragment peptides determined subtractive Edman degradation. 2. From digest trifluoroacetylated erabutoxin two isolated. composition from terminal sequence studies on reduced b, above seven elucidated. 3. digestion a gave fragments,...
summary The aim of this study was to develop an objective evaluation system for the masticatory function. This used paraffin wax cubes as a test food, which had six red‐ and green‐coloured layers so that each surfaces showed pseudo‐checkered pattern. A total 100 were chewed by 37 subjects images these samples captured analysed using digital image analyzer. With regard colour shape sample, five parameters obtained. Furthermore, independent examiner graded degree mixing in into three groups...
Transforming growth factor-beta (TGF-beta) is secreted in a latent form and activated during co-culture of endothelial cells smooth muscle cells. Plasmin located on the surface required for activation TGF-beta (LTGF-beta) co-culture, targeting LTGF-beta to cellular requisite its activation. In present study, was examined. We detected specific binding 125I-large 1 isolated from human platelets but not A mAb against latency-associated peptide (LAP) large complex, which blocked cells, inhibited...
summary The objective of the study was to assess validity and reliability a newly developed method for evaluating mixing ability masticatory function. A two‐coloured paraffin wax cube used as test food in test. Eleven full dentate 33 denture wearers participated assessment. They were divided into three groups according their dental state. Validity assessed by Spearman's coefficient correlations between sieving ‘gold standard’ performance. subjects asked masticate foods 5, 7, 10, 15, 20 30...
We have isolated a full-length cDNA for human carbonic anhydrase IV (CA IV) from lambda gt10 kidney library. The 1105-base-pair (bp) contains 47-bp 5' untranslated region, 936-bp open reading frame, and 122-bp 3' region. deduced amino acid sequence is colinear with the N-terminal of several tryptic peptides lung CA IV. It includes an 18-amino signal sequence, 260-amino region that shows 30-36% similarity 29-kDa cytoplasmic CAs I, II, III), additional 27-amino C-terminal ends in 21-amino...
Abstract Background Impaired expression of E-cadherin and α- β-catenin is frequently observed in several human cancers. The aim this study was to examine immunohistochemical these adhesion molecules, focusing on early gastric carcinomas, investigate differences between differentiated undifferentiated cancer at the phase carcinogenesis. Methods Immunohistochemical staining performed using specimens from 143 patients with cancer. Results Abnormal correlated depth tumour invasion...
Abstract Background Assessment of hepatic functional reserve is important in resection. The aim this study was to evaluate the role asialoglycoprotein receptor (ASGP-R) analysis preoperative estimation remnant liver function surgery. Methods One hundred and one patients undergoing resection for tumours were studied. Seventeen had percutaneous transhepatic portal vein embolization (PTPE). Function estimated before surgery using radioactivity fusion images both single-photon emission computed...
Epidemiologic and pathologic studies were conducted between 1965 1986 to investigate trends for the incidence of coronary heart disease (CHD) its risk factors in urban rural populations relate factor changes CHD findings. The epidemiologic study included men aged 4059 years who residents Osaka. clerical manual workers Osaka, Akita prefecture. subjects autopsied 30 over, admitted a local hospital Akita, whose autopsy rate was 88%. From cohort 8, 835 employees 1975 1987, myocardial infarction...
PTEN, a gene encoding dual specificity phosphatase, is frequently altered in endometrial carcinoma. Moreover, these alterations are observed even atypical hyperplasia of the endometrium. This evidence suggests that mutation PTEN an early genetic alteration involved carcinogenesis. Adenovirus-mediated transfer was carried out using Ishikawa 3 H 12 and RL95-2, cancer cell lines with completely inactivated together HEC1-A KLE expressing wild-type as control. The transgene significantly...
Carbonic anhydrase II (CA II) deficiency has been shown to be the primary defect in recessively inherited syndrome of osteopetrosis with renal tubular acidosis. Until now, absence CA kidney II-deficient patients not directly, and status membrane-associated unclear. To address these questions, we analyzed urinary membranes soluble fractions from normal subjects. The activity membrane urine was found comprise two components--(i) a vesicle-enclosed, sodium dodecyl sulfate (SDS)-sensitive...
Phenotypic and chemotaxonomic characteristics of four isolates yeast-lysing bacteria isolated from wastewater treatment systems were examined. The nonsporeforming, gram-positive, facultative anaerobic, irregular rods that motile by multitrichous flagella. had an absolute requirement for hemin or hemoproteins aerobic growth. Under anaerobic conditions, the did not need heme compounds, but needed carbon dioxide. deoxyribonucleic acid (DNA) base composition was 65.7 to 66.1 mol% guanine plus...
The ontogeny of inhibin secretion in the testis rats was investigated. Testicular localization, content immunoactive and bioactive its molecular size fetal neonatal (from 16 days gestation to 5 age) were determined. Strong immunostaining with an antiserum against a polypeptide porcine alpha-subunit noted testicular interstitial cells from gestation. Co-localization 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) observed until 2 age. Immunoreactive tissue had disappeared by age, although...
MUC1 mucin is known to be highly expressed in carcinomas that show invasive growth and poor prognosis. Impairment of adhesion molecule E-cadherin expression has been widely accepted as a critical event for cancer invasion metastasis. The present study evaluated the combination status possible predictor patients suitable minimally therapy gastric cancer.Two hundred nine paraffin-embedded specimens carcinoma (141 early, 68 advanced) were examined by immunohistochemical staining using...
summary The aim of this study was to clarify the influence working side contacts for masticatory function a distal extension removable partial denture. Five subjects who had edentulous arches from second premolar molar opposing natural teeth participated. Working were altered by using three types artificial attached denture base. A‐form made contact with opposite while acting as in lateral excursion. cusp angles B‐ and C‐form decreased 10° 20°, respectively compared teeth. B‐and discluded on...
The microstructure of biomaterials influences the cellular and biological responses in bone. Octacalcium phosphate (OCP) exhibits higher biodegradability osteoconductivity than hydroxyapatite (HA) during conversion process from OCP to HA. However, effect crystals on long tubular bones has not been clarified. In this study, two types OCPs with different microstructures, fine-OCP (F-OCP) coarse-OCP (C-OCP), were implanted rat tibia for 4 weeks. F-OCP promoted cortical bone regeneration...
<i>Background:</i> The efficacy of direct hemoperfusion with polymyxin B-immobilized fiber columns (PMX) has already been demonstrated in clinical studies for the treatment septic shock. However, serum procalcitonin levels following PMX remain unknown. <i>Methods:</i> This prospective, multicenter, nonrandomized study was performed at 12 institutions. Forty-five patients severe sepsis or shock due to colorectal perforation underwent PMX. Patients’ outcome as well...