A5110781512- Lymphoma Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Lung Cancer Treatments and Mutations
- Infectious Diseases and Mycology
- Ectopic Pregnancy Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cancer Risks and Factors
- Lymphatic Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Classical Philosophy and Thought
- Pituitary Gland Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Lipids, and Metabolism
- Vascular Malformations and Hemangiomas
- Cardiac Valve Diseases and Treatments
- Religious, Philosophical, and Educational Studies
- Aortic aneurysm repair treatments
- Alcohol Consumption and Health Effects
- Syphilis Diagnosis and Treatment
- CAR-T cell therapy research
- Myasthenia Gravis and Thymoma
- Inflammatory Biomarkers in Disease Prognosis
- Aortic Disease and Treatment Approaches
Hospitais da Universidade de Coimbra
2019-2024
University of Coimbra
2021-2022
Interim response evaluation by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (iPET) in diffuse large B cell lymphoma (DLBCL) could be important to rule out disease progression and has been suggested predictive of survival. However, treatment guidance iPET is not yet recommended for DLBCL clinical practice. We aimed compare the value when utilizing visual Deauville 5-point scale (DS) semiquantitative variation maximum standardized uptake (ΔSUVmax).We included 85...
Twin-to-twin transfusion syndrome (TTTS) is a serious complication typical of monochorionic pregnancies. Cases in dichorionic pregnancies have been described. The authors present case report presumed TTTS pregnancy followed at our institution which the patient presented to emergency department 31 4/7 weeks’ gestation complaining lack fetal movements. Both fetuses did not show any cardiac activity. On first twin, an oligohydramnios was and his bladder visualised and, on second polyhydramnios...
Pulmonary arteriovenous malformations (AVMs) are abnormal connections between the pulmonary arteries and veins that can result in rapid-onset heart failure. We present a case of fetus with AVMs diagnosed at 22 weeks gestation. Fetal echocardiography showed cardiomegaly dilated reflecting hemodynamic significance shunt. Inverted flow through ductus arteriosus was also present. autopsy following medical termination pregnancy confirmed morphological findings, including displacement proximity to...
Introduction: Interim response evaluation by PET (iPET) in diffuse large B cell lymphoma (DLBCL) is encouraged to rule out disease progression and has been suggested be predictive of survival. However, treatment guidance iPET not yet recommended for DLBCL clinical practice. We aimed assess the value free survival (PFS) overall (OS) patients (pts). Methods: Single centre retrospective analysis pts diagnosed with from 2010 2019, uniformly treated R-CHOP/R-CHOP-like protocols (6-8 cycles)...
Introduction: Bone marrow assessment (BMI) is an important part of disease staging in lymphoma, and includes FDG18-PET BM trephine biopsy (BMB), which the gold-standard for detecting infiltration. Nevertheless, studies indicate that PET accurately detects BMI aggressive lymphomas. We aimed to assess accuracy diffuse large B-cell lymphoma (DLBCL). Methods: Single centre retrospective analysis 335 patients (pts) diagnosed with DLBCL from 2010 2019. BMB data at diagnosis was available 144 pts....
Abstract CHD may, at times, occur in the framework of other rare pathologies. These, having similar clinical manifestations, present a diagnostic dilemma for clinician. The authors case an infant with non-syndromic complete atrioventricular septal defect, whose post-operative period was surprisingly complicated by progressive pulmonary hypertension. Despite intensive care, ultimately died. diagnosis unilateral primary lymphangiectasia only possible post mortem .
Drug-induced liver injury is hardly diagnosed, considering not only the wide range of hepatotoxic substances but also diversity associated phenotypes and absence specific biomarkers. Symptom chronology, drug or toxic exposure, temporal association help to establish diagnosis. Exposure isopropanol has known rare effects. We report clinical case a 33-year-old female hairdresser admitted hospital with fatigue, epigastric pain, jaundice. She presented following values: aspartate...
Sarcomas are rare and characterised by an incidence of approximately 5 cases/100.000 people. Primary spindle cell sarcomas a subclassification soft tissue sarcomas, known as uncertain differentiation tumours, based on their unspecific line differentiation. It might begin in layers connective under the skin, between muscles or surrounding organs. Diagnosis can be challenging delayed due to often-painless nature these cancers common assumption underlying benign condition. The presence distant...
Introduction: The prognostic impact of body mass index (BMI) in diffuse large B cell Lymphoma (DLBCL) patients is controversial, as some studies showed a survival benefit for higher BMI while others no correlation or even detrimental effect on survival. On the other hand, regarding nutritional status outcome have shown that lower Prognostic Nutritional Index (PNI) scores are related to Progression Free Survival (PFS) and Overall (OS). Aim: Evaluate PNI at diagnosis OS PFS cohort with DLBCL,...
Introduction: Diffuse Large B Cell Lymphoma (DLBCL), the most common non-Hodgkin lymphoma, despite having a standard of care treatment (R-CHOP), has heterogeneous clinical and molecular features. The widely used risk scores are based on biochemical parameters, which can underestimate impact genomic signatures. Recognizing score with better discriminative power might be important to identify high-risk group, for whom R-CHOP may insufficient. We aim compare prognostic efficacy in DLBCL: IPI...
Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and more frequent in elderly patients (pts), which have a worse prognosis than younger patients. This partially explained by existence comorbidities poor performance functional status, limiting use R-CHOP as standard therapy. We aim to evaluate impact clinical factors therapeutic decisions outcomes DLBCL pts. Methods: Retrospective analysis >65 years pts with DLBCL, NOS diagnosed our center,...
Background: During the past few years, several studies have tried to identify biomarkers that could improve current prognostic assessment in diffuse large B-cell lymphoma (DLBCL). Neutrophil/Lymphocyte Ratio (NLR) and Monocyte/ Lymphocyte (MLR) are simple, cost-effective readily available tools may a significance DLBCL treated with R-CHOP, according some studies. Aims: To determine value of NLR MLR DLBCL, Not Otherwise Specified (NOS). Methods: Retrospective analysis 335 patients (pts) newly...
Abstract Background Twin-to-twin Transfusion Syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. Affects about 10% to 15% pregnancies and it associated with high fetal neonatal mortality, as well cardiac neurological morbidity in surviving fetuses. The main objective was characterize series fetuses TTTS since the pathophysiology syndrome not fully understood clinical spectrum broad. Methods Post-mortem macroscopic microscopic examination 26 (from 2010 2020) syndrome....
Abstract Background Foetal Hydrops (FH) is an abnormal accumulation of fluid inside two or more serous cavities and may be linked with polyhydramnios and/or placental oedema. It has been correlated several causes such foetal anaemia, chromosomal anomalies, congenital abnormalities, infections, twin-to-twin transfusion syndrome maternal as diabetes. Regardless the advances in diagnosis therapy, overall perinatal mortality rate remains high. Thereby, main goal to evaluate autopsy findings...