Manish Kuchakulla

ORCID: 0000-0003-2238-6752
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About
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Research Areas
  • Hormonal and reproductive studies
  • Prostate Cancer Treatment and Research
  • Sperm and Testicular Function
  • Cancer, Stress, Anesthesia, and Immune Response
  • Ovarian function and disorders
  • Reproductive Biology and Fertility
  • COVID-19 Impact on Reproduction
  • Nitric Oxide and Endothelin Effects
  • Glioma Diagnosis and Treatment
  • Prostate Cancer Diagnosis and Treatment
  • Nutritional Studies and Diet
  • Reproductive Health and Technologies
  • Sexual function and dysfunction studies
  • Agriculture Sustainability and Environmental Impact
  • Brain Metastases and Treatment
  • Immune cells in cancer
  • Healthcare cost, quality, practices
  • Consumer Attitudes and Food Labeling
  • Chemokine receptors and signaling
  • Cancer Immunotherapy and Biomarkers
  • Sexuality, Behavior, and Technology
  • Cancer, Hypoxia, and Metabolism
  • Stress Responses and Cortisol
  • Sex and Gender in Healthcare
  • Pharmacology and Obesity Treatment

Cornell University
2022-2025

New York Hospital Queens
2025

Weill Cornell Medicine
2024

University of Miami
2017-2023

Florida International University
2022-2023

Emory University
2023

University of Tennessee Health Science Center
2023

University of California, Berkeley
2023

Yale University
2023

Case Western Reserve University
2023

The Emergency Use Authorization (EUA) of the COVID-19 vaccine on December 11, 2020 has been met with hesitancy for uptake some citing potential impacts future fertility. We hypothesised that irrespective sex, fertility-related queries would markedly increase during 48 days following EUA coronavirus vaccine. sought to objectively identify trends in internet search public concerns regarding side effects fertility might impact uptake. used Google Trends investigate Google's Search Engine...

10.1111/and.14156 article EN Andrologia 2021-06-28

PURPOSE: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created a surge of research to help better understand the breadth possible sequelae. However, little is known regarding impact on semen parameters and fertility potential. We sought investigate for presence viral RNA in men with SARS-CoV-2 infection evaluate its effect ejaculate. MATERIALS AND METHODS: prospectively recruited thirty diagnosed using real-time reverse transcriptase polymerase chain reaction...

10.5534/wjmh.200192 article EN cc-by-nc The World Journal of Men s Health 2021-01-01

Significance This study presents insights into the underexplored areas of castration-resistant prostate cancer (CRPC) therapeutics—the role nitric oxide (NO) in CRPC reduction through its microenvironment. Results this provide important information on tumor capabilities increased NO levels and mechanistic aspect demonstrates potential long-term efficacy CRPC. An in-depth understanding how affects microenvironment will allow development chemotherapeutics based for a cure.

10.1073/pnas.1812704115 article EN Proceedings of the National Academy of Sciences 2018-10-15

Sustained oxidative stress in castration-resistant prostate cancer (CRPC) cells potentiates the overall tumor microenvironment (TME). Targeting TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for CRPC. However, therapeutic response to sustained CSF1R (CSF1Ri) limited as monotherapy. We hypothesized that one of underlying causes reduced efficacy CSF1Ri and increased oxidation CRPC upregulation uncoupling endothelial nitric oxide synthase (NOS3). Here...

10.1038/s41419-022-05289-4 article EN cc-by Cell Death and Disease 2022-10-08

Relationships between various ethnicities and glioma subtype have recently been established. As a tertiary referral center for Latin America the Caribbean, our institution treats diverse glioblastoma (GBM) population. We sought to clarify role of ethnicity on patient prognosis in GBM also compared these findings group consisting elderly patients. included 'elderly' as because subgroups within them were too small. It allowed us put scope effects overall survival. Material Methods: After...

10.7759/cureus.954 article EN Cureus 2017-01-04
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