A5074168624- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Meningioma and schwannoma management
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Vestibular and auditory disorders
- Neurofibromatosis and Schwannoma Cases
- Ear and Head Tumors
- Cancer, Stress, Anesthesia, and Immune Response
- Salivary Gland Tumors Diagnosis and Treatment
- Ovarian function and disorders
- CNS Lymphoma Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Trigeminal Neuralgia and Treatments
- Hearing Loss and Rehabilitation
- Protease and Inhibitor Mechanisms
- Palliative Care and End-of-Life Issues
- Cancer, Hypoxia, and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Ultrasound Imaging and Elastography
- Immune cells in cancer
- Thyroid and Parathyroid Surgery
- Respiratory and Cough-Related Research
- Health Literacy and Information Accessibility
- Clinical practice guidelines implementation
University of Pennsylvania
2022-2025
University of Pennsylvania Health System
2024
Cochlear (Australia)
2021
Hospital of the University of Pennsylvania
2021
University of Miami
2018-2020
Unilateral sphenoid sinus opacification on computed tomography is caused by a variety of pathologies including inflammatory and infectious sinusitis, benign malignant tumors, encephaloceles. The purpose this study was to report craniofacial pain locations outcomes in unilateral sinusitis (USS) patients who underwent endoscopic surgery (ESS).
Sinonasal inverted papilloma (IP) is the most common benign tumor found in nasal cavity and has potential for locally destructive effects malignant transformation [1-3]. Birkenbeuel et al. demonstrate that 565 patients with squamous cell carcinoma of their IP, 5-year overall survival rate was 62% a mean recurrence time 24.3 months [4]. Therefore, follow-up crucial detection preemptive revision resection prior to transformation. While postulated, it not yet been examined how socioeconomic...
Significance This study presents insights into the underexplored areas of castration-resistant prostate cancer (CRPC) therapeutics—the role nitric oxide (NO) in CRPC reduction through its microenvironment. Results this provide important information on tumor capabilities increased NO levels and mechanistic aspect demonstrates potential long-term efficacy CRPC. An in-depth understanding how affects microenvironment will allow development chemotherapeutics based for a cure.
Abstract Objective We aim to evaluate the role of elective neck dissection (END) and adjuvant radiation on survival in N0 high‐grade mucoepidermoid carcinoma (MEC). Study Design Retrospective cohort study. Setting National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) database. Methods All patients diagnosed with MEC node‐negative disease (N0) from 2004 2018 were included. Demographic, clinicopathologic, treatment, outcomes analyzed. Kaplan‐Meier curves used 5‐year...
Sinonasal malignancies are a unique subset of head and neck cancers that necessitate close monitoring due to high local recurrence rates. Surveillance consists combination endoscopy, imaging, patient-reported symptomatology, but no standardized surveillance protocols currently exist. Strategies historically have been based on guidelines for other malignancies; however, the anatomical histologic presentation sinonasal presents challenges. This review discusses literature surrounding utility...
Background To reduce recurrence rates of inverted papilloma (IP), some have argued for the use intraoperative frozen margins; results remain mixed and studies critically lack lengthy surveillance periods. Objective We aim to elucidate impact prolonged margins on IP recurrence. Methods This is a retrospective analysis patients who underwent resection at tertiary care center over 10-year period from 2008 2018 followed by subsequent surveillance. Patient demographics, tumor operative...
Management of the neck in laryngeal squamous cell carcinoma (LSCC) is essential to oncologic control and survival. We aim describe patterns rates clinical/pathologic lymph node disease, elective dissection (END), occult metastasis (LNM) patients with surgically-managed LSCC.Retrospective cohort study National Cancer Database (NCDB) diagnosed LSCC between January 2004 December 2016 who underwent primary surgery.Seven thousand eight hundred seventy-six met inclusion criteria. For cN0 patients,...
Odontogenic cysts impact the adjacent dentition and maxillary sinus. A combined transnasal, transoral approach for removal offers reduced recurrence rates favorable sinonasal outcomes compared with historic transoral-only approaches. are fluid-filled, epithelial-lined cavities of dental origin potential to damage sinus associated symptomatology.1 These can be developmental or inflammatory include diverse pathologies such as odontogenic keratocysts (OKCs), dentigerous cysts, radicular among...
<b><i>Introduction:</i></b> Chronic rhinosinusitis (CRS) can be associated with tumors involving the maxillary sinus, but outcomes after undergoing maxillectomy free flap reconstruction remain unclear. <b><i>Methods:</i></b> A retrospective analysis of medical records was performed to evaluate evidence CRS in patients who underwent at a single tertiary care academic institution from 2013 through 2020....
Inverted papilloma (IP) is a benign tumor characterized by epithelial proliferation, which has the potential for malignant transformation. However, mechanisms driving this transformation are poorly defined. Matrix metalloproteinase-11 (MMP-11), regulator of microenvironment that degrades extracellular matrix, upregulated in IP with dysplasia. Here, we aim to investigate role MMP-11 migration and invasion.
Major salivary gland cancers (MSGCs) are often treated with primary surgery followed by adjuvant therapy for high-risk pathology. Patients these may opt out of recommended postoperative radiation (PORT) many reasons and consequently suffer worse outcomes.Retrospective cohort study.National Cancer Database.Patients diagnosed MSGC from 2004 to 2016 were identified, overall survival risk factors refusal PORT analyzed based on demographic, socioeconomic, clinical factors. Multivariable logistic...
Abstract Objective To characterize adverse events, provide a safety profile, and understand patient outcomes after complications arising from LigaSure Harmonic use in the head neck region. Methods Retrospective analysis of events Manufacturer User Facility Device Experience (MAUDE) between January 2013 2023. Results A total 158 159 were extracted. There significantly more reports device overheating (6.9% vs. 0.6%, p = 0.003) spontaneous self‐activation (4.4% 0%, 0.032). Although...
Patients are increasingly turning to online education materials aid with disease management. Patient on aspirin-exacerbated respiratory of poor readability significant room for improvement.
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (MP81)1 Apr 2019MP81-04 ALTERATIONS OF TUMOR MICROENVIRONMENT BY NITRIC OXIDE DONOR IMPEDES CASTRATION RESISTANT PROSTATE CANCER GROWTH Himanshu Arora*, Kush Panara, Manish Kuchakulla, Shathiyah Kulandavelu, Kerry L. Burnstein, Andrew V. Schally, Joshua M. Hare, and Ranjith Ramasamy Arora*Himanshu Arora* More articles by this author , PanaraKush Panara KuchakullaManish Kuchakulla KulandaveluShathiyah...